KEGG   NETWORK: N01802
Entry
N01802                      Network                                
Name
Dihydrotestosterone biosynthesis
Definition
Pregnenolone -- CYP17A1 >> HSD3B1/2 >> SRD5A1 >> (HSD17B6,AKR1C2/4) >> (AKR1C3,HSD17B3) >> (AKR1C2,HSD17B6) -> DHT
  Expanded
C01953 -- 1586 >> (3283,3284) >> 6715 >> (8630,1646,1109) >> (8644,3293) >> (1646,8630) -> C03917
Class
nt06019 Steroid hormone biosynthesis
Type
Reference
Pathway
hsa00140  Steroid hormone biosynthesis
Gene
1586  CYP17A1; cytochrome P450 family 17 subfamily A member 1
3283  HSD3B1; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
3284  HSD3B2; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
6715  SRD5A1; steroid 5 alpha-reductase 1
8630  HSD17B6; hydroxysteroid 17-beta dehydrogenase 6
1646  AKR1C2; aldo-keto reductase family 1 member C2
1109  AKR1C4; aldo-keto reductase family 1 member C4
8644  AKR1C3; aldo-keto reductase family 1 member C3
3293  HSD17B3; hydroxysteroid 17-beta dehydrogenase 3
Metabolite
C01953  Pregnenolone
C03917  Dihydrotestosterone
Reference
PMID:30943210
  Authors
Miller WL, Auchus RJ
  Title
The "backdoor pathway" of androgen synthesis in human male sexual development.
  Journal
PLoS Biol 17:e3000198 (2019)
DOI:10.1371/journal.pbio.3000198
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