KEGG   Homo sapiens (human): 3426
Entry
3426              CDS       T01001                                 
Symbol
CFI, AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF
Name
(RefSeq) complement factor I
  KO
K01333  complement factor I [EC:3.4.21.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
Network
nt06513  Complement cascade
  Element
N01495  Classical/Lectin pathway of complement cascade, C4b breakdown
N01496  Alternative pathway of complement cascade, C3b breakdown
N01527  KSHV Kaposin to classical/Lectin pathway of complement cascade, C4b breakdown
N01528  KSHV Kaposin to alternative pathway of complement cascade, C3b breakdown
Disease
H00106  Complement regulatory protein defects
H00821  Age-related macular degeneration
H01434  Atypical hemolytic uremic syndrome
H02579  C3 glomerulopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3426 (CFI)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3426 (CFI)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3426 (CFI)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3426 (CFI)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.45  complement factor I
     3426 (CFI)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   3426 (CFI)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3426 (CFI)
SSDB
Motif
Pfam: Trypsin CFAI_KAZAL Ldl_recept_a CFAI_FIMAC_N SRCR C7_KAZAL Trypsin_2
Other DBs
NCBI-GeneID: 3426
NCBI-ProteinID: NP_000195
OMIM: 217030
HGNC: 5394
Ensembl: ENSG00000205403
UniProt: P05156 A8K3L0
Structure
LinkDB
Position
4:complement(109730982..109801999)
AA seq 583 aa
MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
NT seq 1752 nt   +upstreamnt  +downstreamnt
atgaagcttcttcatgttttcctgttatttctgtgcttccacttaaggttttgcaaggtc
acttatacatctcaagaggatctggtggagaaaaagtgcttagcaaaaaaatatactcac
ctctcctgcgataaagtcttctgccagccatggcagagatgcattgagggcacctgtgtt
tgtaaactaccgtatcagtgcccaaagaatggcactgcagtgtgtgcaactaacaggaga
agcttcccaacatactgtcaacaaaagagtttggaatgtcttcatccagggacaaagttt
ttaaataacggaacatgcacagccgaaggaaagtttagtgtttccttgaagcatggaaat
acagattcagagggaatagttgaagtaaaacttgtggaccaagataagacaatgttcata
tgcaaaagcagctggagcatgagggaagccaacgtggcctgccttgaccttgggtttcaa
caaggtgctgatactcaaagaaggtttaagttgtctgatctctctataaattccactgaa
tgtctacatgtgcattgccgaggattagagaccagtttggctgaatgtacttttactaag
agaagaactatgggttaccaggatttcgctgatgtggtttgttatacacagaaagcagat
tctccaatggatgacttctttcagtgtgtgaatgggaaatacatttctcagatgaaagcc
tgtgatggtatcaatgattgtggagaccaaagtgatgaactgtgttgtaaagcatgccaa
ggcaaaggcttccattgcaaatcgggtgtttgcattccaagccagtatcaatgcaatggt
gaggtggactgcattacaggggaagatgaagttggctgtgcaggctttgcatctgtgact
caagaagaaacagaaattttgactgctgacatggatgcagaaagaagacggataaaatca
ttattacctaaactatcttgtggagttaaaaacagaatgcacattcgaaggaaacgaatt
gtgggaggaaagcgagcacaactgggagacctcccatggcaggtggcaattaaggatgcc
agtggaatcacctgtgggggaatttatattggtggctgttggattctgactgctgcacat
tgtctcagagccagtaaaactcatcgttaccaaatatggacaacagtagtagactggata
caccccgaccttaaacgtatagtaattgaatacgtggatagaattattttccatgaaaac
tacaatgcaggcacttaccaaaatgacatcgctttgattgaaatgaaaaaagacggaaac
aaaaaagattgtgagctgcctcgttccatccctgcctgtgtcccctggtctccttaccta
ttccaacctaatgatacatgcatcgtttctggctggggacgagaaaaagataacgaaaga
gtcttttcacttcagtggggtgaagttaaactaataagcaactgctctaagttttacgga
aatcgtttctatgaaaaagaaatggaatgtgcaggtacatatgatggttccatcgatgcc
tgtaaaggggactctggaggccccttagtctgtatggatgccaacaatgtgacttatgtc
tggggtgttgtgagttggggggaaaactgtggaaaaccagagttcccaggtgtttacacc
aaagtggccaattattttgactggattagctaccatgtaggaaggccttttatttctcag
tacaatgtataa

KEGG   ORTHOLOGY: K21649
Entry
K21649            Tight     KO                                     
Symbol
ORF4
Name
KSHV complement control protein
Pathway
map05167  Kaposi sarcoma-associated herpesvirus infection
map05203  Viral carcinogenesis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06513  Complement cascade
  Element
N00213  KSHV Kaposin to alternative pathway of complement cascade
N01527  KSHV Kaposin to classical/Lectin pathway of complement cascade, C4b breakdown
N01528  KSHV Kaposin to alternative pathway of complement cascade, C3b breakdown
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K21649  ORF4; KSHV complement control protein
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K21649  ORF4; KSHV complement control protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K21649  ORF4; KSHV complement control protein
Viral proteins [BR:ko03200]
 dsDNA viruses
  Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8)
   K21649  ORF4; KSHV complement control protein
Virus entry [br03220.html]
 Viral entry protein - non-protein receptor interactions
  K21649
Genes
VG: 4961488(ORF4)
Reference
PMID:12477863
  Authors
Spiller OB, Robinson M, O'Donnell E, Milligan S, Morgan BP, Davison AJ, Blackbourn DJ
  Title
Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein.
  Journal
J Virol 77:592-9 (2003)
DOI:10.1128/JVI.77.1.592-599.2003
  Sequence
[vg:4961488]
LinkDB

DBGET integrated database retrieval system