Homo sapiens (human): 3683
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Entry
3683 CDS
T01001
Symbol
ITGAL, CD11A, LFA-1, LFA1A
Name
(RefSeq) integrin subunit alpha L
KO
K05718
integrin alpha L
Organism
hsa
Homo sapiens (human)
Pathway
hsa04015
Rap1 signaling pathway
hsa04514
Cell adhesion molecules
hsa04613
Neutrophil extracellular trap formation
hsa04650
Natural killer cell mediated cytotoxicity
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa05144
Malaria
hsa05150
Staphylococcus aureus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05323
Rheumatoid arthritis
hsa05416
Viral myocarditis
Drug target
Antithymocyte immunoglobulin (rabbit):
D09190
<JP/US>
Efalizumab:
D03959
Erlizumab:
D04045
Lifitegrast (
DG01389
):
D10374
<US>
D10392
Rovelizumab:
D08993
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
3683 (ITGAL)
09133 Signaling molecules and interaction
04514 Cell adhesion molecules
3683 (ITGAL)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
3683 (ITGAL)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
3683 (ITGAL)
04650 Natural killer cell mediated cytotoxicity
3683 (ITGAL)
04670 Leukocyte transendothelial migration
3683 (ITGAL)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3683 (ITGAL)
05169 Epstein-Barr virus infection
3683 (ITGAL)
09171 Infectious disease: bacterial
05150 Staphylococcus aureus infection
3683 (ITGAL)
09174 Infectious disease: parasitic
05144 Malaria
3683 (ITGAL)
09163 Immune disease
05323 Rheumatoid arthritis
3683 (ITGAL)
09166 Cardiovascular disease
05416 Viral myocarditis
3683 (ITGAL)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3683 (ITGAL)
04515 Cell adhesion molecules [BR:
hsa04515
]
3683 (ITGAL)
04090 CD molecules [BR:
hsa04090
]
3683 (ITGAL)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3683 (ITGAL)
Cell adhesion molecules [BR:
hsa04515
]
Integrins
Integrin alpha subunits
3683 (ITGAL)
CD molecules [BR:
hsa04090
]
Proteins
3683 (ITGAL)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
VWA
FG-GAP
Integrin_A_Ig_2
Integrin_A_Ig_1
FG-GAP_3
FG-GAP_2
Integrin_alpha
ITGAX-like_Ig_3
Filamin
Motif
Other DBs
NCBI-GeneID:
3683
NCBI-ProteinID:
NP_002200
OMIM:
153370
HGNC:
6148
Ensembl:
ENSG00000005844
UniProt:
P20701
B2RAL6
Structure
PDB
PDBj
LinkDB
All DBs
Position
16:30472742..30523185
Genome browser
AA seq
1170 aa
AA seq
DB search
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCD
QNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMK
DVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYV
ATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSR
GHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLL
ASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLI
GAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVA
VGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLI
PQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQD
LISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEAN
LRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQ
IPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPS
IHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFR
CPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMK
VDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDS
EQLASGQEAGDPGCLKPLHEKDSESGGGKD
NT seq
3513 nt
NT seq
+upstream
nt +downstream
nt
atgaaggattcctgcatcactgtgatggccatggcgctgctgtctgggttctttttcttc
gcgccggcctcgagctacaacctggacgtgcggggcgcgcggagcttctccccaccgcgc
gccgggaggcactttggataccgcgtcctgcaggtcggaaacggggtcatcgtgggagct
ccaggggaggggaacagcacaggaagcctctatcagtgccagtcgggcacaggacactgc
ctgccagtcaccctgagaggttccaactatacctccaagtacttgggaatgaccttggca
acagaccccacagatggaagcattttggcctgtgaccctgggctgtctcgaacgtgtgac
cagaacacctatctgagtggcctgtgttacctcttccgccagaatctgcagggtcccatg
ctgcaggggcgccctggttttcaggaatgtatcaagggcaacgtagacctggtatttctg
tttgatggttcgatgagcttgcagccagatgaatttcagaaaattctggacttcatgaag
gatgtgatgaagaaactcagcaacacttcgtaccagtttgctgctgttcagttttccaca
agctacaaaacagaatttgatttctcagattatgttaaacggaaggaccctgatgctctg
ctgaagcatgtaaagcacatgttgctgttgaccaatacctttggtgccatcaattatgtc
gcgacagaggtgttccgggaggagctgggggcccggccagatgccaccaaagtgcttatc
atcatcacggatggggaggccactgacagtggcaacatcgatgcggccaaagacatcatc
cgctacatcatcgggattggaaagcattttcagaccaaggagagtcaggagaccctccac
aaatttgcatcaaaacccgcgagcgagtttgtgaaaattctggacacatttgagaagctg
aaagatctattcactgagctgcagaagaagatctatgtcattgagggcacaagcaaacag
gacctgacttccttcaacatggagctgtcctccagcggcatcagtgctgacctcagcagg
ggccatgcagtcgtgggggcagtaggagccaaggactgggctgggggctttcttgacctg
aaggcagacctgcaggatgacacatttattgggaatgaaccattgacaccagaagtgaga
gcaggctatttgggttacaccgtgacctggctgccctcccggcaaaagacttcgttgctg
gcctcgggagcccctcgataccagcacatgggccgagtgctgctgttccaagagccacag
ggcggaggacactggagccaggtccagacaatccatgggacccagattggctcttatttc
ggtggggagctgtgtggcgtcgacgtggaccaagatggggagacagagctgctgctgatt
ggtgccccactgttctatggggagcagagaggaggccgggtgtttatctaccagagaaga
cagttggggtttgaagaagtctcagagctgcagggggaccccggctacccactcgggcgg
tttggagaagccatcactgctctgacagacatcaacggcgatgggctggtagacgtggct
gtgggggcccctctggaggagcagggggctgtgtacatcttcaatgggaggcacgggggg
cttagtccccagccaagtcagcggatagaagggacccaagtgctctcaggaattcagtgg
tttggacgctccatccatggggtgaaggaccttgaaggggatggcttggcagatgtggct
gtgggggctgagagccagatgatcgtgctgagctcccggcccgtggtggatatggtcacc
ctgatgtccttctctccagctgagatcccagtgcatgaagtggagtgctcctattcaacc
agtaacaagatgaaagaaggagttaatatcacaatctgtttccagatcaagtctctcatc
ccccagttccaaggccgcctggttgccaatctcacttacactctgcagctggatggccac
cggaccagaagacgggggttgttcccaggagggagacatgaactcagaaggaatatagct
gtcaccaccagcatgtcatgcactgacttctcatttcatttcccggtatgtgttcaagac
ctcatctcccccatcaatgtttccctgaatttctctctttgggaggaggaagggacaccg
agggaccaaagggcgcagggcaaggacataccgcccatcctgagaccctccctgcactcg
gaaacctgggagatcccttttgagaagaactgtggggaggacaagaagtgtgaggcaaac
ttgagagtgtccttctctcctgcaagatccagagccctgcgtctaactgcttttgccagc
ctctctgtggagctgagcctgagtaacttggaagaagatgcttactgggtccagctggac
ctgcacttccccccgggactctccttccgcaaggtggagatgctgaagccccatagccag
atacctgtgagctgcgaggagcttcctgaagagtccaggcttctgtccagggcattatct
tgcaatgtgagctctcccatcttcaaagcaggccactcggttgctctgcagatgatgttt
aatacactggtaaacagctcctggggggactcggttgaattgcacgccaatgtgacctgt
aacaatgaggactcagacctcctggaggacaactcagccactaccatcatccccatcctg
taccccatcaacatcctcatccaggaccaagaagactccacactctatgtcagtttcacc
cccaaaggccccaagatccaccaagtcaagcacatgtaccaggtgaggatccagccttcc
atccacgaccacaacatacccaccctggaggctgtggttggggtgccacagcctcccagc
gaggggcccatcacacaccagtggagcgtgcagatggagcctcccgtgccctgccactat
gaggatctggagaggctcccggatgcagctgagccttgtctccccggagccctgttccgc
tgccctgttgtcttcaggcaggagatcctcgtccaagtgatcgggactctggagctggtg
ggagagatcgaggcctcttccatgttcagcctctgcagctccctctccatctccttcaac
agcagcaagcatttccacctctatggcagcaacgcctccctggcccaggttgtcatgaag
gttgacgtggtgtatgagaagcagatgctctacctctacgtgctgagcggcatcgggggg
ctgctgctgctgctgctcattttcatagtgctgtacaaggttggtttcttcaaacggaac
ctgaaggagaagatggaggctggcagaggtgtcccgaatggaatccctgcagaagactct
gagcagctggcatctgggcaagaggctggggatcccggctgcctgaagcccctccatgag
aaggactctgagagtggtggtggcaaggactga
DBGET
integrated database retrieval system
