| Entry |
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| Name |
Mutation-inactivated TP53 to transcription
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| Definition |
TP53* // (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK) |
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| Expanded |
7157v1 // (1026,1647,4616,10912,581,578,1643,51426) |
|---|
| Class |
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|---|
| Type |
Variant
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|---|
| Pathway |
|
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| Disease |
| H00048 | Hepatocellular carcinoma |
| H00004 | Chronic myeloid leukemia |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 7157 | TP53; tumor protein p53 |
| 1026 | CDKN1A; cyclin dependent kinase inhibitor 1A |
| 1647 | GADD45A; growth arrest and DNA damage inducible alpha |
| 4616 | GADD45B; growth arrest and DNA damage inducible beta |
| 10912 | GADD45G; growth arrest and DNA damage inducible gamma |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 1643 | DDB2; damage specific DNA binding protein 2 |
| 51426 | POLK; DNA polymerase kappa |
|
|---|
| Variant |
|
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| Reference |
|
|---|
| Authors |
Kirsch DG, Kastan MB |
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| Title |
Tumor-suppressor p53: implications for tumor development and prognosis. |
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| Journal |
|
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| Reference |
|
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| Authors |
Fridman JS, Lowe SW |
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| Title |
Control of apoptosis by p53. |
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| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Tokino T, Nakamura Y. |
|---|
| Title |
The role of p53-target genes in human cancer. |
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| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Reed SM, Quelle DE |
|---|
| Title |
p53 Acetylation: Regulation and Consequences. |
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| Journal |
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| LinkDB |
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