| Entry |
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| Name |
EBV EBNA3C to p53-mediated transcription
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| Definition |
EBNA3C -> MDM2 -| TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK) |
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| Expanded |
K19458 -> 4193 -| 7157 => (1026,1647,4616,10912,581,578,1643,51426) |
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| Class |
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| Type |
Pathogen
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| Pathway |
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| Disease |
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| Gene |
| 4193 | MDM2; MDM2 proto-oncogene |
| 7157 | TP53; tumor protein p53 |
| 1026 | CDKN1A; cyclin dependent kinase inhibitor 1A |
| 1647 | GADD45A; growth arrest and DNA damage inducible alpha |
| 4616 | GADD45B; growth arrest and DNA damage inducible beta |
| 10912 | GADD45G; growth arrest and DNA damage inducible gamma |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 1643 | DDB2; damage specific DNA binding protein 2 |
| 51426 | POLK; DNA polymerase kappa |
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| Perturbant |
| K19458 (EBNA3C) | EBNA6; EBV nuclear antigen 6 |
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| Reference |
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| Authors |
Saha A, Robertson ES |
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| Title |
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes. |
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| Journal |
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| Reference |
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| Authors |
Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E |
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| Title |
Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical. |
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| Journal |
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| Reference |
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| Authors |
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM |
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| Title |
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers. |
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| Journal |
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| Reference |
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| Authors |
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES |
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| Title |
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. |
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| Journal |
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| Reference |
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| Authors |
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES |
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| Title |
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities. |
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| Journal |
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| LinkDB |
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