Entry |
|
Symbol |
HSD3B2, HSD3B, HSDB, SDR11E2
|
Name |
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
|
KO |
|
Organism |
|
Pathway |
hsa04925 | Aldosterone synthesis and secretion |
hsa04927 | Cortisol synthesis and secretion |
|
Module |
hsa_M00107 | Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone |
hsa_M00110 | C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone |
hsa_M00976 | C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone |
hsa_M00977 | C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone |
|
Network |
nt06019 Steroid hormone biosynthesis |
Element |
N00759 | Steroid hormone biosynthesis, cholesterol to pregnenolone/progesterone |
N01541 | Testosterone biosynthesis |
N01802 | Dihydrotestosterone biosynthesis |
|
Disease |
H00216 | Congenital adrenal hyperplasia |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
3284 (HSD3B2)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
3284 (HSD3B2)
04925 Aldosterone synthesis and secretion
3284 (HSD3B2)
04927 Cortisol synthesis and secretion
3284 (HSD3B2)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
3284 (HSD3B2)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
3284 (HSD3B2)
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
3284 (HSD3B2)
|
SSDB |
|
Motif |
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Other DBs |
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LinkDB |
|
Position |
1:119414931..119423034
|
AA seq |
372 aa
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFI
YTSSIEVAGPNSYKEIIQNGHEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDTLY
TCALRPTYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALR
DPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLDSRWSLPLTLMYWIGFLLEVV
SFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLV
DRHKETLKSKTQ |
NT seq |
1119 nt +upstreamnt +downstreamnt
atgggctggagctgccttgtgacaggagcaggagggcttctgggtcagaggatcgtccgc
ctgttggtggaagagaaggaactgaaggagatcagggccttggacaaggccttcagacca
gaattgagagaggaattttctaagctccagaacaggaccaagctgactgtacttgaagga
gacattctggatgagccattcctgaaaagagcctgccaggacgtctcggtcgtcatccac
accgcctgtatcattgatgtctttggtgtcactcacagagagtccatcatgaatgtcaat
gtgaaaggtacccagctactgttggaggcctgtgtccaagccagtgtgccagtcttcatc
tacaccagtagcatagaggtagccgggcccaactcctacaaggaaatcatccagaacggc
cacgaagaagagcctctggaaaacacatggcccactccatacccgtacagcaaaaagctt
gctgagaaggctgtgctggcggctaatgggtggaatctaaaaaatggtgataccttgtac
acttgtgcgttaagacccacatatatctatggggaaggaggcccattcctttctgccagt
ataaatgaggccctgaacaacaatgggatcctgtcaagtgttggaaagttctctacagtc
aacccagtctatgttggcaacgtggcctgggcccacattctggccttgagggctctgcgg
gaccccaagaaggccccaagtgtccgaggtcaattctattacatctcagatgacacgcct
caccaaagctatgataaccttaattacatcctgagcaaagagtttggcctccgccttgat
tccagatggagccttcctttaaccctgatgtactggattggcttcctgctggaagtagtg
agcttcctactcagcccaatttactcctatcaaccccccttcaaccgccacacagtcaca
ttatcaaatagtgtgttcaccttctcttacaagaaggctcagcgagatctggcgtataag
ccactctacagctgggaggaagccaagcagaaaaccgtggagtgggttggttcccttgtg
gaccggcacaaggagaccctgaagtccaagactcagtga |