| Entry |
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| Name |
Dopamine/Adrenaline metabolism in presynaptic neuron
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| Definition |
Dopamine -- DBH -> Noradrenaline -- PNMT -> Adrenaline -- COMT >> MAO -> MHPG |
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| Expanded |
C03758 -- 1621 -> C00547 -- 5409 -> C00788 -- 1312 >> (4128,4129) -> C05583 |
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| Class |
nt06544 Neuroactive ligand signaling
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| Type |
Reference
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| Pathway |
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| Gene |
| 1621 | DBH; dopamine beta-hydroxylase |
| 5409 | PNMT; phenylethanolamine N-methyltransferase |
| 1312 | COMT; catechol-O-methyltransferase |
| 4128 | MAOA; monoamine oxidase A |
| 4129 | MAOB; monoamine oxidase B |
|
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| Metabolite |
| C05583 | 3-Methoxy-4-hydroxyphenylglycolaldehyde |
|
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| Reference |
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| Authors |
Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V |
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| Title |
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications. |
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| Journal |
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| Reference |
|
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| Authors |
Montoya A, Bruins R, Katzman MA, Blier P |
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| Title |
The noradrenergic paradox: implications in the management of depression and anxiety. |
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| Journal |
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| Reference |
|
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| Authors |
Holland N, Robbins TW, Rowe JB |
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| Title |
The role of noradrenaline in cognition and cognitive disorders. |
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| Journal |
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| LinkDB |
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