KEGG    Network variation - Efferocytosis
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ENTRYnt06535
NameEfferocytosis
CategoryPathway view; Cellular processes
Pathwayhsa04148 Efferocytosis
Display drug-target relation   disease type
N01747    CASP3,CASP7→PANX1−(ATP,UTP,ADP,UDP)→P2Y
    OOMD7   PANX1*
    BDPLT8       P2Y12*
N01748    CASP3→PLA2G6→LPC(inner)−ABCA1→LPC(outer)→GPR132
    PARK14/NBIA2   PLA2G6*
    TGD/HPALP1       ABCA1*
N01749    CASP3,ADAM10,ADAM1..→CXCL1→CX3CR1⇒MEGF8
    AD18/RAK ADAM10*
    NISBD1 ADAM17*
    ARMD12/CHDS1     CX3CR1*
N01750    Caspase→SPHK→S1P−S1PR1→NFAT⇒HIF1⇒EPO
    JCOSL         NFATC2*
N01751    EPO→EPOR→JAK2→ERK→CEBPB⇒PPARG+RXR⇒MERTK,GAS6,MFGE8,C..
    ECYT5/MVCD2 EPO*↗
    ECYT1   EPOR*↗
    CV/AML/ECYT1     JAK2*↗
 
N01752    PtdSer(outer)−flippase+CDC50A→PtdSer(inner)
    CAMRQ4   ATP8A2*
    DFNA84/HLD24/AUNA2   ATP11A*
    HACXL   ATP11C*
 
N01753    PtdSer(inner)−scramblase→PtdSer(outer)
    BDPLT7   ANO6*
    DYT24   ANO3*
    GDD1/MMD3/LGMDR12   ANO5*
N01754    CASP3→XKR8=BSG,NPTN
 
N01761    PtdSer(outer)→MFGE8→(ITGAV+ITGB3,ITGB5..→FAK→(CAS+CRK)→(DOCK1+ELMO1)→RAC1
    GT2/BDPLT24     ITGB3*
N01762    PtdSer(outer)→(GAS6,PROS1,TIM4)→MERTK→FAK
    THPH5   PROS1*
    RP38     MERTK*
N01763    PtdSer(outer)→(C1QA,C1QB,C1QC)→MEGF10→GULP1→RAC1
    C1QD   C1QA*
    CMYP10/EMRDD     MEGF10*
 
N01764    CALR→LRP1,(C1QA,C1QB,C1..→GULP1
    MF/THCYT1 CALR*
    KPA   LRP1*
 
N01772    THBS1→CD36→MEK→ERK⇒PTGS2
    BDPLT10/CHDS7   CD36*
N01773    PTGS2→PGE2→EP2,EP4→CREB1+DNMT3A⇒TGFB1
    ASA     PTGER2*
    CF/CED/IBDIMDE         TGFB1*
N01774    SAM−DNMT3A⊣DUSP4⊣ERK
    AML/TBRS   DNMT3A*
 
N01775    MERTK→ERK⇒SERCA2⊣CAMK2
    DAR/AKV     SERCA2*
N01776    CAMK2→p38→MK2−ALOX5(cyto)→ALOX5(nuclear)
    Asthma       ALOX5*
 
N01780    CE−LIPA→Cholesterol+FA
   D1
 |
    CESD   LIPA*
N01781        Cholesterol−CH25H→25HC→LXR⇒TGFB1,ABCA1,ALOX15..
 
N01777        FA(cyto)−CPT1→FA(mt)→RISP+NADH→NAD
    MC3DN10           UQCRFS1*
N01778    NAD→SIRT1→PBX1⇒IL10
    GVHDS/RA       IL10*
 
N01779    Arg(lyso)+PQLC2→Arg(cyto)−ARG1→Orn−ODC1→Put→RAC1
    Argininemia     ARG1*
 
N01784    SGK1→SLC2A1−Glc(outer)→Glc(inner)⇉Lactate(inner)−SLC16A1→Lactate(outer)
    GLUT1DS/EIG12/SDCHCN   SLC2A1*
    MCT1D/HHF7           SLC16A1*
 
N01785    CD47→SIRPA→SHP1,SHP2
N01786    CD24→SIGLEC10→SHP1,SHP2
    MC     SHP2*

Disease nameDisease category
OOMD7H01897Oocyte/zygote/embryo maturation arrestReproductive system disease
BDPLT8H01235Bleeding disorder platelet-typeHematologic disease
PARK14/NBIA2H00057Parkinson diseaseNeurodegenerative disease
H00833Neurodegeneration with brain iron accumulationNervous system disease
TGD/HPALP1H00159Tangier diseaseInherited metabolic disorder
H00930HypoalphalipoproteinemiaInherited metabolic disorder
AD18/RAKH00056Alzheimer diseaseNeurodegenerative disease
H02665Reticulate acropigmentation of KitamuraSkin disease
NISBD1H02467Neonatal inflammatory skin and bowel diseaseImmune system disease
ARMD12/CHDS1H00821Age-related macular degenerationNervous system disease
H01742Coronary artery diseaseCardiovascular disease
JCOSLH02664Joint contracture, osteochondromas, and B-cell lymphomaCancer
ECYT5/MVCD2H00236Congenital polycythemiaHematologic disease
H02559Microvascular complications of diabetesEndocrine and metabolic disease
ECYT1H00236Congenital polycythemiaHematologic disease
CV/AML/ECYT1H00012Polycythemia veraCancer
H00003Acute myeloid leukemiaCancer
H00236Congenital polycythemiaHematologic disease
CAMRQ4H01204Cerebellar ataxia, mental retardation (MR), and dysequilibrium syndrome (CAMRQ)Nervous system disease
DFNA84/HLD24/AUNA2H00604Deafness, autosomal dominantNervous system disease
H00679Hypomyelinating leukodystrophyInherited metabolic disorder
H02339Auditory neuropathyNervous system disease
HACXLH02658X-linked congenital hemolytic anemiaHematologic disease
BDPLT7H01162Scott syndromeHematologic disease
DYT24H00831Primary dystoniaNervous system disease
GDD1/MMD3/LGMDR12H00498Gnathodiaphyseal dysplasiaMusculoskeletal disease
H01965Miyoshi muscular dystrophyNervous system disease
H00593Limb-girdle muscular dystrophyNervous system disease
GT2/BDPLT24H00226Glanzmann thrombastheniaHematologic disease
H01235Bleeding disorder platelet-typeHematologic disease
THPH5H00223Inherited thrombophiliaHematologic disease
RP38H00527Retinitis pigmentosaNervous system disease
C1QDH00102Classic complement pathway component defectsPrimary immunodeficiency
CMYP10/EMRDDH01810Congenital myopathyNervous system disease
H02321Early-onset myopathy, areflexia, respiratory distress, and dysphagiaMusculoskeletal disease
MF/THCYT1H01605MyelofibrosisCancer
H01612Essential thrombocythemiaHematologic disease
KPAH00750Keratosis pilaris atrophicansCongenital malformation
BDPLT10/CHDS7H01108CD36 deficiencyHematologic disease
H01742Coronary artery diseaseCardiovascular disease
ASAH01191Asthma with nasal polyps and aspirin intoleranceImmune system disease
CF/CED/IBDIMDEH00218Cystic fibrosisRespiratory system disease
H00434Camurati-Engelmann diseaseCongenital malformation
H02669Inflammatory bowel disease, immunodeficiency, and encephalopathyImmune system disease
AML/TBRSH00003Acute myeloid leukemiaCancer
H02294Tatton-Brown-Rahman syndromeCongenital malformation
DAR/AKVH00715Darier diseaseCongenital malformation
H00755Acrokeratosis verruciformisCongenital malformation
AsthmaH00079AsthmaImmune system disease
CESDH00148Lysosomal acid lipase deficiencyInherited metabolic disorder, Lysosomal disease
MC3DN10H02086Mitochondrial complex III deficiencyInherited metabolic disorder, Mitochondrial disease
GVHDS/RAH00084Graft-versus-host diseaseImmune system disease
H00630Rheumatoid arthritisImmune system disease
ArgininemiaH00186HyperargininemiaInherited metabolic disorder
GLUT1DS/EIG12/SDCHCNH00836GLUT1 deficiency syndromeNervous system disease
H00808Idiopathic generalized epilepsiesNervous system disease
H00232Hereditary stomatocytosisHematologic disease
MCT1D/HHF7H01248Monocarboxylate transporter 1 deficiencyInherited metabolic disorder
H01267Familial hyperinsulinemic hypoglycemiaInherited metabolic disorder
MCH01018MetachondromatosisCongenital malformation


Drug name
D1D10377Sebelipase alfa (USAN)