Entry
Symbol
DBH, DBM, ORTHYP1
Name
(RefSeq) dopamine beta-hydroxylase
KO
Organism
Pathway
Module
hsa_M00042 Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Network
nt06028 Dopamine and serotonin metabolism
nt06544 Neuroactive ligand signaling
Element
N01919 Dopamine/Adrenaline metabolism in presynaptic neuron
Disease
H01005 Dopamine beta-hydroxylase deficiency
H02751 Orthostatic hypotension
Drug target
Nepicastat hydrochloride: D03787
Brite
KEGG Orthology (KO) [BR:hsa00001 ]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
1621 (DBH)
Enzymes [BR:hsa01000 ]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
1.14.17.1 dopamine beta-monooxygenase
1621 (DBH)
BRITE hierarchy
SSDB
Ortholog Paralog Gene cluster GFIT
Motif
Motif
Other DBs
Structure
PDB PDBj
LinkDB
All DBs
Position
9:133636363..133659329
Genome browser
AA seq
617 aa AA seq DB search
MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLE
LSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQK
GQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSL
EAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKG
FSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLA
AWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRF
NAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKV
VTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGG
FGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFT
SVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQ
GRSPAGPTVVSIGGGKG
NT seq
1854 nt NT seq +upstream nt +downstream nt
atgcccgccctcagtcgctgggccagcctgcccggccccagcatgcgggaggcagccttc
atgtacagcacagcagtggccatcttcctggtcatcctggtggccgcactgcagggctcg
gctccccgtgagagccccctcccctatcacatccccctggacccggaggggtccctggag
ctctcatggaatgtcagctacacccaggaggccatccatttccagctcctggtgcggagg
ctcaaggctggcgtcctgtttgggatgtccgaccgtggcgagcttgagaacgcagatctc
gtggtgctctggaccgatggggacactgcctattttgcggacgcctggagtgaccagaag
gggcagatccacctggatccccagcaggactaccagctgctgcaggtgcagaggacccca
gaaggcctgaccctgcttttcaagaggccctttggcacctgcgaccccaaggattacctc
attgaagacggcactgtccacttggtctacgggatcctggaggagccgttccggtcactg
gaggccatcaacggctcgggcctgcagatggggctgcagagggtgcagctcctgaagccc
aatatccccgaaccggagttgccctcagacgcgtgcaccatggaggtccaagctcccaat
atccagatccccagccaggagaccacgtactggtgctacattaaggagcttccaaagggc
ttctctcggcaccacattatcaagtacgagcccatcgtcaccaagggcaatgaggccctt
gtccaccacatggaagtcttccagtgcgcccccgagatggacagcgtcccccacttcagc
gggccctgcgactccaagatgaaacccgaccgcctcaactactgccgccacgtgctggcc
gcctgggccctgggtgccaaggcattttactacccagaggaagccggccttgccttcggg
ggtccagggtcctccagatatctccgcctggaagttcactaccacaacccactggtgata
gaaggacgaaacgactcctcaggcatccgcttgtactacacagccaagctgcggcgcttc
aacgcggggatcatggagctgggactggtgtacacgccagtgatggccattccaccacgg
gagaccgccttcatcctcactggctactgcacggacaagtgcacccagctggcactgcct
ccctccgggatccacatcttcgcctctcagctccacacacacctgactgggagaaaggtg
gtcacagtgctggtccgggacggccgggagtgggagatcgtgaaccaggacaatcactac
agccctcacttccaggagatccgcatgttgaagaaggtcgtgtcggtccatccgggagat
gtgctcatcacctcctgcacgtacaacacagaagaccgggagctggccacagtggggggc
ttcgggatcctggaggagatgtgtgtcaactacgtgcactactacccccagacgcagctg
gagctctgcaagagcgctgtggacgccggcttcctgcagaagtacttccacctcatcaac
aggttcaacaacgaggatgtctgcacctgccctcaggcgtccgtgtctcagcagttcacc
tctgttccctggaactccttcaaccgcgacgtactgaaggccctgtacagcttcgcgccc
atctccatgcactgcaacaagtcctcagccgtccgcttccagggtgaatggaacctgcag
cccctgcccaaggtcatctccacactggaagagcccaccccacagtgccccaccagccag
ggccgaagccctgctggccccaccgttgtcagcattggtgggggcaaaggctga