Homo sapiens (human): 2730
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Entry
2730 CDS
T01001
Symbol
GCLM, GLCLR
Name
(RefSeq) glutamate-cysteine ligase modifier subunit
KO
K11205
glutamate--cysteine ligase regulatory subunit
Organism
hsa
Homo sapiens (human)
Pathway
hsa00270
Cysteine and methionine metabolism
hsa00480
Glutathione metabolism
hsa01100
Metabolic pathways
hsa01240
Biosynthesis of cofactors
hsa04216
Ferroptosis
Module
hsa_M00118
Glutathione biosynthesis, glutamate => glutathione
Network
nt06026
Glutathione biosynthesis
nt06525
Ferroptosis
Element
N01589
Glutathione biosynthesis
Disease
H01730
Myocardial infarction
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
2730 (GCLM)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
2730 (GCLM)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
2730 (GCLM)
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Gene cluster
GFIT
Motif
Pfam:
Aldo_ket_red
Motif
Other DBs
NCBI-GeneID:
2730
NCBI-ProteinID:
NP_002052
OMIM:
601176
HGNC:
4312
Ensembl:
ENSG00000023909
UniProt:
P48507
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Position
1:complement(93885199..93909430)
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AA seq
274 aa
AA seq
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MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP
DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA
QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ
VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH
EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
NT seq
825 nt
NT seq
+upstream
nt +downstream
nt
atgggcaccgacagccgcgcggccaaggcgctcctggcgcgggcccgcaccctgcacctg
cagacggggaacctgctgaactggggccgcctgcggaagaagtgcccgtccacgcacagc
gaggagcttcatgattgtatccaaaaaaccttgaatgaatggagttcccaaatcaaccca
gatttggtcagggagtttccagatgtcttggaatgcactgtatctcatgcagtagaaaag
ataaatcctgatgaaagagaagaaatgaaagtttctgcaaaactgttcattgtagaatca
aactcttcatcatcaactagaagtgcagttgacatggcctgttcagtccttggagttgca
cagctggattctgtgatcattgcttcacctcctattgaagatggagttaatctttccttg
gagcatttacagccttactgggaggaattagaaaacttagttcagagcaaaaagattgtt
gccataggtacctctgatctagacaaaacacagttggaacagctgtatcagtgggcacag
gtaaaaccaaatagtaaccaagttaatcttgcctcctgctgtgtgatgccaccagatttg
actgcatttgctaaacaatttgacatacagctgttgactcacaatgatccaaaagaactg
ctttctgaagcaagtttccaagaagctcttcaggaaagcattcctgacattcaagcgcac
gagtgggtgccgctgtggctactgcggtattcggtcattgtgaaaagtagaggaattatc
aaatcaaaaggctacattttacaagctaaaagaaggggttcttaa
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