Homo sapiens (human): 1643
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Entry
1643 CDS
T01001
Symbol
DDB2, DDBB, UV-DDB2, XPE
Name
(RefSeq) damage specific DNA binding protein 2
KO
K10140
DNA damage-binding protein 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa03420
Nucleotide excision repair
hsa04115
p53 signaling pathway
hsa04120
Ubiquitin mediated proteolysis
hsa05161
Hepatitis B
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05216
Thyroid cancer
hsa05217
Basal cell carcinoma
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
Network
nt06165
Epstein-Barr virus (EBV)
nt06240
Transcription (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06269
Basal cell carcinoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06273
Glioma
nt06274
Thyroid cancer
nt06276
Chronic myeloid leukemia
nt06502
Nucleotide excision repair
Element
N00115
Mutation-inactivated TP53 to transcription
N00223
EBV EBNA1 to p53-mediated transcription
N00263
EBV EBNA3C to p53-mediated transcription
N00481
EBV BZLF1 to p53-mediated transcription
N01425
Global genome NER
Disease
H00403
Disorders of nucleotide excision repair
H01428
Xeroderma pigmentosum
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
1643 (DDB2)
09124 Replication and repair
03420 Nucleotide excision repair
1643 (DDB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1643 (DDB2)
05202 Transcriptional misregulation in cancer
1643 (DDB2)
09162 Cancer: specific types
05210 Colorectal cancer
1643 (DDB2)
05212 Pancreatic cancer
1643 (DDB2)
05225 Hepatocellular carcinoma
1643 (DDB2)
05226 Gastric cancer
1643 (DDB2)
05214 Glioma
1643 (DDB2)
05216 Thyroid cancer
1643 (DDB2)
05220 Chronic myeloid leukemia
1643 (DDB2)
05217 Basal cell carcinoma
1643 (DDB2)
05218 Melanoma
1643 (DDB2)
05213 Endometrial cancer
1643 (DDB2)
05224 Breast cancer
1643 (DDB2)
05222 Small cell lung cancer
1643 (DDB2)
05223 Non-small cell lung cancer
1643 (DDB2)
09172 Infectious disease: viral
05161 Hepatitis B
1643 (DDB2)
05169 Epstein-Barr virus infection
1643 (DDB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
1643 (DDB2)
03400 DNA repair and recombination proteins [BR:
hsa03400
]
1643 (DDB2)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit Ring-finger type E3
Cul4 complex
Target recognizing subunit (DCAF)
1643 (DDB2)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
NER (nucleotide excision repair)
GGR (global genome repair) factors
Cul4-DDB2 complex
1643 (DDB2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
WD40
WD40_Prp19
WD40_WDHD1_1st
WD40_CDC20-Fz
Beta-prop_WDR75_1st
Beta-prop_EML_2
WDR55
Beta-prop_WDR90_POC16_2nd
Beta-prop_RIG_2nd
Beta-prop_EIPR1
Beta-prop_IFT140_1st
EIF3I
Beta-prop_TEP1_2nd
Beta-prop_WDR19_1st
Beta-prop_HPS5
Beta-prop_CAF1B_HIR1
Beta-prop_TEP1_C
WD40_MABP1-WDR62_2nd
NBCH_WD40
WD40_RFWD3
Beta-prop_EML
Beta-prop_Vps41
WD_LRWD1
Motif
Other DBs
NCBI-GeneID:
1643
NCBI-ProteinID:
NP_000098
OMIM:
600811
HGNC:
2718
Ensembl:
ENSG00000134574
UniProt:
Q92466
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:47214454..47239217
Genome browser
AA seq
427 aa
AA seq
DB search
MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP
QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH
PTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT
TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM
HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG
ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN
FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ
EEARTRK
NT seq
1284 nt
NT seq
+upstream
nt +downstream
nt
atggctcccaagaaacgcccagaaacccagaagacctccgagattgtattacgccccagg
aacaagaggagcaggagtcccctggagctggagcccgaggccaagaagctctgtgcgaag
ggctccggtcctagcagaagatgtgactcagactgcctctgggtggggctggctggccca
cagatcctgccaccatgccgcagcatcgtcaggaccctccaccagcataagctgggcaga
gcttcctggccatctgtccagcaggggctccagcagtcctttttgcacactctggattct
taccggatattacaaaaggctgccccctttgacaggagggctacatccttggcgtggcac
ccaactcaccccagcaccgtggctgtgggttccaaagggggagatatcatgctctggaat
tttggcatcaaggacaaacccaccttcatcaaagggattggagctggagggagcatcact
gggctgaagtttaaccctctcaataccaaccagttttacgcctcctcaatggagggaaca
actaggctgcaagactttaaaggcaacattctacgagtttttgccagctcagacaccatc
aacatctggttttgtagcctggatgtgtctgctagtagccgaatggtggtcacaggagac
aacgtggggaacgtgatcctgctgaacatggacggcaaagagctttggaatctcagaatg
cacaaaaagaaagtgacgcatgtggccctgaacccatgctgtgattggttcctggccaca
gcctccgtagatcaaacagtgaaaatttgggacctgcgccaggttagagggaaagccagc
ttcctctactcgctgccgcacaggcatcctgtcaacgcagcttgtttcagtcccgatgga
gcccggctcctgaccacggaccagaagagcgagatccgagtttactctgcttcccagtgg
gactgccccctgggcctgatcccgcaccctcaccgtcacttccagcacctcacacccatc
aaggcagcctggcatcctcgctacaacctcattgttgtgggccgatacccagatcctaat
ttcaaaagttgtaccccttatgaattgaggacgatcgacgtgttcgatggaaactcaggg
aagatgatgtgtcagctctatgacccagaatcttctggcatcagttcgcttaatgaattc
aatcccatgggggacacgctggcctctgcaatgggttaccacattctcatctggagccag
gaggaagccaggacacggaagtga
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