Homo sapiens (human): 284 Help Entry 284               CDS       T01001                                  Symbol ANGPT1, AGP1, AGPT, AGPT-1, ANG1, HAE5 Name (RefSeq) angiopoietin 1   KO K05465   angiopoietin 1 Organism hsa  Homo sapiens (human) Pathway hsa04010   MAPK signaling pathway hsa04014   Ras signaling pathway hsa04015   Rap1 signaling pathway hsa04066   HIF-1 signaling pathway hsa04151   PI3K-Akt signaling pathway hsa05323   Rheumatoid arthritis Network nt06526  MAPK signaling nt06530  PI3K signaling   Element N01592   GF-RTK-RAS-ERK signaling pathway N01656   GF-RTK-PI3K signaling pathway N01658   GF-RTK-RAS-PI3K signaling pathway Disease H01006   Hereditary angioedema Drug target Trebananib:  D10177 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     284 (ANGPT1)    04014 Ras signaling pathway     284 (ANGPT1)    04015 Rap1 signaling pathway     284 (ANGPT1)    04066 HIF-1 signaling pathway     284 (ANGPT1)    04151 PI3K-Akt signaling pathway     284 (ANGPT1)  09160 Human Diseases   09163 Immune disease    05323 Rheumatoid arthritis     284 (ANGPT1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:hsa04052]     284 (ANGPT1) Cytokines and neuropeptides [BR:hsa04052]  Cytokines   Growth factors (RTK binding)    284 (ANGPT1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Fibrinogen_C Motif Other DBs NCBI-GeneID:  284 NCBI-ProteinID:  NP_001137 OMIM:  601667 HGNC:  484 Ensembl:  ENSG00000154188 Pharos:  Q15389(Tbio) UniProt:  Q15389 Structure PDB LinkDB All DBs Position 8:complement(107249482..107497918) Genome browser AA seq 498 aa AA seqDB search MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTD QYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAV QNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQ TNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRA TTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIY TIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNE FIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLIL HGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFK GPSYSLRSTTMMIRPLDF NT seq 1497 nt NT seq  +upstreamnt  +downstreamnt atgacagttttcctttcctttgctttcctcgctgccattctgactcacatagggtgcagc aatcagcgccgaagtccagaaaacagtgggagaagatataaccggattcaacatgggcaa tgtgcctacactttcattcttccagaacacgatggcaactgtcgtgagagtacgacagac cagtacaacacaaacgctctgcagagagatgctccacacgtggaaccggatttctcttcc cagaaacttcaacatctggaacatgtgatggaaaattatactcagtggctgcaaaaactt gagaattacattgtggaaaacatgaagtcggagatggcccagatacagcagaatgcagtt cagaaccacacggctaccatgctggagataggaaccagcctcctctctcagactgcagag cagaccagaaagctgacagatgttgagacccaggtactaaatcaaacttctcgacttgag atacagctgctggagaattcattatccacctacaagctagagaagcaacttcttcaacag acaaatgaaatcttgaagatccatgaaaaaaacagtttattagaacataaaatcttagaa atggaaggaaaacacaaggaagagttggacaccttaaaggaagagaaagagaaccttcaa ggcttggttactcgtcaaacatatataatccaggagctggaaaagcaattaaacagagct accaccaacaacagtgtccttcagaagcagcaactggagctgatggacacagtccacaac cttgtcaatctttgcactaaagaaggtgttttactaaagggaggaaaaagagaggaagag aaaccatttagagactgtgcagatgtatatcaagctggttttaataaaagtggaatctac actatttatattaataatatgccagaacccaaaaaggtgttttgcaatatggatgtcaat gggggaggttggactgtaatacaacatcgtgaagatggaagtctagatttccaaagaggc tggaaggaatataaaatgggttttggaaatccctccggtgaatattggctggggaatgag tttatttttgccattaccagtcagaggcagtacatgctaagaattgagttaatggactgg gaagggaaccgagcctattcacagtatgacagattccacataggaaatgaaaagcaaaac tataggttgtatttaaaaggtcacactgggacagcaggaaaacagagcagcctgatctta cacggtgctgatttcagcactaaagatgctgataatgacaactgtatgtgcaaatgtgcc ctcatgttaacaggaggatggtggtttgatgcttgtggcccctccaatctaaatggaatg ttctatactgcgggacaaaaccatggaaaactgaatgggataaagtggcactacttcaaa gggcccagttactccttacgttccacaactatgatgattcgacctttagatttttga

Homo sapiens (human): 285 Help Entry 285               CDS       T01001                                  Symbol ANGPT2, AGPT2, ANG2, LMPHM10 Name (RefSeq) angiopoietin 2   KO K05466   angiopoietin 2 Organism hsa  Homo sapiens (human) Pathway hsa04010   MAPK signaling pathway hsa04014   Ras signaling pathway hsa04015   Rap1 signaling pathway hsa04066   HIF-1 signaling pathway hsa04151   PI3K-Akt signaling pathway hsa05167   Kaposi sarcoma-associated herpesvirus infection Network nt06526  MAPK signaling nt06530  PI3K signaling   Element N01592   GF-RTK-RAS-ERK signaling pathway N01656   GF-RTK-PI3K signaling pathway N01658   GF-RTK-RAS-PI3K signaling pathway Disease H00535   Lymphatic malformation Drug target Faricimab:  D11516<JP/US> Nesvacumab:  D10395 Trebananib:  D10177 Vanucizumab:  D11244 Zansecimab:  D11904 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     285 (ANGPT2)    04014 Ras signaling pathway     285 (ANGPT2)    04015 Rap1 signaling pathway     285 (ANGPT2)    04066 HIF-1 signaling pathway     285 (ANGPT2)    04151 PI3K-Akt signaling pathway     285 (ANGPT2)  09160 Human Diseases   09172 Infectious disease: viral    05167 Kaposi sarcoma-associated herpesvirus infection     285 (ANGPT2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:hsa04052]     285 (ANGPT2) Cytokines and neuropeptides [BR:hsa04052]  Cytokines   Growth factors (RTK binding)    285 (ANGPT2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Fibrinogen_C Motif Other DBs NCBI-GeneID:  285 NCBI-ProteinID:  NP_001138 OMIM:  601922 HGNC:  485 Ensembl:  ENSG00000091879 Pharos:  O15123(Tbio) UniProt:  O15123 Structure PDB LinkDB All DBs Position 8:complement(6499632..6563245) Genome browser AA seq 496 aa AA seqDB search MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPY VSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQ TAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSE INKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVN NSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTL TFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFV SQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPG NDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGS GYSLKATTMMIRPADF NT seq 1491 nt NT seq  +upstreamnt  +downstreamnt atgtggcagattgttttctttactctgagctgtgatcttgtcttggccgcagcctataac aactttcggaagagcatggacagcataggaaagaagcaatatcaggtccagcatgggtcc tgcagctacactttcctcctgccagagatggacaactgccgctcttcctccagcccctac gtgtccaatgctgtgcagagggacgcgccgctcgaatacgatgactcggtgcagaggctg caagtgctggagaacatcatggaaaacaacactcagtggctaatgaagcttgagaattat atccaggacaacatgaagaaagaaatggtagagatacagcagaatgcagtacagaaccag acggctgtgatgatagaaatagggacaaacctgttgaaccaaacagcggagcaaacgcgg aagttaactgatgtggaagcccaagtattaaatcagaccacgagacttgaacttcagctc ttggaacactccctctcgacaaacaaattggaaaaacagattttggaccagaccagtgaa ataaacaaattgcaagataagaacagtttcctagaaaagaaggtgctagctatggaagac aagcacatcatccaactacagtcaataaaagaagagaaagatcagctacaggtgttagta tccaagcaaaattccatcattgaagaactagaaaaaaaaatagtgactgccacggtgaat aattcagttcttcagaagcagcaacatgatctcatggagacagttaataacttactgact atgatgtccacatcaaactcagctaaggaccccactgttgctaaagaagaacaaatcagc ttcagagactgtgctgaagtattcaaatcaggacacaccacgaatggcatctacacgtta acattccctaattctacagaagagatcaaggcctactgtgacatggaagctggaggaggc gggtggacaattattcagcgacgtgaggatggcagcgttgattttcagaggacttggaaa gaatataaagtgggatttggtaacccttcaggagaatattggctgggaaatgagtttgtt tcgcaactgactaatcagcaacgctatgtgcttaaaatacaccttaaagactgggaaggg aatgaggcttactcattgtatgaacatttctatctctcaagtgaagaactcaattatagg attcaccttaaaggacttacagggacagccggcaaaataagcagcatcagccaaccagga aatgattttagcacaaaggatggagacaacgacaaatgtatttgcaaatgttcacaaatg ctaacaggaggctggtggtttgatgcatgtggtccttccaacttgaacggaatgtactat ccacagaggcagaacacaaataagttcaacggcattaaatggtactactggaaaggctca ggctattcgctcaaggccacaaccatgatgatccgaccagcagatttctaa

Homo sapiens (human): 51378 Help Entry 51378             CDS       T01001                                  Symbol ANGPT4, ANG3, ANG4 Name (RefSeq) angiopoietin 4   KO K05467   angiopoietin 4 Organism hsa  Homo sapiens (human) Pathway hsa04010   MAPK signaling pathway hsa04014   Ras signaling pathway hsa04015   Rap1 signaling pathway hsa04066   HIF-1 signaling pathway hsa04151   PI3K-Akt signaling pathway Network nt06526  MAPK signaling nt06530  PI3K signaling   Element N01592   GF-RTK-RAS-ERK signaling pathway N01656   GF-RTK-PI3K signaling pathway N01658   GF-RTK-RAS-PI3K signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     51378 (ANGPT4)    04014 Ras signaling pathway     51378 (ANGPT4)    04015 Rap1 signaling pathway     51378 (ANGPT4)    04066 HIF-1 signaling pathway     51378 (ANGPT4)    04151 PI3K-Akt signaling pathway     51378 (ANGPT4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:hsa04052]     51378 (ANGPT4) Cytokines and neuropeptides [BR:hsa04052]  Cytokines   Growth factors (RTK binding)    51378 (ANGPT4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Fibrinogen_C DcpS_C Motif Other DBs NCBI-GeneID:  51378 NCBI-ProteinID:  NP_057069 OMIM:  603705 HGNC:  487 Ensembl:  ENSG00000101280 Pharos:  Q9Y264(Tbio) UniProt:  Q9Y264 LinkDB All DBs Position 20:complement(869900..916334) Genome browser AA seq 503 aa AA seqDB search MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPE VSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQ QQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQ LLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERG LRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGAS ASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEH WLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQ SSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIR WHYFKGPSYSLRASRMMIRPLDI NT seq 1512 nt NT seq  +upstreamnt  +downstreamnt atgctctcccagctagccatgctgcagggcagcctcctccttgtggttgccaccatgtct gtggctcaacagacaaggcaggaggcggataggggctgcgagacacttgtagtccagcac ggccactgtagctacaccttcttgctgcccaagtctgagccctgccctccggggcctgag gtctccagggactccaacaccctccagagagaatcactggccaacccactgcacctgggg aagttgcccacccagcaggtgaaacagctggagcaggcactgcagaacaacacgcagtgg ctgaagaagctagagagggccatcaagacgatcttgaggtcgaagctggagcaggtccag cagcaaatggcccagaatcagacggcccccatgctagagctgggcaccagcctcctgaac cagaccactgcccagatccgcaagctgaccgacatggaggctcagctcctgaaccagaca tcaagaatggatgcccagatgccagagacctttctgtccaccaacaagctggagaaccag ctgctgctacagaggcagaagctccagcagcttcagggccaaaacagcgcgctcgagaag cggttgcaggccctggagaccaagcagcaggaggagctggccagcatcctcagcaagaag gcgaagctgctgaacacgctgagccgccagagcgccgccctcaccaacatcgagcgcggc ctgcgcggtgtcaggcacaactccagcctcctgcaggaccagcagcacagcctgcgccag ctgctggtgttgttgcggcacctggtgcaagaaagggctaacgcctcggccccggccttc ataatggcaggtgagcaggtgttccaggactgtgcagagatccagcgctctggggccagt gccagtggtgtctacaccatccaggtgtccaatgcaacgaagcccaggaaggtgttctgt gacctgcagagcagtggaggcaggtggaccctcatccagcgccgtgagaatggcaccgtg aattttcagcggaactggaaggattacaaacagggcttcggagacccagctggggagcac tggctgggcaatgaagtggtgcaccagctcaccagaagggcagcctactctctgcgtgtg gagctgcaagactgggaaggccacgaggcctatgcccagtacgaacatttccacctgggc agtgagaaccagctatacaggctttctgtggtcgggtacagcggctcagcagggcgccag agcagcctggtcctgcagaacaccagctttagcacccttgactcagacaacgaccactgt ctctgcaagtgtgcccaagtgatgtctggagggtggtggtttgacgcctgtggcctgtca aacctcaacggcgtctactaccacgctcccgacaacaagtacaagatggacggcatccgc tggcactacttcaagggccccagctactcactgcgtgcctctcgcatgatgatacggcct ttggacatctaa

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