KEGG   Homo sapiens (human): 3293
Entry
3293              CDS       T01001                                 
Symbol
HSD17B3, EDH17B3, SDR12C2
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 3
  KO
K10207  testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Disease
H00608  46,XY disorder of sex development due to testosterone secretion defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3293 (HSD17B3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.64  testosterone 17beta-dehydrogenase (NADP+)
     3293 (HSD17B3)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Sacchrp_dh_NADP ApbA Shikimate_DH DUF3993
Other DBs
NCBI-GeneID: 3293
NCBI-ProteinID: NP_000188
OMIM: 605573
HGNC: 5212
Ensembl: ENSG00000130948
UniProt: P37058 Q6FH62
LinkDB
Position
9:complement(96235306..96302176)
AA seq 310 aa
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
NT seq 933 nt   +upstreamnt  +downstreamnt
atgggggacgtcctggaacagttcttcatcctcacagggctgctggtgtgcctggcctgc
ctggcgaagtgcgtgagattctccagatgtgttttactgaactactggaaagttttgcca
aagtctttcttgcggtcaatgggacagtgggcagtgatcactggagcaggcgatggaatt
gggaaagcgtactcgttcgagctagcaaaacgtggactcaatgttgtccttattagccgg
acgctggaaaaactagaggccattgccacagagatcgagcggactacagggaggagtgtg
aagattatacaagcagattttacaaaagatgacatctacgagcatattaaagaaaaactt
gcaggcttagaaattggaattttagtcaacaatgtcggaatgcttccaaaccttctccca
agccatttcctgaacgcaccggatgaaatccagagcctcatccattgtaacatcacctcc
gtagtcaagatgacacagctaattctgaaacatatggaatcaaggcagaaaggtctcatc
ctgaacatttcttctgggatagccctgtttccttggcctctctactccatgtactcagct
tccaaggcgtttgtgtgcgcattttccaaggccctgcaagaggaatataaagcaaaagaa
gtcatcatccaggtgctgaccccatatgctgtctcgactgcaatgacaaagtatctaaat
acaaatgtgataaccaagactgctgatgagtttgtcaaagagtcattgaattatgtcaca
attggaggtgaaacctgtggctgccttgcccatgaaatcttggcgggctttctgagcctg
atcccggcctgggccttctacagcggtgccttccaaaggctgctcctgacacactatgtg
gcatacctgaagctcaacaccaaggtcaggtag

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