Homo sapiens (human): 328
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Entry
328 CDS
T01001
Symbol
APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1
Name
(RefSeq) apurinic/apyrimidinic endodeoxyribonuclease 1
KO
K10771
AP endonuclease 1 [EC:
3.1.11.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03410
Base excision repair
Network
nt06504
Base excision repair
Element
N01433
Base excision and strand cleavage by monofunctional glycosylase
N01434
Base excision and strand cleavage by bifunctional glycosylase
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03410 Base excision repair
328 (APEX1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
328 (APEX1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.11 Exodeoxyribonucleases producing 5'-phosphomonoesters
3.1.11.2 exodeoxyribonuclease III
328 (APEX1)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
BER (base exicision repair)
AP endonucleases
328 (APEX1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Exo_endo_phos
Exo_endo_phos_2
Motif
Other DBs
NCBI-GeneID:
328
NCBI-ProteinID:
NP_001231178
OMIM:
107748
HGNC:
587
Ensembl:
ENSG00000100823
UniProt:
P27695
Q5TZP7
Structure
PDB
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All DBs
Position
14:20455226..20457767
Genome browser
AA seq
318 aa
AA seq
DB search
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
NT seq
957 nt
NT seq
+upstream
nt +downstream
nt
atgccgaagcgtgggaaaaagggagcggtggcggaagacggggatgagctcaggacagag
ccagaggccaagaagagtaagacggccgcaaagaaaaatgacaaagaggcagcaggagag
ggcccagccctgtatgaggaccccccagatcagaaaacctcacccagtggcaaacctgcc
acactcaagatctgctcttggaatgtggatgggcttcgagcctggattaagaagaaagga
ttagattgggtaaaggaagaagccccagatatactgtgccttcaagagaccaaatgttca
gagaacaaactaccagctgaacttcaggagctgcctggactctctcatcaatactggtca
gctccttcggacaaggaagggtacagtggcgtgggcctgctttcccgccagtgcccactc
aaagtttcttacggcataggcgatgaggagcatgatcaggaaggccgggtgattgtggct
gaatttgactcgtttgtgctggtaacagcatatgtacctaatgcaggccgaggtctggta
cgactggagtaccggcagcgctgggatgaagcctttcgcaagttcctgaagggcctggct
tcccgaaagccccttgtgctgtgtggagacctcaatgtggcacatgaagaaattgacctt
cgcaaccccaaggggaacaaaaagaatgctggcttcacgccacaagagcgccaaggcttc
ggggaattactgcaggctgtgccactggctgacagctttaggcacctctaccccaacaca
ccctatgcctacaccttttggacttatatgatgaatgctcgatccaagaatgttggttgg
cgccttgattactttttgttgtcccactctctgttacctgcattgtgtgacagcaagatc
cgttccaaggccctcggcagtgatcactgtcctatcaccctatacctagcactgtga
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