Homo sapiens (human): 3290
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Entry
3290 CDS
T01001
Symbol
HSD11B1, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
KO
K15680
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:
1.1.1.146
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa00980
Metabolism of xenobiotics by cytochrome P450
hsa01100
Metabolic pathways
hsa05204
Chemical carcinogenesis - DNA adducts
Module
hsa_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Network
nt06019
Steroid hormone biosynthesis
nt06250
DNA adduct formation
Element
N00309
Cortisone reduction
N00310
Mutation-inactivated HED11B1 to cortisone reduction
N01381
NNK to DNA adducts
N01382
NNK to DNA adducts
Disease
H01111
Cortisone reductase deficiency
Drug target
Carbenoxolone (
DG00024
):
D01899
D07615
Enoxolone:
D00156
<JP>
Glycyrrhizic acid (
DG03217
):
D02028
D02264
<JP>
D04987
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
3290 (HSD11B1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
3290 (HSD11B1)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
3290 (HSD11B1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.146 11beta-hydroxysteroid dehydrogenase
3290 (HSD11B1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
DUF1776
THF_DHG_CYH_C
Pyr_redox_2
Shikimate_DH
2-Hacid_dh_C
Pyr_redox_3
NAD_binding_2
SIS
NAD_binding_7
AdoHcyase_NAD
Motif
Other DBs
NCBI-GeneID:
3290
NCBI-ProteinID:
NP_001193670
OMIM:
600713
HGNC:
5208
Ensembl:
ENSG00000117594
Pharos:
P28845
(Tclin)
UniProt:
P28845
X5D2L1
Structure
PDB
LinkDB
All DBs
Position
1:209686179..209734929
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AA seq
292 aa
AA seq
DB search
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
NT seq
879 nt
NT seq
+upstream
nt +downstream
nt
atggcttttatgaaaaaatatctcctccccattctggggctcttcatggcctactactac
tattctgcaaacgaggaattcagaccagagatgctccaaggaaagaaagtgattgtcaca
ggggccagcaaagggatcggaagagagatggcttatcatctggcgaagatgggagcccat
gtggtggtgacagcgaggtcaaaagaaactctacagaaggtggtatcccactgcctggag
cttggagcagcctcagcacactacattgctggcaccatggaagacatgaccttcgcagag
caatttgttgcccaagcaggaaagctcatgggaggactagacatgctcattctcaaccac
atcaccaacacttctttgaatctttttcatgatgatattcaccatgtgcgcaaaagcatg
gaagtcaacttcctcagttacgtggtcctgactgtagctgccttgcccatgctgaagcag
agcaatggaagcattgttgtcgtctcctctctggctgggaaagtggcttatccaatggtt
gctgcctattctgcaagcaagtttgctttggatgggttcttctcctccatcagaaaggaa
tattcagtgtccagggtcaatgtatcaatcactctctgtgttcttggcctcatagacaca
gaaacagccatgaaggcagtttctgggatagtccatatgcaagcagctccaaaggaggaa
tgtgccctggagatcatcaaagggggagctctgcgccaagaagaagtgtattatgacagc
tcactctggaccactcttctgatcagaaatccatgcaggaagatcctggaatttctctac
tcaacgagctataatatggacagattcataaacaagtag
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