Homo sapiens (human): 1649
Help
Entry
1649 CDS
T01001
Symbol
DDIT3, AltDDIT3, C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
Name
(RefSeq) DNA damage inducible transcript 3
KO
K04452
DNA damage-inducible transcript 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04932
Non-alcoholic fatty liver disease
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05202
Transcriptional misregulation in cancer
hsa05417
Lipid and atherosclerosis
Network
nt06240
Transcription (cancer)
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06534
Unfolded protein response
Element
N00139
FUS-DDIT3 fusion to CEBPB-mediated transcription
N00140
FUS-DDIT3 fusion to NFKB-mediated transcription
N01009
PERK-ATF4 signaling pathway
N01010
Mutation-caused aberrant PSEN1 to PERK-ATF4 signaling pathway
N01011
IRE1a-XBP1 signaling pathway
N01015
ATF6-mediated transcription
N01016
Mutation-caused aberrant PSEN1 to ATF6-mediated transcription
N01033
Mutation-caused aberrant SNCA to ATF6-mediated transcription
N01035
Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
N01147
Mutation-caused aberrant SOD1 to ATF6-mediated transcription
N01149
Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
N01198
Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
Disease
H00049
Myxoid liposarcoma
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
1649 (DDIT3)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
1649 (DDIT3)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
1649 (DDIT3)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
1649 (DDIT3)
09164 Neurodegenerative disease
05010 Alzheimer disease
1649 (DDIT3)
05012 Parkinson disease
1649 (DDIT3)
05014 Amyotrophic lateral sclerosis
1649 (DDIT3)
05020 Prion disease
1649 (DDIT3)
05022 Pathways of neurodegeneration - multiple diseases
1649 (DDIT3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
1649 (DDIT3)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
1649 (DDIT3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
1649 (DDIT3)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Basic leucine zipper (bZIP)
C/EBP-like factors
1649 (DDIT3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
bZIP_2
bZIP_1
GAS
DivIC
NAM-associated
AC_N
DASH_Spc19
Fungal_TACC
CLZ
DUF5595
bZIP_Maf
RR_TM4-6
WDCP
Gcd10p
DUF5094
CDC45
IFP_35_N
Motif
Other DBs
NCBI-GeneID:
1649
NCBI-ProteinID:
NP_001181986
OMIM:
126337
HGNC:
2726
Ensembl:
ENSG00000175197
UniProt:
P35638
Q53YD1
LinkDB
All DBs
Position
12:complement(57516588..57520517)
Genome browser
AA seq
169 aa
AA seq
DB search
MAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASL
AWLTEEEPEPAEVTSTSQSPHSPDSSQSSLAQEEEEEDQGRTRKRKQSGHSPARAGKQRM
KEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA
NT seq
510 nt
NT seq
+upstream
nt +downstream
nt
atggcagctgagtcattgcctttctccttcgggacactgtccagctgggagctggaagcc
tggtatgaggacctgcaagaggtcctgtcttcagatgaaaatgggggtacctatgtttca
cctcctggaaatgaagaggaagaatcaaaaatcttcaccactcttgaccctgcttctctg
gcttggctgactgaggaggagccagaaccagcagaggtcacaagcacctcccagagccct
cactctccagattccagtcagagctccctggctcaggaggaagaggaggaagaccaaggg
agaaccaggaaacggaaacagagtggtcattccccagcccgggctggaaagcagcgcatg
aaggagaaagaacaggagaatgaaaggaaagtggcacagctagctgaagagaatgaacgg
ctcaagcaggaaatcgagcgcctgaccagggaagtagaggcgactcgccgagctctgatt
gaccgaatggtgaatctgcaccaagcatga
Homo sapiens (human): 7494
Help
Entry
7494 CDS
T01001
Symbol
XBP1, TREB-5, TREB5, XBP-1, XBP2
Name
(RefSeq) X-box binding protein 1
KO
K09027
X box-binding protein 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04141
Protein processing in endoplasmic reticulum
hsa04932
Non-alcoholic fatty liver disease
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05417
Lipid and atherosclerosis
Network
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06534
Unfolded protein response
Element
N01011
IRE1a-XBP1 signaling pathway
N01012
Mutation-caused aberrant PSEN1 to IRE1a-XBP1 signaling pathway
N01015
ATF6-mediated transcription
N01016
Mutation-caused aberrant PSEN1 to ATF6-mediated transcription
N01034
Mutation-caused aberrant SNCA to IRE1a-XBP1 signaling pathway
N01148
Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway
Disease
H01653
Bipolar disorder
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
7494 (XBP1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
7494 (XBP1)
05012 Parkinson disease
7494 (XBP1)
05014 Amyotrophic lateral sclerosis
7494 (XBP1)
05017 Spinocerebellar ataxia
7494 (XBP1)
05022 Pathways of neurodegeneration - multiple diseases
7494 (XBP1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
7494 (XBP1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
7494 (XBP1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
7494 (XBP1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Basic leucine zipper (bZIP)
AP-1(-like) components, Jun
7494 (XBP1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
bZIP_1
bZIP_2
bZIP_Maf
KASH_CCD
YabA
DUF2408
Motif
Other DBs
NCBI-GeneID:
7494
NCBI-ProteinID:
NP_005071
OMIM:
194355
HGNC:
12801
Ensembl:
ENSG00000100219
UniProt:
P17861
Structure
PDB
LinkDB
All DBs
Position
22:complement(28794560..28800569)
Genome browser
AA seq
261 aa
AA seq
DB search
MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARK
RQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLR
EKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQL
SPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVP
YQPPFLCQWGRHQPSWKPLMN
NT seq
786 nt
NT seq
+upstream
nt +downstream
nt
atggtggtggtggcagccgcgccgaacccggccgacgggacccctaaagttctgcttctg
tcggggcagcccgcctccgccgccggagccccggccggccaggccctgccgctcatggtg
ccagcccagagaggggccagcccggaggcagcgagcggggggctgccccaggcgcgcaag
cgacagcgcctcacgcacctgagccccgaggagaaggcgctgaggaggaaactgaaaaac
agagtagcagctcagactgccagagatcgaaagaaggctcgaatgagtgagctggaacag
caagtggtagatttagaagaagagaaccaaaaacttttgctagaaaatcagcttttacga
gagaaaactcatggccttgtagttgagaaccaggagttaagacagcgcttggggatggat
gccctggttgctgaagaggaggcggaagccaaggggaatgaagtgaggccagtggccggg
tctgctgagtccgcagcactcagactacgtgcacctctgcagcaggtgcaggcccagttg
tcacccctccagaacatctccccatggattctggcggtattgactcttcagattcagagt
ctgatatcctgttgggcattctggacaacttggacccagtcatgttcttcaaatgccctt
ccccagagcctgccagcctggaggagctcccagaggtctacccagaaggacccagttcct
taccagcctccctttctctgtcagtggggacgtcatcagccaagctggaagccattaatg
aactaa
Homo sapiens (human): 3309
Help
Entry
3309 CDS
T01001
Symbol
HSPA5, BIP, GRP78, HEL-S-89n
Name
(RefSeq) heat shock protein family A (Hsp70) member 5
KO
K09490
endoplasmic reticulum chaperone BiP [EC:
3.6.4.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03060
Protein export
hsa04141
Protein processing in endoplasmic reticulum
hsa04612
Antigen processing and presentation
hsa04918
Thyroid hormone synthesis
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05417
Lipid and atherosclerosis
Network
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06534
Unfolded protein response
Element
N01015
ATF6-mediated transcription
N01033
Mutation-caused aberrant SNCA to ATF6-mediated transcription
N01034
Mutation-caused aberrant SNCA to IRE1a-XBP1 signaling pathway
N01035
Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
N01147
Mutation-caused aberrant SOD1 to ATF6-mediated transcription
N01148
Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway
N01149
Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
N01198
Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03060 Protein export
3309 (HSPA5)
04141 Protein processing in endoplasmic reticulum
3309 (HSPA5)
09150 Organismal Systems
09151 Immune system
04612 Antigen processing and presentation
3309 (HSPA5)
09152 Endocrine system
04918 Thyroid hormone synthesis
3309 (HSPA5)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
3309 (HSPA5)
05014 Amyotrophic lateral sclerosis
3309 (HSPA5)
05020 Prion disease
3309 (HSPA5)
05022 Pathways of neurodegeneration - multiple diseases
3309 (HSPA5)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3309 (HSPA5)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
3309 (HSPA5)
04131 Membrane trafficking [BR:
hsa04131
]
3309 (HSPA5)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3309 (HSPA5)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.6 Acting on acid anhydrides
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.4.10 non-chaperonin molecular chaperone ATPase
3309 (HSPA5)
Chaperones and folding catalysts [BR:
hsa03110
]
Heat shock proteins
HSP70 / DNAK
3309 (HSPA5)
Membrane trafficking [BR:
hsa04131
]
Endoplasmic reticulum (ER) - Golgi transport
Forward pathways
ER-Golgi intermediate compartment (ERGIC) proteins
3309 (HSPA5)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3309 (HSPA5)
Exosomal proteins of other body fluids (saliva and urine)
3309 (HSPA5)
Exosomal proteins of colorectal cancer cells
3309 (HSPA5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HSP70
MreB_Mbl
Hydantoinase_A
FtsA
DDR
FGGY_C
ParM_N
Tombus_movement
Motif
Other DBs
NCBI-GeneID:
3309
NCBI-ProteinID:
NP_005338
OMIM:
138120
HGNC:
5238
Ensembl:
ENSG00000044574
UniProt:
P11021
V9HWB4
Structure
PDB
LinkDB
All DBs
Position
9:complement(125234853..125241343)
Genome browser
AA seq
654 aa
AA seq
DB search
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
NT seq
1965 nt
NT seq
+upstream
nt +downstream
nt
atgaagctctccctggtggccgcgatgctgctgctgctcagcgcggcgcgggccgaggag
gaggacaagaaggaggacgtgggcacggtggtcggcatcgacctggggaccacctactcc
tgcgtcggcgtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgc
atcacgccgtcctatgtcgccttcactcctgaaggggaacgtctgattggcgatgccgcc
aagaaccagctcacctccaaccccgagaacacggtctttgacgccaagcggctcatcggc
cgcacgtggaatgacccgtctgtgcagcaggacatcaagttcttgccgttcaaggtggtt
gaaaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacattt
gctcctgaagaaatttctgccatggttctcactaaaatgaaagaaaccgctgaggcttat
ttgggaaagaaggttacccatgcagttgttactgtaccagcctattttaatgatgcccaa
cgccaagcaaccaaagacgctggaactattgctggcctaaatgttatgaggatcatcaac
gagcctacggcagctgctattgcttatggcctggataagagggagggggagaagaacatc
ctggtgtttgacctgggtggcggaaccttcgatgtgtctcttctcaccattgacaatggt
gtcttcgaagttgtggccactaatggagatactcatctgggtggagaagactttgaccag
cgtgtcatggaacacttcatcaaactgtacaaaaagaagacgggcaaagatgtcaggaaa
gacaatagagctgtgcagaaactccggcgcgaggtagaaaaggccaaacgggccctgtct
tctcagcatcaagcaagaattgaaattgagtccttctatgaaggagaagacttttctgag
accctgactcgggccaaatttgaagagctcaacatggatctgttccggtctactatgaag
cccgtccagaaagtgttggaagattctgatttgaagaagtctgatattgatgaaattgtt
cttgttggtggctcgactcgaattccaaagattcagcaactggttaaagagttcttcaat
ggcaaggaaccatcccgtggcataaacccagatgaagctgtagcgtatggtgctgctgtc
caggctggtgtgctctctggtgatcaagatacaggtgacctggtactgcttgatgtatgt
ccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaac
acagtggtgcctaccaagaagtctcagatcttttctacagcttctgataatcaaccaact
gttacaatcaaggtctatgaaggtgaaagacccctgacaaaagacaatcatcttctgggt
acatttgatctgactggaattcctcctgctcctcgtggggtcccacagattgaagtcacc
tttgagatagatgtgaatggtattcttcgagtgacagctgaagacaagggtacagggaac
aaaaataagatcacaatcaccaatgaccagaatcgcctgacacctgaagaaatcgaaagg
atggttaatgatgctgagaagtttgctgaggaagacaaaaagctcaaggagcgcattgat
actagaaatgagttggaaagctatgcctattctctaaagaatcagattggagataaagaa
aagctgggaggtaaactttcctctgaagataaggagaccatggaaaaagctgtagaagaa
aagattgaatggctggaaagccaccaagatgctgacattgaagacttcaaagctaagaag
aaggaactggaagaaattgttcaaccaattatcagcaaactctatggaagtgcaggccct
cccccaactggtgaagaggatacagcagaaaaagatgagttgtag
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