KEGG   NETWORK: N01433
Entry
N01433                      Network                                
Name
Base excision and strand cleavage by monofunctional glycosylase
Definition
glycosylase -> APEX == POLB
  Expanded
7374,4595,23583,4350,8930,6996 -> (328,27301) == 5423
Class
nt06504 Base excision repair
Type
Reference
Pathway
hsa03410  Base excision repair
Gene
7374  UNG; uracil DNA glycosylase
4595  MUTYH; mutY DNA glycosylase
23583  SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1
4350  MPG; N-methylpurine DNA glycosylase
8930  MBD4; methyl-CpG binding domain 4, DNA glycosylase
6996  TDG; thymine DNA glycosylase
328  APEX1; apurinic/apyrimidinic endodeoxyribonuclease 1
27301  APEX2; apurinic/apyrimidinic endodeoxyribonuclease 2
5423  POLB; DNA polymerase beta
Reference
  Authors
Grundy GJ, Parsons JL
  Title
Base excision repair and its implications to cancer therapy.
  Journal
Essays Biochem 64:831-843 (2020)
DOI:10.1042/EBC20200013
Reference
  Authors
Robertson AB, Klungland A, Rognes T, Leiros I
  Title
DNA repair in mammalian cells: Base excision repair: the long and short of it.
  Journal
Cell Mol Life Sci 66:981-93 (2009)
DOI:10.1007/s00018-009-8736-z
Reference
  Authors
Hegde ML, Hazra TK, Mitra S
  Title
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.
  Journal
Cell Res 18:27-47 (2008)
DOI:10.1038/cr.2008.8
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