KEGG   Homo sapiens (human): 328
Entry
328               CDS       T01001                                 
Symbol
APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1
Name
(RefSeq) apurinic/apyrimidinic endodeoxyribonuclease 1
  KO
K10771  AP endonuclease 1 [EC:4.2.99.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
Network
nt06504  Base excision repair
  Element
N01433  Base excision and strand cleavage by monofunctional glycosylase
N01434  Base excision and strand cleavage by bifunctional glycosylase
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    328 (APEX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    328 (APEX1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.99  Other carbon-oxygen lyases
    4.2.99.18  DNA-(apurinic or apyrimidinic site) lyase
     328 (APEX1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    AP endonucleases
     328 (APEX1)
SSDB
Motif
Pfam: Exo_endo_phos Exo_endo_phos_2
Other DBs
NCBI-GeneID: 328
NCBI-ProteinID: NP_001231178
OMIM: 107748
HGNC: 587
Ensembl: ENSG00000100823
Pharos: P27695(Tchem)
UniProt: P27695 Q5TZP7
Structure
LinkDB
Position
14:20455226..20457767
AA seq 318 aa
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
NT seq 957 nt   +upstreamnt  +downstreamnt
atgccgaagcgtgggaaaaagggagcggtggcggaagacggggatgagctcaggacagag
ccagaggccaagaagagtaagacggccgcaaagaaaaatgacaaagaggcagcaggagag
ggcccagccctgtatgaggaccccccagatcagaaaacctcacccagtggcaaacctgcc
acactcaagatctgctcttggaatgtggatgggcttcgagcctggattaagaagaaagga
ttagattgggtaaaggaagaagccccagatatactgtgccttcaagagaccaaatgttca
gagaacaaactaccagctgaacttcaggagctgcctggactctctcatcaatactggtca
gctccttcggacaaggaagggtacagtggcgtgggcctgctttcccgccagtgcccactc
aaagtttcttacggcataggcgatgaggagcatgatcaggaaggccgggtgattgtggct
gaatttgactcgtttgtgctggtaacagcatatgtacctaatgcaggccgaggtctggta
cgactggagtaccggcagcgctgggatgaagcctttcgcaagttcctgaagggcctggct
tcccgaaagccccttgtgctgtgtggagacctcaatgtggcacatgaagaaattgacctt
cgcaaccccaaggggaacaaaaagaatgctggcttcacgccacaagagcgccaaggcttc
ggggaattactgcaggctgtgccactggctgacagctttaggcacctctaccccaacaca
ccctatgcctacaccttttggacttatatgatgaatgctcgatccaagaatgttggttgg
cgccttgattactttttgttgtcccactctctgttacctgcattgtgtgacagcaagatc
cgttccaaggccctcggcagtgatcactgtcctatcaccctatacctagcactgtga

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