KEGG   Homo sapiens (human): 2729
Entry
2729              CDS       T01001                                 
Symbol
GCLC, GCL, GCS, GLCL, GLCLC
Name
(RefSeq) glutamate-cysteine ligase catalytic subunit
  KO
K11204  glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04216  Ferroptosis
Module
hsa_M00118  Glutathione biosynthesis, glutamate => glutathione
Network
nt06026  Glutathione biosynthesis
nt06525  Ferroptosis
  Element
N01589  Glutathione biosynthesis
Disease
H00668  Anemia due to disorders of glutathione metabolism
H01730  Myocardial infarction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    2729 (GCLC)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2729 (GCLC)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    2729 (GCLC)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.2  glutamate---cysteine ligase
     2729 (GCLC)
SSDB
Motif
Pfam: GCS GCS2
Other DBs
NCBI-GeneID: 2729
NCBI-ProteinID: NP_001489
OMIM: 606857
HGNC: 4311
Ensembl: ENSG00000001084
UniProt: P48506 Q14TF0
LinkDB
Position
6:complement(53497341..53545101)
AA seq 637 aa
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
NT seq 1914 nt   +upstreamnt  +downstreamnt
atggggctgctgtcccagggctcgccgctgagctgggaggaaaccaagcgccatgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgttctcaagtggggcgatgaggtggaatacatgttggtatcttttgatcat
gaaaataaaaaagtccggttggtcctgtctggggagaaagttcttgaaactctgcaagag
aagggggaaaggacaaacccaaaccatcctaccctttggagaccagagtatgggagttac
atgattgaagggacaccaggacagccctacggaggaacaatgtccgagttcaatacagtt
gaggccaacatgcgaaaacgccggaaggaggctacttctatattagaagaaaatcaggct
ctttgcacaataacttcatttcccagattaggctgtcctgggttcacactgcccgaggtc
aaacccaacccagtggaaggaggagcttccaagtccctcttctttccagatgaagcaata
aacaagcaccctcgcttcagtaccttaacaagaaatatccgacataggagaggagaaaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccatctccatttatagaaaca
tttactgaggatgatgaagcttcaagggcttctaagccggatcatatttacatggatgcc
atgggatttggaatgggcaattgctgtctccaggtgacattccaagcctgcagtatatct
gaggccagatacctttatgatcagttggctactatctgtccaattgttatggctttgagt
gctgcatctcccttttaccgaggctatgtgtcagacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaactcgggaggagcgaggactggagccattgaagaacaat
aactataggatcagtaaatcccgatatgactcaatagacagctatttatctaagtgtggt
gagaaatataatgacatcgacttgacgatagataaagagatctacgaacagctgttgcag
gaaggcattgatcatctcctggcccagcatgttgctcatctctttattagagacccactg
acactgtttgaagagaaaatacacctggatgatgctaatgagtctgaccattttgagaat
attcagtccacaaattggcagacaatgagatttaagccccctcctccaaactcagacatt
ggatggagagtagaatttcgacccatggaggtgcaattaacagactttgagaactctgcc
tatgtggtgtttgtggtactgctcaccagagtgatcctttcctacaaattggattttctc
attccactgtcaaaggttgatgagaacatgaaggtagcacagaaaagagatgctgtcttg
cagggaatgttttatttcaggaaagatatttgcaaaggtggcaatgcagtggtggatggt
tgtggcaaggcccagaacagcacggagctcgctgcagaggagtacaccctcatgagcata
gacaccatcatcaatgggaaggaaggtgtgtttcctggactgatcccaattctgaactct
taccttgaaaacatggaagtggatgtggacaccagatgtagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgacagttgccagatggatgagggagttt
atcgcaaaccatcctgactacaagcaagacagtgtcataactgatgaaatgaattatagc
cttattttgaagtgtaaccaaattgcaaatgaattatgtgaatgcccagagttacttgga
tcagcatttaggaaagtaaaatatagtggaagtaaaactgactcatccaactag

KEGG   Homo sapiens (human): 2730
Entry
2730              CDS       T01001                                 
Symbol
GCLM, GLCLR
Name
(RefSeq) glutamate-cysteine ligase modifier subunit
  KO
K11205  glutamate--cysteine ligase regulatory subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04216  Ferroptosis
Module
hsa_M00118  Glutathione biosynthesis, glutamate => glutathione
Network
nt06026  Glutathione biosynthesis
nt06525  Ferroptosis
  Element
N01589  Glutathione biosynthesis
Disease
H01730  Myocardial infarction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    2730 (GCLM)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2730 (GCLM)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    2730 (GCLM)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 2730
NCBI-ProteinID: NP_002052
OMIM: 601176
HGNC: 4312
Ensembl: ENSG00000023909
UniProt: P48507
LinkDB
Position
1:complement(93885199..93909430)
AA seq 274 aa
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP
DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA
QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ
VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH
EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
NT seq 825 nt   +upstreamnt  +downstreamnt
atgggcaccgacagccgcgcggccaaggcgctcctggcgcgggcccgcaccctgcacctg
cagacggggaacctgctgaactggggccgcctgcggaagaagtgcccgtccacgcacagc
gaggagcttcatgattgtatccaaaaaaccttgaatgaatggagttcccaaatcaaccca
gatttggtcagggagtttccagatgtcttggaatgcactgtatctcatgcagtagaaaag
ataaatcctgatgaaagagaagaaatgaaagtttctgcaaaactgttcattgtagaatca
aactcttcatcatcaactagaagtgcagttgacatggcctgttcagtccttggagttgca
cagctggattctgtgatcattgcttcacctcctattgaagatggagttaatctttccttg
gagcatttacagccttactgggaggaattagaaaacttagttcagagcaaaaagattgtt
gccataggtacctctgatctagacaaaacacagttggaacagctgtatcagtgggcacag
gtaaaaccaaatagtaaccaagttaatcttgcctcctgctgtgtgatgccaccagatttg
actgcatttgctaaacaatttgacatacagctgttgactcacaatgatccaaaagaactg
ctttctgaagcaagtttccaagaagctcttcaggaaagcattcctgacattcaagcgcac
gagtgggtgccgctgtggctactgcggtattcggtcattgtgaaaagtagaggaattatc
aaatcaaaaggctacattttacaagctaaaagaaggggttcttaa

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