KEGG T01001: 3028

Homo sapiens (human): 3028

Entry

3028              CDS       T01001

Symbol

HSD17B10, 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, HSD10MD, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1

Name

(RefSeq) hydroxysteroid 17-beta dehydrogenase 10

K08683

3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]

Organism

hsa Homo sapiens (human)

Pathway

hsa00280

Valine, leucine and isoleucine degradation

hsa01100

Metabolic pathways

hsa05010

Alzheimer disease

hsa05022

Pathways of neurodegeneration - multiple diseases

Network

nt06024 Valine, leucine and isoleucine degradation

Element

N00856

Isoleucine degradation

Disease

H00925

2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    3028 (HSD17B10)
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3028 (HSD17B10)
   05022 Pathways of neurodegeneration - multiple diseases
    3028 (HSD17B10)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3028 (HSD17B10)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3028 (HSD17B10)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     3028 (HSD17B10)
    1.1.1.178  3-hydroxy-2-methylbutyryl-CoA dehydrogenase
     3028 (HSD17B10)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Mitochondrial ribonuclease P
    3028 (HSD17B10)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of breast cancer cells
   3028 (HSD17B10)

SSDB

Motif

Pfam:

adh_short adh_short_C2 KR Epimerase

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

X:complement(53431258..53434376)

AA seq 261 aa
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
IENPFLNGEVIRLDGAIRMQP

NT seq 786 nt +upstreamnt +downstreamnt
atggcagcagcgtgtcggagcgtgaagggcctggtggcggtaataaccggaggagcctcg
ggcctgggcctggccacggcggagcgacttgtggggcagggagcctctgctgtgcttctg
gacctgcccaactcgggtggggaggcccaagccaagaagttaggaaacaactgcgttttc
gccccagccgacgtgacctctgagaaggatgtgcaaacagctctggctctagcaaaagga
aagtttggccgtgtggatgtagctgtcaactgtgcaggcatcgcggtggctagcaagacg
tacaacttaaagaagggccagacccataccttggaagacttccagcgagttcttgatgtg
aatctcatgggcaccttcaatgtgatccgcctggtggctggtgagatgggccagaatgaa
ccagaccagggaggccaacgtggggtcatcatcaacactgccagtgtggctgccttcgag
ggtcaggttggacaagctgcatactctgcttccaaggggggaatagtgggcatgacactg
cccattgctcgggatctggctcccataggtatccgggtgatgaccattgccccaggtctg
tttggcaccccactgctgaccagcctcccagagaaagtgtgcaacttcttggccagccaa
gtgcccttccctagccgactgggtgaccctgctgagtatgctcacctcgtacaggccatc
atcgagaacccattcctcaatggagaggtcatccggctggatggggccattcgtatgcag
ccttga

DBGET integrated database retrieval system