Homo sapiens (human): 2312 Help Entry 2312              CDS       T01001                                  Symbol FLG, ATOD2, FLG-1, FLG1 Name (RefSeq) filaggrin   KO K10384   filaggrin Organism hsa  Homo sapiens (human) Pathway hsa04382   Cornified envelope formation Network nt06545  Cornified envelope formation   Element N01930   Processing of profilaggrin to filaggrin and binding to keratin filaments N01931   Processing of filaggrin to amino acids Disease H00735   Ichthyosis vulgaris H01358   Atopic dermatitis Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09158 Development and regeneration    04382 Cornified envelope formation     2312 (FLG)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     2312 (FLG) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Intermediate filaments    Intermediate filament-binding proteins     2312 (FLG) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Filaggrin S_100 EF-hand_7 YqzH EF-hand_1 Motif Other DBs NCBI-GeneID:  2312 NCBI-ProteinID:  NP_002007 OMIM:  135940 HGNC:  3748 Ensembl:  ENSP00000357789.1 UniProt:  P20930 Structure PDBPDBj LinkDB All DBs Position 1:complement(152302165..152325239) Genome browser AA seq 4061 aa AA seqDB search MSTLLENIFAIINLFKQYSKKDKNTDTLSKKELKELLEKEFRQILKNPDDPDMVDVFMDH LDIDHNKKIDFTEFLLMVFKLAQAYYESTRKENLPISGHKHRKHSHHDKHEDNKQEENKE NRKRPSSLERRNNRKGNKGRSKSPRETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNS SKKEKNKTENTRLGDNRKRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQ DEAYDTTDSLLEENKIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQD RDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRH AETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGS QASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDS AHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSG HSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRH SQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSRDGSRHP RSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADSS RHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESAR DRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDT IRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEE QSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSE RWSGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAAS SHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEE SDTQSVSGHGQDGPHQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGR RQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTS QGRSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGS RTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHG HSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASS AVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSRS FLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGR QGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSR HHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYG SAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGER HGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQA GPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDS SRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSG SRSVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQ DSDSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTR HTESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYS GSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQS ESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDR SGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSS RHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSR HPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADS SRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQEST RGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQD TIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRND EQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDS ERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAA SSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSE DSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTR GRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTT SQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEG SRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGH GHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQAS SAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSG SFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGG RQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVS RHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHR GSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGE RHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQ AGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARD SSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQS GSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVS QDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGT HHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSS GSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQS ESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDR SGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSS RHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSR HPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHSGIQSRGSPHSSSSYHYQS EGTERQKGQSGLVWRHGSYGSADYDYGESGFRHSQHGSVSYNSNPVVFKERSDICKASAF GKDHPRYYATYINKDPGLCGHSSDISKQLGFSQSQRYYYYE NT seq 12186 nt NT seq  +upstreamnt  +downstreamnt atgtctactctcctggaaaacatctttgccataattaatcttttcaagcaatattcaaaa aaagataaaaacactgacacattgagtaaaaaagagctgaaggaacttctggaaaaggaa tttcggcaaatcctgaagaatccagatgacccagatatggttgatgtcttcatggatcac ttggatatagaccacaacaagaaaattgacttcactgagtttcttctgatggtattcaag ttggctcaagcatattatgagtctaccagaaaagagaatttaccgatatcaggacacaag cacagaaagcacagtcatcatgataaacatgaagataataaacaggaagaaaacaaagaa aacagaaaaagaccctcaagtctggaaagaagaaacaatagaaaagggaataagggaaga tccaagagcccaagagaaacaggggggaaaaggcatgaatctagttctgaaaaaaaagaa agaaaaggatattcacctactcatagagaagaagaatatggaaaaaaccatcataactca agtaaaaaagagaaaaacaagactgaaaatactagattaggagacaataggaagaggcta agtgaaagacttgaagagaaagaagacaatgaagaaggagtatatgattatgaaaataca ggaagaatgactcaaaaatggatacaatcaggccatattgccacatattacacaatccag gatgaagcctatgacaccactgatagtctattagaagaaaacaaaatatatgaaagatca aggtcatctgatggcaaatcatcatctcaagtgaacaggtcaagacatgaaaatacaagc caggtaccattgcaggagtccaggacaagaaagcgtaggggatccagagttagccaggac agggacagtgagggacactcagaagactctgagaggcactctgggtcggcttccagaaac catcatggatctgcgtgggagcagtcaagagatggctccagacaccccaggtcccatgat gaagacagagccagtcatgggcactctgcagacagctccagacaatcaggcactcgtcac gcagagacttcctctcgtggacagactgcatcatcccatgaacaggcaagatcaagtcca ggagaaagacatggatccggccaccagcagtcagcagacagctccagacactcagccact gggcgcgggcaagcttcatctgcagtcagcgatcgtggacaccgggggtctagcggtagt caggccagtgacagtgagggacattcagaaaactcagacacacaatcagtgtcaggccac ggaaaggctgggctgagacagcagagccaccaagagtccacacgtggccggtcaggggaa cggtctggacgttcagggtcttccctctaccaggtgagcactcatgaacagcctgactct gcccatggacggaccgggaccagcactggaggaagacaaggatcgcaccacgagcaggca cgagacagctccaggcattcagcgtcccaagagggtcaggacaccattcgtggacacccg gggtcaagcagaggaggaaggcagggatcccaccacgagcaatcggtaaataggtctgga cactcaggttcccatcacagccacaccacatcccagggaaggtctgatgcctcccatggg cagtcaggatccagaagtgcaagcagacaaacacgaaatgaggaacaatcaggagacggc accaggcactcagggtcacgtcatcatgaagcttcctctcaggctgacagctctagacac tcacaggtgggccagggacaatcatcggggcccaggacaagtaggaaccagggatccagt gttagccaggacagtgacagtcagggacactcagaagactctgagaggtggtctgggtct gcttccagaaaccatcatggatctgctcaggagcagtcaagagatggctccagacacccc aggtcccatcacgaagacagagctggtcatgggcactctgcagacagctccagaaaatca ggcactcgtcacacacagaattcctctagtggacaggctgcgtcatcccatgaacaggca agatcaagtgcaggagaaagacatggatcccgccaccagctccagtcagcagacagctcc agacactcaggcactgggcacggacaagcttcatctgcagtcagagacagtggacaccga gggtccagtggtagtcaggccactgacagtgagggacattcagaagactcagacacacag tcagtgtcaggccatggacaggctggtcaccatcagcagagccaccaagagtccgcacgt gaccggtcaggggaaaggtctcgacgttcagggtctttcctctaccaggtgagcactcat aaacagtctgagtcctcccatggatggacagggcccagcactggagtaagacaaggatcc caccatgagcaggcacgagacaactccaggcactcagcatcccaagatggtcaggacacc attcgtggacacccggggtcaagcagaagaggaaggcaggggtcccaccacgagcaatcg gtagataggtctggacactcagggtcccatcacagccacaccacatcccagggaaggtct gatgcctcccgtgggcagtcaggatccagaagtgcaagcagaacaacacgtaatgaggaa caatcaagagacggctccaggcactcagggtcacgtcaccatgaagcttcctctcatgcc gacatctctagacactcacaggcaggccagggacaatcagaggggtccaggacaagcagg cgccagggatccagtgttagccaggacagtgacagtgagggacattcagaagactctgag aggtggtctgggtctgcttccagaaaccatcgtggatctgctcaggagcagtcaagacat ggctccagacaccccaggtcccatcacgaagacagagccggtcacgggcactctgcagac agctccagacaatcaggaactcctcacgcagagacttcctctggtggacaggctgcgtca tcccatgaacaggcaagatcaagtccaggagaaagacacggatcccgccaccagcagtca gcagacagctccagacactcaggcattccgcgcagacaagcttcatctgcagtcagagac agtggacactgggggtccagtggtagtcaggccagtgatagtgagggacattcagaggag tcagacacacagtcagtgtcaggccatggacaggatgggccccatcagcagagccaccaa gagtccgcacgtgactggtcagggggaaggtctggacgttcagggtctttcatctaccag gtgagcactcatgaacagtctgagtctgcccatgggcggaccaggaccagcactggacga agacaaggatcccaccacgagcaggcacgagacagctccaggcactcagcgtcccaagag ggtcaggacaccattcgtgcacacccggggtcaaggagaggaggaaggcagggatcccac catgagcaatcggtagatagatctggacactcagggtcccatcacagccacaccacatcc cagggaaggtctgatgcctcccatgggcagtcaggatccagaagtgcaagcagacaaact cgtaaggacaaacaatcaggagacggctccaggcactcagggtcacgtcaccatgaagct gcctcttgggctgacagctctagacactcacaggtgggacaggaacaatcatcggggtcc aggacaagcaggcaccagggatccagtgttagccaggacagtgacagtgagagacactca gacgactccgagaggttgtctgggtctgcttccagaaaccatcatggatcttctcgggag cagtcaagagatggctccagacaccctgggttccatcaagaagacagagccagtcacggg cactctgcagacagctccagacaatcaggcactcatcacacagagtcttcctctcatgga caggctgtgtcatcccatgaacaggcaagatcaagtccaggagaaagacatggatcccgc caccagcagtcagcagacagctccagacactcaggcattgggcacagacaagcttcatct gcagtcagagacagtggacaccgagggtccagtggtagtcaggtcactaacagtgaggga cattcagaagactcagacacacagtcagtgtcagcccacggacaagctgggccccatcag cagagccacaaagagtccgcacgtggccagtcaggggaaagctctggacgttcaaggtct ttcctctaccaggtgagctctcatgaacagtctgagtccacacacggacagactgcaccc agcactggaggaagacaaggatcccgccatgagcaggcacgaaacagctctaggcactca gcatcccaagacggtcaggacaccattcgtggacacccggggtcaagcagaggaggaagg cagggatcctaccacgagcaatcagtagataggtctggacactcagggtaccatcacagc cacaccacaccccagggaaggtctgatgcctcccatgggcagtcaggacccagaagtgca agcaggcaaacaagaaatgaggaacaatcaggagacggctccaggcactcagggtcacgt caccatgaaccttccactcgggccggcagctctagacactcacaggtgggccagggagaa tcagcggggtccaagacaagcaggcgccagggatccagtgttagtcaggacagggacagt gagggacactcagaagactctgagaggcggtctgagtcggcttccagaaaccattatgga tctgctcgggagcagtcaagacatggctccaggaaccccaggtcccatcaagaagataga gccagtcatgggcactctgcagagagctccagacaatcaggcactcgtcatgcagagact tcctctggtggacaggctgcatcatcccaggaacaggcaaggtcaagtccaggagaaaga catggatcccgccaccagcagtcagcagacagctccacagactcaggcactgggcgcaga caagattcatctgtagtcggagacagtggaaaccgagggtccagtggtagccaggccagt gacagcgagggacactcagaagagtcagacacacagtcagtgtcagcccacggacaggct gggccccatcagcagagccaccaagagtccacacgtggccagtcaggggaaaggtctgga cgttcagggtctttcctctaccaggtgagcactcatgaacagtctgagtccgcccatgga cgcacagggcccagcactggaggaagacaaagatcccgccacgagcaggcacgagacagc tccaggcactcagcgtcccaagagggtcaggacaccattcgtggacacccagggtcaagc agaggaggaaggcagggatcccactatgagcaatcggtagatagttctggacactcaggg tctcatcacagccacaccacgtcccaggaaaggtctgatgtctcccgtgggcagtcagga tccagaagtgtcagcagacaaacacgtaatgagaaacaatcaggagacggctccaggcac tcagggtcgcgtcaccatgaagcttcctctcgggccgacagctctagacactcgcaggtg ggccagggacaatcatcagggcccaggacaagcaggaaccagggatccagtgttagccag gacagtgacagtcagggacactcagaagactctgagaggtggtctgggtctgcttccaga aaccatcttggatctgcttgggagcagtcaagagatggctccagacaccctgggtcccat cacgaagacagagccggtcacgggcactctgcagacagctccagacaatcaggcactcgt cacacagagtcttcctctcgtggacaggctgcgtcatcccatgaacaggcaagatcaagt gcaggagaaagacatggatcccaccaccagctccagtcagcagacagctccagacactca ggcattgggcatggacaagcttcatctgcagtcagagacagtggacaccgagggtacagt ggtagtcaggccagtgacagtgagggacattcagaagactcagacacacagtcagtgtca gcacagggaaaagctgggccccatcagcagagccacaaagagtccgcacgtggccagtca ggggaaagctctggacgttcagggtctttcctctaccaggtgagcactcatgaacagtct gagtccacccatggacagtctgcgcccagcactggaggaagacaaggatcccattatgat caggcacaagacagctccaggcactcagcatcccaagagggtcaggacaccattcgtgga cacccggggccaagcagaggaggaagacaggggtcccaccaagagcaatcggtagatagg tctggacactcagggtctcatcacagccacaccacatcccagggaaggtctgatgcctcc cgtgggcagtcaggatccagaagtgcaagcagaaaaacatatgacaaggaacaatcagga gatggctctaggcactcagggtcgcatcatcatgaagcttcctcttgggccgacagctct agacactcactggtgggccagggacaatcatcagggcccaggacaagcaggccccgggga tccagtgttagccaggacagtgacagtgagggacactcagaagattctgagaggcggtct gggtctgcgtccagaaaccatcatggatctgctcaggagcagtcaagagatggctccaga caccccaggtcccatcacgaagacagagccggtcatgggcactctgcagagagctccaga caatcaggcactcatcatgcagagaattcctctggtggacaggctgcatcatcccatgaa caggcaagatcaagtgcaggagagagacacggatcccaccaccagcagtcagcagacagc tccagacactcaggcattgggcacggacaagcttcatctgcagtcagagacagtggacac cgagggtccagtggtagtcaggccagtgacagtgagggacattcagaagactcagacaca cagtcagtgtcagcccacggacaggctgggccccatcagcagagccaccaagagtccaca cgtggccggtcagcaggaaggtctggacgttcagggtctttcctctaccaggtgagcact catgaacagtctgagtccgcccatggacggaccgggaccagcactggaggaagacaagga tcccaccacaagcaggcacgagacagctccaggcactcaacgtcccaagagggtcaggac accattcatggacacccggggtcaagcagtggaggaaggcagggatcccactacgagcaa ttggtagatagatctggacactcagggtctcatcacagccacaccacatcccagggaagg tctgatgcctcccatgggcactcaggatccagaagtgcaagcagacaaactcgtaacgat gaacaatcaggagacggctccaggcactcagggtcgcgtcaccatgaagcttcctctcgg gccgacagctctggacactcgcaggtgggccagggacaatcagaggggcccaggacaagc aggaactggggatccagttttagccaggacagtgacagtcagggacactcagaagactct gagaggtggtctgggtctgcttccagaaaccatcatggatctgctcaggagcagctaaga gatggctccagacaccccaggtcccatcaagaagacagagctggtcatgggcactctgca gacagctccagacaatcaggcactcgtcacacacagacttcctctggtggacaggctgca tcatcccatgaacaggcaagatcaagtgcaggagaaagacatggatcccaccaccagcag tcagcagacagctccagacactcaggcattgggcacggacaagcttcatctgcagtcaga gacagtggacaccgagggtacagtggtagtcaggccagtgacaatgagggacattcagaa gactcagacacacagtcagtgtcagcccacggacaggctgggtcccatcagcagagccac caagagtccgcacgtggccggtcaggggaaacgtctggacattcaggatctttcctctac caggtgagcactcatgaacagtctgagtcctcccatggatggacggggcccagcactaga ggaagacaaggatcccgccatgagcaggcacaagacagctccaggcactcagcatcccaa gacggtcaggacaccattcgtggacacccggggtcaagcagaggaggaaggcaggggtac caccacgagcattcggtagatagctctggacactcagggtcccatcacagccacaccaca tcccagggaaggtctgatgcctcccgtgggcagtcaggatccagaagtgcaagcagaaca acacgtaatgaggaacaatcaggagacggctccaggcactcagggtcgcgtcaccatgaa gcttccactcatgccgacatctctagacactcacaggcagtccagggacaatcagagggg tccaggagaagcaggcgccagggatccagtgtgagccaggacagtgacagtgagggacat tcagaagactctgagaggtggtctgggtctgcttccagaaaccatcatggatctgctcag gagcagctaagagatggctccagacaccccaggtcccatcaagaagacagagctggtcat gggcactctgcagacagctccagacaatcaggcactcgtcacacacagacttcctctggt ggacaggctgcatcatcccatgaacaggcaagatcaagtgcaggagaaagacatggatcc caccaccagcagtcagcagacagctccagacactcaggcattgggcacggacaagcttca tctgcagtcagagacagtggacaccgagggtacagtggtagtcaggccagtgacaatgag ggacattcagaagactcagacacacagtcagtgtcagcccacggacaggctgggtcccat cagcagagccaccaagagtccgcacgtggccggtcaggggaaacgtctggacattcagga tctttcctctaccaggtgagcactcatgaacagtctgagtcctcccatggatggacgggg cccagcactagaggaagacaaggatcccgccatgagcaggcacaagacagctccaggcac tcagcatcccaatacggtcaggacaccattcgtggacacccggggtcaagcagaggagga aggcaggggtaccaccacgagcattcggtagatagctctggacactcagggtcccatcac agccacaccacatcccagggaaggtctgatgcctcccgtgggcagtcaggatccagaagt gcaagcagaacaacacgtaatgaggaacaatcaggagacagctccaggcactcagtgtca cgtcaccatgaagcttccactcatgccgacatctctagacactcacaggcagtccaggga caatcagaggggtccaggagaagcaggcgccagggatccagtgtgagccaggacagtgac agtgagggacattcagaagactctgagaggtggtctgggtctgcttccagaaaccatcgt ggatctgttcaggagcagtcaaggcacggctccagacaccccaggtcccatcacgaagac agagccggtcacgggcactctgcagaccgctccagacaatcaggcactcgtcacgcagag acttcctctggtggacaggctgcatcatcccatgaacaggcaagatcaagtccaggagag agacacggatcccgccaccagcagtcagcagacagctccagacactcaggcattccgcgt ggacaagcttcatctgcagtcagagacagtagacactgggggtccagtggtagtcaggcc agtgatagtgagggacattcagaagagtcagacacacagtcagtgtcaggccatggacag gctgggccccatcagcagagccaccaagagtccgcacgtgaccggtcagggggaaggtct ggacgttcagggtctttcctctaccaggtgagcactcatgaacagtctgagtctgcccat gggcggaccaggaccagcactggacgaagacaaggatcccaccacgagcaggcacgagac agctccaggcactcagcgtcccaagagggtcaggacaccattcgtggacacccggggtca agcagaagaggaaggcagggatcccactacgagcaatcggtagataggtctggacactca gggtcccatcacagccacaccacatcccagggaaggtctgatgcctcccgtgggcagtca ggatccagaagtgccagcagacaaactcgtaatgacgaacaatcaggagatggctccagg cactcatggtcgcatcaccatgaagcttccactcaggcggacagctctagacactcacag tccggccagggacaatcagcggggcccaggacaagcaggaaccagggatccagtgttagc caggacagtgacagtcagggacactcagaagactctgagaggtggtctgggtctgcttcc agaaaccatcgtggatctgctcaggagcagtcaagagatggctccagacaccccacgtcc catcacgaagacagagccggtcacgggcactctgcagagagctccagacaatcaggcact catcatgcagagaattcctctggtggacaggctgcatcatcccatgaacaggcaagatca agtgcaggagagagacatggatcccaccaccagcagtcagcagacagctccagacactca ggcattgggcacggacaagcttcatctgcagtcagagacagtggacaccgagggtccagt ggtagtcaggccagtgacagtgagggacattcagaagactcagacacacagtcagtgtca gcccacggacaggctgggccccatcagcagagccaccaagagtccacacgtggccggtca gcaggaaggtctggacgttcagggtctttcctctaccaggtgagcactcatgaacagtct gagtctgcccatggacgggctgggcccagtactggaggaagacaaggatcccgccacgag caggcacgagacagctccaggcactcagcgtcccaagagggtcaggacaccattcgtgga cacccggggtcaaggagaggaggaagacagggatcctaccacgagcaatcggtagatagg tctggacactcagggtcccatcacagccacaccacatcccagggaaggtctgatgcctcc catgggcagtcaggatccagaagtgcaagcagagaaacacgtaatgaggaacagtcagga gacggctccaggcactcagggtcgcgtcaccatgaagcttccactcaggctgacagctct agacactcacagtccggccagggtgaatcagcggggtccaggagaagcaggcgccaggga tccagtgttagccaggacagtgacagtgaggcatacccagaggactctgagaggcgatct gagtctgcttccagaaaccatcatggatcttctcgggagcagtcaagagatggctccaga caccccggatcctctcaccgcgatacagccagtcatgtacagtcttcacctgtacagtca gactctagtaccgctaaggaacatggtcactttagtagtctttcacaagattctgcgtat cactcaggaatacagtcacgtggcagtcctcacagttctagttcttatcattatcaatct gagggcactgaaaggcaaaaaggtcaatcaggtttagtttggagacatggcagctatggt agtgcagattatgattatggtgaatccgggtttagacactctcagcacggaagtgttagt tacaattccaatcctgttgttttcaaggaaagatctgatatctgtaaagcaagtgcgttt ggtaaagatcatccaaggtattatgcaacgtatattaataaggacccaggtttatgtggc cattctagtgatatatcgaaacaactgggatttagtcagtcacagagatactattactat gagtaa

Homo sapiens (human): 388698 Help Entry 388698            CDS       T01001                                  Symbol FLG2, IFPS, PSS6 Name (RefSeq) filaggrin-2   KO K10384   filaggrin Organism hsa  Homo sapiens (human) Pathway hsa04382   Cornified envelope formation Network nt06545  Cornified envelope formation   Element N01930   Processing of profilaggrin to filaggrin and binding to keratin filaments N01931   Processing of filaggrin to amino acids Disease H00737   Peeling skin syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09158 Development and regeneration    04382 Cornified envelope formation     388698 (FLG2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     388698 (FLG2) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Intermediate filaments    Intermediate filament-binding proteins     388698 (FLG2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  S_100 EF-hand_7 EF-hand_1 EF-hand_FSTL1 Motif Other DBs NCBI-GeneID:  388698 NCBI-ProteinID:  NP_001014364 OMIM:  616284 HGNC:  33276 Ensembl:  ENSP00000373370.4 UniProt:  Q5D862 LinkDB All DBs Position 1:complement(152348735..152360006) Genome browser AA seq 2391 aa AA seqDB search MTDLLRSVVTVIDVFYKYTKQDGECGTLSKGELKELLEKELHPVLKNPDDPDTVDVIMHM LDRDHDRRLDFTEFLLMIFKLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEE DTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKR YHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGL SCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSSGCGRPQNASSSCQS HRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGAREN GQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYG SGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFG QHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQ SSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGS GQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGS GSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFG QHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQS SGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRS HQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQH GTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSG FGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSG QTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHG SGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSG FAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSG QSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQT GSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGD TTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGES ESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRP QSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSG HSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQ TTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTT HGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQ HGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGV SHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRS SGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQS GHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQ TTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAG SHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHS GVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGR RGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQS GHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQG TTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAG SQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGS SQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWSTDSTANKQLSRH NT seq 7176 nt NT seq  +upstreamnt  +downstreamnt atgaccgacctcttgagaagtgttgtcaccgtaattgatgttttctacaaatacaccaag caagatggggagtgtggcacactgagcaagggtgaactaaaggaacttctggagaaagag cttcatccagttctgaagaacccagatgatccagacacagtggatgtcatcatgcatatg ctggatcgagatcatgacagaagattggactttactgagtttcttttgatgatattcaag ctgactatggcctgcaacaaggtcctcagcaaagaatactgcaaagcttcagggtcaaag aagcataggcgtggtcaccgacaccaagaagaagaaagtgaaacagaagaggatgaagag gatacaccaggacataaatcaggttacagacattcaagttggagtgagggagaggagcat ggatatagttctgggcactcaaggggaactgtgaaatgtagacatgggtccaactccagg aggctaggaagacaaggtaatttatccagctctgggaaccaagagggatctcagaaaaga taccacaggtccagctgtggtcattcatggagtggtggcaaagacagacatggttccagc tctgtagaactgagagaaagaataaacaagtcacacattagcccttctagggaatctggg gaggagtatgaatctggatctggatcaaacagttgggaaaggaaaggtcatggtggtctg tcatgtggattggagactagtgggcatgaatcaaactctactcagtcaagaattagagaa caaaagcttgggtctagctgttcaggttcaggagacagtgggaggcgaagtcatgcatgt ggttatagcaattcaagtgggtgtggaaggccacaaaatgcttcaagttcttgtcagtca catagatttggagggcaaggaaatcaatttagctatattcagtcaggctgtcagtcagga attaagggaggacaaggccatggctgtgtctcaggaggtcagccctctggatgtggtcaa cctgagtctaacccctgtagtcagtcctatagtcagagaggatatggagctagagaaaat ggtcaaccacagaactgtggaggacaatggagaacaggctcaagtcagtcctcttgctgt ggacaatatgggtctggaggtagccagtcttgtagtaatggtcaacatgaatatggttcc tgtggccgcttttcaaactcttctagttcaaatgaattttccaaatgtgatcaatatggg tctggttcaagtcagtctactagctttgaacaacatggaacaggcttgagtcagtcctct gggttcgaacaacatgtatgtggctcaggtcaaacttgtggccagcatgagtctacatca agtcaatccttgggctatgaccagcatgggtctagctcaggtaagacatctggctttgga caacatgggtctggctcaggtcagtcctctggctttggacaatgtgggtcaggctcaggt cagtcctctggctttggacagcatgggtctgtctcaggacaatcctctggttttggacag catgggtctgtctcaggacaatcctctggttttggacaacatgagtctagatcacgtcag tctagctatggccaacatggttctggctcaagtcaatcatctggctatggccaatatggg tctagagagacatctggctttggacaacatgggttgggctcaggtcaatccactggcttt ggccaatatggatcgggctcaggtcagtcctctggctttggacaacatgggtctggctca ggacaatcctctggctttggacaacatgagtctagatcaggtcagtctagttatggccaa cacagttctggctcaagtcagtcatctggctatggccaacatgggtctagacagacatct ggctttggacaacatgggtcaggctcaagtcaatccactggctttggccaatatggatca ggctcaggtcagtcctctggctttggacaacatgtttctggctcaggacaatcctctggt tttggacaacatgagtctagatcaggtcattctagctatggccaacatggttttggctca agtcaatcatctggctatggtcaacatgggtcaagttcaggacagacatctggatttgga caacacgagttaagctcaggtcagtcttccagctttggccaacatggatcaggctcaggt cagtcctctggctttggacaacatgggtctggctcaggacaatcctctggctttggacaa catgagtctagatcaggtcagtctagctatggccaacacagttctggctcaagtcagtca tctggctatggccaacatgggtctagacagacatctggctttggacaacatgggtcaggc tcaagtcaatccactggctttggccaatatggatcaggctcaggtcagtccgctggcttt ggacaacatgggtctggctcaggacaatcctctggctttggacagcatgagtctagatca catcagtccagctatggccaacatggttctggctcaagtcaatcatctggctatggtcaa catgggtcaagttcgggacagacatctggctttggacaacacaggtcaagctcaggtcaa tactctggctttggacaacatggatcaggctcaggtcagtccagtggctttggacaacat gggactggctcaggacaatactctggttttggacaacatgagtctagatcacatcagtct agctatggccaacatggttctggctcaagtcagtcatctggctatggtcaacatgggtca agttcaggacagacttttggatttggacaacacaggtcaggctcaggtcaatcctctggc tttggccaacatggatcaggctcaggtcagtcctctggctttggacaacatgagtcaggc tcaggaaaatcctctggctttggacagcatgagtctagatcaagtcagtctaattatggc caacatggttctggctcaagtcagtcatctggctatggtcaacatgggtctagttcagga cagacaactggctttggacaacacaggtcaagctcaggccaatactcaggctttggacaa catggatcaggctcagatcagtcctctggctttggacaacatgggactggttcaggacaa tcctctggttttggacaatatgagtctagatcacgtcagtctagctatggccaacatggt tctggctcaagtcaatcatctggctatggtcaacatgggtcaaattcaggacagacatct ggatttggacaacacaggccaggctcaggtcagtcctctggctttggccaatatggatcg ggctcaggtcagtcttctggctttggacaacatgggtcaggcacaggtaaatcctctggc tttgcacagcatgagtacagatcaggtcagtctagctatggccaacatggtactggctcc agtcaatcatctggctgtggccaacatgagtctggctcaggtccaaccacaagttttgga cagcatgtgtctggctcagacaatttctctagttctggacaacatatatctgactcaggt cagtccactggatttggccaatatggttcaggctcaggtcaatcaactggcttgggccag ggtgaatctcaacaagtagagtcaggatccacagttcatgggagacaggaaactactcat ggtcagacaataaataccactagacatagccagtctggtcaaggacaatccacacagaca gggtccagggtaactagaagacgaagatctagccaaagtgagaacagtgacagtgaagtg cactcaaaggtctcacacagacattcagaacacattcacacacaagctggatctcactac ccaaagtcaggatccacagttcgcagaagacaaggaactactcatggacagagaggagat accactagacatggccattctggtcatggacagtctacacagacaggttccagaacatct ggaagacagagatttagccacagtgatgccactgacagtgaagtgcactcaggggtctca catagaccacactcacaagaacaaactcacagccaagctggatctcaacatggagagtca gaatccacagttcatgagagacatgaaactacttatggacagacaggagaggccactgga catggccactctggtcatggacagtccacacagagagggtccaggacaactggaagaagg ggatctggccatagtgagtccagtgacagtgaagtgcactcagggggctcacacagacca caatcacaagaacaaactcatggccaagccggatctcaacatggagagtcaggatccaca gttcatgggagacacggaactactcatggacagacaggagataccactagacatgcccac tatcatcatggaaaatccacacagagagggtccagtacaactggaagaaggggatctggc cacagtgagtccagtgacagtgaagtgcactcagggggctcgcacacacattcaggacac actcacggccaaagtggatctcaacatggagagtcagaatccataattcatgacagacac agaattactcatggacagacaggagataccactagacattcctactctggtcatgaacaa accacacagacagggtccaggacaactggaagacagagaactagccacagtgagtccact gacagtgaagtgcactcagggggctcacacagaccacactcacgagaacacacttacggc caagccggatctcaacatgaagagccagaattcacagttcatgagagacacggaactact catggacagataggagataccactggacattcccactctggtcatggacagtccacacag agagggtccaggacaactggaagacagagatctagccacagtgagtccagtgacagtgaa gtgcactcaggggtctcacacacacatacaggacacactcatggtcaagctggatctcaa catggacagtcagaatccatagttcctgagagacatggaactactcatggacagacagga gataccactagacatgcccactatcatcatggattaaccacacagacagggtccaggact actggaagaaggggatctggccacagtgagtacagtgacagtgaagggtactcaggagtc tcacatacacattcaggacacactcatggccaagccagatctcaacatggagagtcagaa tccatagttcatgagagacatggaactatacatggacagacaggcgataccaccagacat gcccactctggtcatggacagtccacacagacagggtccaggaccactggaagaaggtca tctggccacagtgagtacagtgacagtgaagggcactcagggttctcacaaagaccacac tcacgaggacacactcacggccaggctggatctcaacatggagagtcagaatccatagtt gacgagagacatggaactactcatggacagacaggagataccagtggacattctcaatct ggtcatggacagtccacacagtcaggatccagtacaactggaagaaggagatctggccac agtgagtccagtgacagtgaagtgcactcagggggctcacatacacattcaggacacaca cacagccaagccaggtctcaacatggagagtcagaatccacagttcacaagagacaccaa actactcatggacagacaggagataccactgaacatggccaccctagtcatggacaaacc atacagacagggtccaggacaactggaagaaggggatctggccacagtgagtacagtgac agtgaagggccctcaggggtctcacacacacattcaggacacactcacggtcaagctgga tctcactatccagagtcaggatcctcagttcatgagagacacggaactactcatggacaa acagcagataccactagacatggccactctggtcatggacagtccacacagagagggtcc aggacaactggaagaagggcatctggccacagtgagtacagtgacagtgaagggcactca ggggtctcacacacacattcaggacacgctcatggccaagccggatctcaacatggagag tcaggatcctcagttcatgagagacacggaactactcatggacagacaggagataccact agacatgctcactctggtcatggacagtccacacagagagggtcaaggacagctggaaga aggggatctggccacagtgagtccagtgacagtgaagtgcactcaggggtctcacacaca cattcaggacacacttatggccaagccagatctcaacatggagagtcaggatctgccatt cacgggagacagggaactatacatggacagacaggagataccactagacatggccagtct ggtcatggacagtccacacagacaggttccaggacaactggaagacaaagatctagtcac agtgagtccagtgatagtgaagtgcactcagaggcctcacccacacattcaggacacact cacagccaagccggatctcgacatggacagtcaggatcctcaggtcatgggagacaggga actactcatggacagacaggagataccactagacatgcccactatggttatggacaatcc acacagagagggtccaggacaactggaagaaggggatctggccacagtgagtccagtgac agtgaagtgcactcatggggctcacacacacattcaggacacattcagggccaagctgga tctcaacaaagacagccaggatccacagttcatgggagactggaaactactcatggacag acaggagataccactagacatggccattctggttatggacaatccacacagacaggttcc agatctagtagagcaagtcattttcagtcacatagtagtgaaaggcaaaggcatggatca agtcaggtttggaaacatggcagctatggacctgcagaatatgactatgggcacactggg tatgggccttctggtggcagcagaaaaagcatcagtaattctcacctttcatggtcaaca gacagcactgcaaacaagcaactgtctagacattga

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