| | NETWORK: N01202 | |
Entry |
|
Name |
Oligomeric conformation PrPc to anterograde axonal transport
|
Definition |
PRNP* -> (GSK3B,CK2) -| (KIF5+KLC) |
Expanded |
5621v2 -> (2932,1457,1459,1460,283106) -| ((3798,3799,3800)+(3831,64837,147700,89953)) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
2932 | GSK3B; glycogen synthase kinase 3 beta |
1457 | CSNK2A1; casein kinase 2 alpha 1 |
1459 | CSNK2A2; casein kinase 2 alpha 2 |
1460 | CSNK2B; casein kinase 2 beta |
283106 | CSNK2A3; casein kinase 2 alpha 3 |
3798 | KIF5A; kinesin family member 5A |
3799 | KIF5B; kinesin family member 5B |
3800 | KIF5C; kinesin family member 5C |
3831 | KLC1; kinesin light chain 1 |
64837 | KLC2; kinesin light chain 2 |
147700 | KLC3; kinesin light chain 3 |
89953 | KLC4; kinesin light chain 4 |
|
Variant |
5621v2 (PRNP*) PRNP oligomeric conformation
|
Reference |
|
Authors |
Zamponi E, Pigino GF |
Title |
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases. |
Journal |
|
Reference |
|
Authors |
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF |
Title |
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. |
Journal |
|
LinkDB |
|
|
|