KEGG   Homo sapiens (human): 340811
Entry
340811            CDS       T01001                                 
Symbol
AKR1C8, AKR1C8P, AKR1CL1
Name
(RefSeq) aldo-keto reductase family 1 member C8
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    340811 (AKR1C8)
   00590 Arachidonic acid metabolism
    340811 (AKR1C8)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    340811 (AKR1C8)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    340811 (AKR1C8)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    340811 (AKR1C8)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     340811 (AKR1C8)
    1.1.1.188  prostaglandin-F synthase
     340811 (AKR1C8)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     340811 (AKR1C8)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     340811 (AKR1C8)
SSDB
Motif
Pfam: Aldo_ket_red E2-E1mid DUF5376
Other DBs
NCBI-GeneID: 340811
NCBI-ProteinID: NP_001382901
HGNC: 23469
Ensembl: ENSG00000264006
UniProt: Q5T2L2
LinkDB
Position
10:complement(5115813..5185150)
AA seq 326 aa
MMTDLKQSHSVRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKVAIDVGFRHIDSAYLYQN
EEEVGQAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIH
VPFAMKPGKELLPKDASGEIILETVELCDTWEALEKCKEAGLTRSIGVSNFNHKLLELIL
NKPGLKYKPTCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRDPQWVDPDCPHLLE
EPILKSIAKKHSGSPGQVALRYQLQRGVVVLAKSFSQERIKENFQIFDFELTPEDMKAID
GLNRNLRYDKLQFAANHPYFPFSEEY
NT seq 981 nt   +upstreamnt  +downstreamnt
atgatgacggatctgaagcaaagccattcagtgaggctgaatgatggacccttcatgcca
gtgctgggatttggcacttatgctcctgatcatactcccaaaagccaggctgccgaggcc
accaaagtggctattgacgtaggcttccgccatattgattcagcatacttataccaaaat
gaggaggaggttggacaggccatttgggagaagatcgctgatggtaccgtcaagagagag
gaaatattctacaccatcaagctttgggctactttctttcgggcagaattggttcacccg
gccctagaaaggtcactgaagaaacttggaccggactatgtagatctcttcattattcat
gtaccatttgctatgaagcctgggaaagaattactgccaaaggatgccagtggagagatt
attttagaaactgtggagctttgtgacacttgggaggccctggagaagtgcaaagaagca
ggtttaaccaggtccattggggtgtccaatttcaatcacaagctgctggaactcatcctc
aacaagccagggctcaagtacaagcccacctgcaaccaggtggaatgtcacccttacctc
aaccagagcaaactcctggagttctgcaagtccaaggacattgttctagttgcctacagt
gccctgggatcccaaagagacccacagtgggtggatcccgactgcccacatctcttggag
gagccgatcttgaaatccattgccaagaaacacagtggaagcccaggccaggtcgccctg
cgctaccagctgcagcggggagtggtggtgctggccaagagcttctctcaggagagaatc
aaagagaacttccagatttttgactttgagttgactccagaggacatgaaagccattgat
ggcctcaacagaaatctccgatatgacaagttacaatttgctgctaatcacccttatttt
ccattttctgaagaatattga

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