KEGG   Homo sapiens (human): 1457
Entry
1457              CDS       T01001                                 
Symbol
CSNK2A1, CK2A1, CKII, Cka1, Cka2, OCNDS
Name
(RefSeq) casein kinase 2 alpha 1
  KO
K03097  casein kinase II subunit alpha [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03008  Ribosome biogenesis in eukaryotes
hsa04064  NF-kappa B signaling pathway
hsa04137  Mitophagy - animal
hsa04310  Wnt signaling pathway
hsa04520  Adherens junction
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05162  Measles
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06512  Chromosome cohesion and segregation
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01202  Oligomeric conformation PrPc to anterograde axonal transport
N01501  Inactivation of condensin I
N01620  Blocking ubiquitination of H2AK119 by CK2
Disease
H02854  Okur-Chung neurodevelopmental syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    1457 (CSNK2A1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    1457 (CSNK2A1)
   04064 NF-kappa B signaling pathway
    1457 (CSNK2A1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    1457 (CSNK2A1)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    1457 (CSNK2A1)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    1457 (CSNK2A1)
  09172 Infectious disease: viral
   05162 Measles
    1457 (CSNK2A1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1457 (CSNK2A1)
   05020 Prion disease
    1457 (CSNK2A1)
   05022 Pathways of neurodegeneration - multiple diseases
    1457 (CSNK2A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1457 (CSNK2A1)
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis [BR:hsa03009]
    1457 (CSNK2A1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     1457 (CSNK2A1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  CK2 family
   1457 (CSNK2A1)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  90S particles
   Kinase
    1457 (CSNK2A1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH ABC1 Kdo Pkinase_fungal Choline_kinase MFS18 DUF5898 FTA2
Other DBs
NCBI-GeneID: 1457
NCBI-ProteinID: NP_001349699
OMIM: 115440
HGNC: 2457
Ensembl: ENSG00000101266
UniProt: P68400
Structure
LinkDB
Position
20:complement(472498..543790)
AA seq 391 aa
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
NT seq 1176 nt   +upstreamnt  +downstreamnt
atgtcgggacccgtgccaagcagggccagagtttacacagatgttaatacacacagacct
cgagaatactgggattacgagtcacatgtggtggaatggggaaatcaagatgactaccag
ctggttcgaaaattaggccgaggtaaatacagtgaagtatttgaagccatcaacatcaca
aataatgaaaaagttgttgttaaaattctcaagccagtaaaaaagaagaaaattaagcgt
gaaataaagattttggagaatttgagaggaggtcccaacatcatcacactggcagacatt
gtaaaagaccctgtgtcacgaacccccgccttggtttttgaacacgtaaacaacacagac
ttcaagcaattgtaccagacgttaacagactatgatattcgattttacatgtatgagatt
ctgaaggccctggattattgtcacagcatgggaattatgcacagagatgtcaagccccat
aatgtcatgattgatcatgagcacagaaagctacgactaatagactggggtttggctgag
ttttatcatcctggccaagaatataatgtccgagttgcttcccgatacttcaaaggtcct
gagctacttgtagactatcagatgtacgattatagtttggatatgtggagtttgggttgt
atgctggcaagtatgatctttcggaaggagccatttttccatggacatgacaattatgat
cagttggtgaggatagccaaggttctggggacagaagatttatatgactatattgacaaa
tacaacattgaattagatccacgtttcaatgatatcttgggcagacactctcgaaagcga
tgggaacgctttgtccacagtgaaaatcagcaccttgtcagccctgaggccttggatttc
ctggacaaactgctgcgatatgaccaccagtcacggcttactgcaagagaggcaatggag
cacccctatttctacactgttgtgaaggaccaggctcgaatgggttcatctagcatgcca
gggggcagtacgcccgtcagcagcgccaatatgatgtcagggatttcttcagtgccaacc
ccttcaccccttggacctctggcaggctcaccagtgattgctgctgccaacccccttggg
atgcctgttccagctgccgctggcgctcagcagtaa

KEGG   Homo sapiens (human): 1459
Entry
1459              CDS       T01001                                 
Symbol
CSNK2A2, CK2A2, CK2alpha', CSNK2A1
Name
(RefSeq) casein kinase 2 alpha 2
  KO
K03097  casein kinase II subunit alpha [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03008  Ribosome biogenesis in eukaryotes
hsa04064  NF-kappa B signaling pathway
hsa04137  Mitophagy - animal
hsa04310  Wnt signaling pathway
hsa04520  Adherens junction
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05162  Measles
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06512  Chromosome cohesion and segregation
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01202  Oligomeric conformation PrPc to anterograde axonal transport
N01501  Inactivation of condensin I
N01620  Blocking ubiquitination of H2AK119 by CK2
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    1459 (CSNK2A2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    1459 (CSNK2A2)
   04064 NF-kappa B signaling pathway
    1459 (CSNK2A2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    1459 (CSNK2A2)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    1459 (CSNK2A2)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    1459 (CSNK2A2)
  09172 Infectious disease: viral
   05162 Measles
    1459 (CSNK2A2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1459 (CSNK2A2)
   05020 Prion disease
    1459 (CSNK2A2)
   05022 Pathways of neurodegeneration - multiple diseases
    1459 (CSNK2A2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1459 (CSNK2A2)
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis [BR:hsa03009]
    1459 (CSNK2A2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     1459 (CSNK2A2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  CK2 family
   1459 (CSNK2A2)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  90S particles
   Kinase
    1459 (CSNK2A2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH ABC1 Pkinase_fungal Choline_kinase DUF5898 Kdo
Other DBs
NCBI-GeneID: 1459
NCBI-ProteinID: NP_001887
OMIM: 115442
HGNC: 2459
Ensembl: ENSG00000070770
UniProt: P19784
Structure
LinkDB
Position
16:complement(58157907..58198106)
AA seq 350 aa
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgcccggcccggccgcgggcagcagggcccgggtctacgccgaggtgaacagtctgagg
agccgcgagtactgggactacgaggctcacgtcccgagctggggtaatcaagatgattac
caactggttcgaaaacttggtcggggaaaatatagtgaagtatttgaggccattaatatc
accaacaatgagagagtggttgtaaaaatcctgaagccagtgaagaaaaagaagataaaa
cgagaggttaagattctggagaaccttcgtggtggaacaaatatcattaagctgattgac
actgtaaaggaccccgtgtcaaagacaccagctttggtatttgaatatatcaataataca
gattttaagcaactctaccagatcctgacagactttgatatccggttttatatgtatgaa
ctacttaaagctctggattactgccacagcaagggaatcatgcacagggatgtgaaacct
cacaatgtcatgatagatcaccaacagaaaaagctgcgactgatagattggggtctggca
gaattctatcatcctgctcaggagtacaatgttcgtgtagcctcaaggtacttcaaggga
ccagagctcctcgtggactatcagatgtatgattatagcttggacatgtggagtttgggc
tgtatgttagcaagcatgatctttcgaagggaaccattcttccatggacaggacaactat
gaccagcttgttcgcattgccaaggttctgggtacagaagaactgtatgggtatctgaag
aagtatcacatagacctagatccacacttcaacgatatcctgggacaacattcacggaaa
cgctgggaaaactttatccatagtgagaacagacaccttgtcagccctgaggccctagat
cttctggacaaacttctgcgatacgaccatcaacagagactgactgccaaagaggccatg
gagcacccatacttctaccctgtggtgaaggagcagtcccagccttgtgcagacaatgct
gtgctttccagtggtctcacggcagcacgatga

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