Homo sapiens (human): 3667 Help Entry 3667              CDS       T01001                                  Symbol IRS1, HIRS-1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04068   FoxO signaling pathway hsa04081   Hormone signaling hsa04140   Autophagy - animal hsa04150   mTOR signaling pathway hsa04151   PI3K-Akt signaling pathway hsa04152   AMPK signaling pathway hsa04211   Longevity regulating pathway hsa04213   Longevity regulating pathway - multiple species hsa04722   Neurotrophin signaling pathway hsa04910   Insulin signaling pathway hsa04920   Adipocytokine signaling pathway hsa04923   Regulation of lipolysis in adipocytes hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04932   Non-alcoholic fatty liver disease hsa04935   Growth hormone synthesis, secretion and action hsa04960   Aldosterone-regulated sodium reabsorption hsa05010   Alzheimer disease hsa05206   MicroRNAs in cancer hsa05415   Diabetic cardiomyopathy Network nt06325  Hormone/cytokine signaling   Element N01708   INS-AKT signaling pathway Disease H00409   Type 2 diabetes mellitus Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     3667 (IRS1)    04022 cGMP-PKG signaling pathway     3667 (IRS1)    04151 PI3K-Akt signaling pathway     3667 (IRS1)    04152 AMPK signaling pathway     3667 (IRS1)    04150 mTOR signaling pathway     3667 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     3667 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     3667 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     3667 (IRS1)    04923 Regulation of lipolysis in adipocytes     3667 (IRS1)    04920 Adipocytokine signaling pathway     3667 (IRS1)    04935 Growth hormone synthesis, secretion and action     3667 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     3667 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     3667 (IRS1)   09149 Aging    04211 Longevity regulating pathway     3667 (IRS1)    04213 Longevity regulating pathway - multiple species     3667 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     3667 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     3667 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     3667 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     3667 (IRS1)    04932 Non-alcoholic fatty liver disease     3667 (IRS1)    04931 Insulin resistance     3667 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  3667 NCBI-ProteinID:  NP_005535 OMIM:  147545 HGNC:  6125 Ensembl:  ENSG00000169047 UniProt:  P35568 Structure PDBPDBj LinkDB All DBs Position 2:complement(226731312..226799820) Genome browser AA seq 1242 aa AA seqDB search MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHR PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIE FGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKR HSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ NT seq 3729 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac cacgacggagctgcggccctcggggcgggaggtggtgggggcagctgcagcggcagctcc ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc aaagaggtctggcaagtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctttgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcagcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggaaaacttc ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc cgccgatcacgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccggcttcc cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag gagctaagcaactatatctgcatgggtggcaaggggccctccaccctgaccgcccccaac ggtcactacattttgtctcggggtggcaatggccaccgctgcaccccaggaacaggcttg ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg tcccagtcctcagtggcttccattgaggagtacacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccgc tcctacccagaggagggtctggaaatgcaccccttggagcgtcggggggggcaccaccgc ccagacagctccaccctccacacggatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagtggccgaaagggcagtggagactatatgcccatgagccccaagagcgta tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc agcagcagcagcagcagcaacgccgtcccttccgggaccagctatggaaagctgtggaca aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc agcggtggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggac tccaacaccagcagcccctccgactgctactacggccctgaggacccccagcacaagcca gtcctctcctactactcattgccaagatcctttaagcacacccagcgccccggggagccg gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat gctgcaacagcagatgattcttcctcttccaccagcagcgacagcctgggtgggggatac tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgagg ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag cagcagcccttgctgcaccctccagagcccaagagcccgggggaatatgtcaatattgaa tttgggagtgatcagtctggctacttgtctggcccggtggctttccacagctcaccttct gtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcactgaggag tacatgaagatggacctggggccgggccggagggcagcctggcaggagagcactggggtc gagatgggcagactgggccctgcacctcccggggctgctagcatttgcaggcctacccgg gcagtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagc tacgtggacacctcgccagctgcccctgtaagctatgctgacatgcgaacaggcattgct gcagaggaggtgagcctgcccagggccaccatggctgctgcctcctcatcctcagcagcc tctgcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctg gggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaac cgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagc tccgagactttctcctcaacacccagtgccacccgggtgggcaacacagtgccctttgga gcgggggcagcagtagggggcggtggcggtagcagcagcagcagcgaggatgtgaaacgc cacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagccccc aaggagccagccaaactgtgtggggctgctgggggtttggagaatggtcttaactacata gacctggatttggtcaaggacttcaaacagtgccctcaggagtgcacccctgaaccgcag cctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacccgc cgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggac cgtcagtag

DBGET integrated database retrieval system