KEGG   NETWORK: N01382
Entry
N01382                      Network                                
Name
NNK to DNA adducts
Definition
NNK -- (AKR1C2,CBR1,HSD11B1) >> (CYP2A6,CYP2A13) -> C19580 -> C19581 == DNA
  Expanded
C16453 -- (1646,873,3290) >> (1548,1553) -> C19580 -> C19581 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
1646  AKR1C2; aldo-keto reductase family 1 member C2
873  CBR1; carbonyl reductase 1
3290  HSD11B1; hydroxysteroid 11-beta dehydrogenase 1
1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6
1553  CYP2A13; cytochrome P450 family 2 subfamily A member 13
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Metabolite
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C00039  DNA
Reference
PMID:21473878
  Authors
Chiang HC, Wang CY, Lee HL, Tsou TC
  Title
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
  Journal
Toxicol Appl Pharmacol 253:145-52 (2011)
DOI:10.1016/j.taap.2011.03.022
Reference
PMID:21154658
  Authors
Bhat SH, Gelhaus SL, Mesaros C, Vachani A, Blair IA
  Title
A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine.
  Journal
Rapid Commun Mass Spectrom 25:115-21 (2011)
DOI:10.1002/rcm.4824
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