KEGG   Homo sapiens (human): 2693
Entry
2693              CDS       T01001                                 
Symbol
GHSR, GHDP, GHS-R1a, GHSR-1a
Name
(RefSeq) growth hormone secretagogue receptor
  KO
K04284  growth hormone secretagogue receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04935  Growth hormone synthesis, secretion and action
Network
nt06324  GHRH-GH-IGF signaling
  Element
N01782  GHRL-GHSR signaling
Disease
H00254  Growth hormone deficiency
Drug target
Anamorelin hydrochloride: D08856<JP>
Capromorelin tartrate: D03373
Macimorelin (DG01879): D10562<US> D10563
Pralmorelin dihydrochloride: D02040<JP>
Relamorelin: D10660
Rismorelin porcine: D05734
Ulimorelin (DG01338): D09981 D09982
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2693 (GHSR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2693 (GHSR)
   04081 Hormone signaling
    2693 (GHSR)
 09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    2693 (GHSR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2693 (GHSR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Ghrelin
    2693 (GHSR)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srw 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx 7tm_4
Other DBs
NCBI-GeneID: 2693
NCBI-ProteinID: NP_940799
OMIM: 601898
HGNC: 4267
Ensembl: ENSG00000121853
UniProt: Q92847
Structure
LinkDB
Position
3:complement(172443291..172448456)
AA seq 366 aa
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
NT seq 1101 nt   +upstreamnt  +downstreamnt
atgtggaacgcgacgcccagcgaagagccggggttcaacctcacactggccgacctggac
tgggatgcttcccccggcaacgactcgctgggcgacgagctgctgcagctcttccccgcg
ccgctgctggcgggcgtcacagccacctgcgtggcactcttcgtggtgggcatcgctggc
aacctgctcaccatgctggtggtgtcgcgcttccgcgagctgcgcaccaccaccaacctc
tacctgtccagcatggccttctccgatctgctcatcttcctctgcatgcccctggacctc
gttcgcctctggcagtaccggccctggaacttcggcgacctcctctgcaaactcttccaa
ttcgtcagtgagagctgcacctacgccacggtgctcaccatcacagcgctgagcgtcgag
cgctacttcgccatctgcttcccactccgggccaaggtggtggtcaccaaggggcgggtg
aagctggtcatcttcgtcatctgggccgtggccttctgcagcgccgggcccatcttcgtg
ctagtcggggtggagcacgagaacggcaccgacccttgggacaccaacgagtgccgcccc
accgagtttgcggtgcgctctggactgctcacggtcatggtgtgggtgtccagcatcttc
ttcttccttcctgtcttctgtctcacggtcctctacagtctcatcggcaggaagctgtgg
cggaggaggcgcggcgatgctgtcgtgggtgcctcgctcagggaccagaaccacaagcaa
accgtgaaaatgctggctgtagtggtgtttgccttcatcctctgctggctccccttccac
gtagggcgatatttattttccaaatcctttgagcctggctccttggagattgctcagatc
agccagtactgcaacctcgtgtcctttgtcctcttctacctcagtgctgccatcaacccc
attctgtacaacatcatgtccaagaagtaccgggtggcagtgttcagacttctgggattc
gaacccttctcccagagaaagctctccactctgaaagatgaaagttctcgggcctggaca
gaatctagtattaatacatga

KEGG   Homo sapiens (human): 112609
Entry
112609            CDS       T01001                                 
Symbol
MRAP2, C6orf117, bA51G5.2
Name
(RefSeq) melanocortin 2 receptor accessory protein 2
  KO
K25968  melanocortin-2 receptor accessory protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04935  Growth hormone synthesis, secretion and action
Network
nt06324  GHRH-GH-IGF signaling
  Element
N01782  GHRL-GHSR signaling
Disease
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    112609 (MRAP2)
SSDB
Motif
Pfam: MRAP
Other DBs
NCBI-GeneID: 112609
NCBI-ProteinID: NP_001333471
OMIM: 615410
HGNC: 21232
Ensembl: ENSG00000135324
UniProt: Q96G30
LinkDB
Position
6:84033178..84146282
AA seq 205 aa
MSAQRLISNRTSQQSASNSDYTWEYEYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFM
FFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHCYI
NEVERLDRAKACHQTTALDSDVQLQEAIRSSGQPEEELNRLMKFDIPNFVNTDQNYFGED
DLLISEPPIVLETKPLSQTSHKDLD
NT seq 618 nt   +upstreamnt  +downstreamnt
atgtccgcccagaggttaatttctaacagaacctcccagcaatcggcatctaattctgat
tacacctgggaatatgaatattatgagattggaccagtttcctttgaaggactgaaggct
cataaatattccattgtgattggattttgggttggtcttgcagtcttcgtgatttttatg
ttttttgtgctgaccttgctgaccaagacaggagccccacaccaagacaatgcagagtcc
tcagagaagagattcagaatgaacagctttgtgtcagactttggaagacctctggagcca
gataaagtattttctcgccaaggcaacgaggagtccaggtctctctttcactgctacatc
aatgaggtggaacgcttggacagagccaaagcttgtcaccagaccacagcccttgacagt
gacgtccaactccaggaagccatcagaagcagtgggcagccagaggaggagctgaacagg
ctcatgaagtttgacatccccaactttgtgaacacagaccagaactactttggggaggat
gatcttctgatttctgaaccacctattgttctggaaactaagccactttcccagacctca
cacaaagacctggattga

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