| Entry |
|
|---|
| Name |
|
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| Definition |
Cys+Glu -- (GCLC+GCLM) >> GSS -> GSH -- GPX -> GSSG |
|---|
| Expanded |
(C00097+C00025) -- (2729+2730) >> 2937 -> C00051 -- (2876,2877,2878,2879,2880,257202,2882,493869) -> C00127 |
|---|
| Class |
|
|---|
| Type |
Reference
|
|---|
| Pathway |
|
|---|
| Gene |
| 2729 | GCLC; glutamate-cysteine ligase catalytic subunit |
| 2730 | GCLM; glutamate-cysteine ligase modifier subunit |
| 2937 | GSS; glutathione synthetase |
| 2876 | GPX1; glutathione peroxidase 1 |
| 2877 | GPX2; glutathione peroxidase 2 |
| 2878 | GPX3; glutathione peroxidase 3 |
| 2879 | GPX4; glutathione peroxidase 4 |
| 2880 | GPX5; glutathione peroxidase 5 |
| 257202 | GPX6; glutathione peroxidase 6 |
| 2882 | GPX7; glutathione peroxidase 7 |
| 493869 | GPX8; glutathione peroxidase 8 (putative) |
|
|---|
| Metabolite |
|
|---|
| Reference |
|
|---|
| Authors |
Chen X, Li J, Kang R, Klionsky DJ, Tang D |
|---|
| Title |
Ferroptosis: machinery and regulation. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Fang X, Ardehali H, Min J, Wang F |
|---|
| Title |
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM |
|---|
| Title |
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. |
|---|
| Journal |
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|---|
| LinkDB |
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