Homo sapiens (human): 3937 Help Entry 3937              CDS       T01001                                  Gene name LCP2, SLP-76, SLP76 Definition (RefSeq) lymphocyte cytosolic protein 2   KO K07361   lymphocyte cytosolic protein 2 Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04380   Osteoclast differentiation hsa04611   Platelet activation hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa05135   Yersinia infection Network nt06120  Calcium signaling (viruses and bacteria)   Element N01106   TCR-NFAT signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     3937 (LCP2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     3937 (LCP2)    04650 Natural killer cell mediated cytotoxicity     3937 (LCP2)    04660 T cell receptor signaling pathway     3937 (LCP2)    04664 Fc epsilon RI signaling pathway     3937 (LCP2)   09158 Development and regeneration    04380 Osteoclast differentiation     3937 (LCP2)  09160 Human Diseases   09171 Infectious disease: bacterial    05135 Yersinia infection     3937 (LCP2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  SH2 SAM_2 SAM_1 Motif Other DBs NCBI-GeneID:  3937 NCBI-ProteinID:  NP_005556 OMIM:  601603 HGNC:  6529 Ensembl:  ENSG00000043462 Vega:  OTTHUMG00000163121 Pharos:  Q13094(Tbio) UniProt:  Q13094 LinkDB All DBs Structure PDB:  2EAP Thumbnails Position 5q35.1 AA seq 533 aa AA seqDB search MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKL RVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQ DGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSG KTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTK PPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPL PGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHM PGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNE EWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKES QVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP NT seq 1602 nt NT seq  +upstreamnt  +downstreamnt atggcactgaggaatgtgccctttcgctcagaggtcctgggctgggaccccgacagcctt gctgactatttcaagaagctcaactataaggactgtgagaaggcagtgaagaagtaccac atcgatggggctcgcttcttgaacctgacagaaaatgacatccagaagttccccaagctc cgggtgccgattctcagtaagttaagtcaggaaatcaacaagaacgaagagaggaggagc atcttcacacgcaaaccccaagtcccgcggtttcctgaagagacagaaagccacgaagag gacaatgggggctggtcgtcctttgaagaagacgattatgaaagtcccaatgatgaccag gatggggaggatgatggagactatgagtcccccaatgaggaggaagaggcacccgtggaa gatgacgcggattatgagccgccaccctccaatgacgaggaagctctgcagaactccatc ctgcctgccaagcctttccccaactccaactccatgtacatcgaccggcccccctctggg aaaaccccccagcagcctcctgtgcccccccagagaccgatggccgccctcccgccccca ccagccggccggaatcactcgccactgcccccaccccagaccaaccacgaagaacccagc agaagcagaaaccacaaaacggcaaagctccctgctccttcaatagacagaagcacgaaa cctcccctagatcgttcattagctccgtttgatagagaacccttcacactaggaaagaaa ccaccattttctgacaagccctcgattccagcgggaaggtcactcggggagcatttaccc aagattcaaaagcctcctttaccaccgaccacggaaagacatgaaaggagcagccccctg ccagggaagaagccacctgtgccaaagcatggatggggaccagacagaagagagaatgat gaagatgatgtgcatcagagacctttgccccagccagcactacttcctatgagctccaac actttcccttcaagatctactaagccaagtcccatgaaccctctcccatcctctcacatg cctggagcattctcagaaagtaacagcagttttccacagagtgcctccctgccaccatac ttctctcaaggccctagcaacagaccacctatcagagccgaaggcagaaacttccccttg ccacttccaaacaaacctcggcccccatcccccgcggaggaagagaattcattaaatgaa gagtggtacgtttcttatattacccgaccagaggcagaagctgctcttagaaagataaac caggatggcacatttctggtcagagacagctctaaaaaaacaacaaccaatccatatgtc ctcatggtgttgtacaaagataaagtttacaacatccagatccgttatcagaaggaaagt caagtttacttgttgggaactggactccgagggaaagaggactttctgtctgtgtcagat attattgactacttcaggaaaatgccacttctgctcattgatgggaaaaaccgaggttcc agataccagtgcacattaacgcatgctgcagggtacccatag

Homo sapiens (human): 27040 Help Entry 27040             CDS       T01001                                  Gene name LAT, IMD52, LAT1, pp36 Definition (RefSeq) linker for activation of T cells   KO K07362   linker for activation of T cells Organism hsa  Homo sapiens (human) Pathway hsa04014   Ras signaling pathway hsa04015   Rap1 signaling pathway hsa04064   NF-kappa B signaling pathway hsa04650   Natural killer cell mediated cytotoxicity hsa04658   Th1 and Th2 cell differentiation hsa04659   Th17 cell differentiation hsa04660   T cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa05135   Yersinia infection hsa05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Network nt06120  Calcium signaling (viruses and bacteria)   Element N01106   TCR-NFAT signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     27040 (LAT)    04015 Rap1 signaling pathway     27040 (LAT)    04064 NF-kappa B signaling pathway     27040 (LAT)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     27040 (LAT)    04660 T cell receptor signaling pathway     27040 (LAT)    04658 Th1 and Th2 cell differentiation     27040 (LAT)    04659 Th17 cell differentiation     27040 (LAT)    04664 Fc epsilon RI signaling pathway     27040 (LAT)    04666 Fc gamma R-mediated phagocytosis     27040 (LAT)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     27040 (LAT)   09171 Infectious disease: bacterial    05135 Yersinia infection     27040 (LAT) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LAT Motif Other DBs NCBI-GeneID:  27040 NCBI-ProteinID:  NP_055202 OMIM:  602354 HGNC:  18874 Ensembl:  ENSG00000213658 Vega:  OTTHUMG00000131761 Pharos:  O43561(Tbio) UniProt:  O43561 A0A024QZD6 LinkDB All DBs Position 16p11.2 AA seq 262 aa AA seqDB search MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPW PPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRG AQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAP ALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALS SQEAEEVEEEGAPDYENLQELN NT seq 789 nt NT seq  +upstreamnt  +downstreamnt atggaggaggccatcctggtcccctgcgtgctggggctcctgctgctgcccatcctggcc atgttgatggcactgtgtgtgcactgccacagactgccaggctcctacgacagcacatcc tcagatagtttgtatccaaggggcatccagttcaaacggcctcacacggttgccccctgg ccacctgcctacccacctgtcacctcctacccacccctgagccagccagacctgctcccc atcccaagatccccgcagccccttgggggctcccaccggacgccatcttcccggcgggat tctgatggtgccaacagtgtggcgagctacgagaacgagggtgcgtctgggatccgaggt gcccaggctgggtggggagtctggggtccgtcctggactaggctgacccctgtgtcgtta cccccagaaccagcctgtgaggatgcggatgaggatgaggacgactatcacaacccaggc tacctggtggtgcttcctgacagcaccccggccactagcactgctgccccatcagctcct gcactcagcacccctggcatccgagacagtgccttctccatggagtccattgatgattac gtgaacgttccggagagcggggagagcgcagaagcgtctctggatggcagccgggagtat gtgaatgtgtcccaggaactgcatcctggagcggctaagactgagcctgccgccctgagt tcccaggaggcagaggaagtggaggaagagggggctccagattacgagaatctgcaggag ctgaactga

Homo sapiens (human): 7409 Help Entry 7409              CDS       T01001                                  Gene name VAV1, VAV Definition (RefSeq) vav guanine nucleotide exchange factor 1   KO K05730   guanine nucleotide exchange factor VAV Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04662   B cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05135   Yersinia infection hsa05205   Proteoglycans in cancer hsa05417   Lipid and atherosclerosis Network nt06120  Calcium signaling (viruses and bacteria)   Element N01106   TCR-NFAT signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     7409 (VAV1)    04024 cAMP signaling pathway     7409 (VAV1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7409 (VAV1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7409 (VAV1)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     7409 (VAV1)    04660 T cell receptor signaling pathway     7409 (VAV1)    04662 B cell receptor signaling pathway     7409 (VAV1)    04664 Fc epsilon RI signaling pathway     7409 (VAV1)    04666 Fc gamma R-mediated phagocytosis     7409 (VAV1)    04670 Leukocyte transendothelial migration     7409 (VAV1)    04062 Chemokine signaling pathway     7409 (VAV1)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     7409 (VAV1)   09171 Infectious disease: bacterial    05135 Yersinia infection     7409 (VAV1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     7409 (VAV1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RhoGEF SH3_1 SH3_2 CAMSAP_CH CH SH2 SH3_9 C1_1 PH CDC24 C1_2 DUF3104 LZ3wCH PH_16 Motif Other DBs NCBI-GeneID:  7409 NCBI-ProteinID:  NP_005419 OMIM:  164875 HGNC:  12657 Ensembl:  ENSG00000141968 Vega:  OTTHUMG00000181965 Pharos:  P15498(Tchem) UniProt:  P15498 Q96D37 B2R8B5 LinkDB All DBs Structure PDB:  3BJI 3KY9 2MC1 2LCT 2ROR 2CRH Thumbnails Position 19p13.3 AA seq 845 aa AA seqDB search MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED YSEYC NT seq 2538 nt NT seq  +upstreamnt  +downstreamnt atggagctgtggcgccaatgcacccactggctcatccagtgccgggtgctgccgcccagc caccgcgtgacctgggatggggctcaggtgtgtgaactggcccaggccctccgggatggt gtccttctgtgtcagctgcttaacaacctgctaccccatgccatcaacctgcgtgaggtc aacctgcgcccccagatgtcccagttcctgtgccttaagaacattagaaccttcctgtcc acctgctgtgagaagttcggcctcaagcggagcgagctcttcgaagcctttgacctcttc gatgtgcaggattttggcaaggtcatctacaccctgtctgctctgtcctggaccccgatc gcccagaacagggggatcatgcccttccccaccgaggaggagagtgtaggtgatgaagac atctacagtggcctgtccgaccagatcgacgacacggtggaggaggatgaggacctgtat gactgcgtggagaatgaggaggcggaaggcgacgagatctatgaggacctcatgcgctcg gagcccgtgtccatgccgcccaagatgacagagtatgacaagcgctgctgctgcctgcgg gagatccagcagacggaggagaagtacactgacacgctgggctccatccagcagcatttc ttgaagcccctgcaacggttcctgaaacctcaagacattgagatcatctttatcaacatt gaggacctgcttcgtgttcatactcacttcctaaaggagatgaaggaagccctgggcacc cctggcgcagccaatctctaccaggtcttcatcaaatacaaggagaggttcctcgtctat ggccgctactgcagccaggtggagtcagccagcaaacacctggaccgtgtggccgcagcc cgggaggacgtgcagatgaagctggaggaatgttctcagagagccaacaacgggaggttc accctgcgggacctgctgatggtgcctatgcagcgagttctcaaatatcacctccttctc caggagctggtgaaacacacgcaggaggcgatggagaaggagaacctgcggctggccctg gatgccatgagggacctggctcagtgcgtgaacgaggtcaagcgagacaacgagacactg cgacagatcaccaatttccagctgtccattgagaacctggaccagtctctggctcactat ggccggcccaagatcgacggggaactcaagatcacctcggtggaacggcgctccaagatg gacaggtatgccttcctgctcgacaaagctctactcatctgtaagcgcaggggagactcc tatgacctcaaggactttgtaaacctgcacagcttccaggttcgggatgactcttcagga gaccgagacaacaagaagtggagccacatgttcctcctgatcgaggaccaaggtgcccag ggctatgagctgttcttcaagacaagagaattgaagaagaagtggatggagcagtttgag atggccatctccaacatctatccggagaatgccaccgccaacgggcatgacttccagatg ttctcctttgaggagaccacatcctgcaaggcctgtcagatgctgcttagaggtaccttc tatcagggctaccgctgccatcggtgccgggcatctgcacacaaggagtgtctggggagg gtccctccatgtggccgacatgggcaagatttcccaggaactatgaagaaggacaaacta catcgcagggctcaggacaaaaagaggaatgagctgggtctgcccaagatggaggtgttt caggaatactacgggcttcctccaccccctggagccattggaccctttctacggctcaac cctggagacattgtggagctcacgaaggctgaggctgaacagaactggtgggagggcaga aatacatctactaatgaaattggctggtttccttgtaacagggtgaagccctatgtccat ggccctcctcaggacctgtctgttcatctctggtacgcaggccccatggagcgggcaggg gcagagagcatcctggccaaccgctcggacgggactttcttggtgcggcagagggtgaag gatgcagcagaatttgccatcagcattaaatataacgtcgaggtcaagcacattaaaatc atgacagcagaaggactgtaccggatcacagagaaaaaggctttccgggggcttacggag ctggtggagttttaccagcagaactctctaaaggattgcttcaagtctctggacaccacc ttgcagttccccttcaaggagcctgaaaagagaaccatcagcaggccagcagtgggaagc acaaagtattttggcacagccaaagcccgctatgacttctgcgcccgagaccgatcagag ctgtcgctcaaggagggtgacatcatcaagatccttaacaagaagggacagcaaggctgg tggcgaggggagatctatggccgggttggctggttccctgccaactacgtggaggaagat tattctgaatactgctga

Homo sapiens (human): 7410 Help Entry 7410              CDS       T01001                                  Gene name VAV2, VAV-2 Definition (RefSeq) vav guanine nucleotide exchange factor 2   KO K05730   guanine nucleotide exchange factor VAV Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04662   B cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05135   Yersinia infection hsa05205   Proteoglycans in cancer hsa05417   Lipid and atherosclerosis Network nt06120  Calcium signaling (viruses and bacteria)   Element N01106   TCR-NFAT signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     7410 (VAV2)    04024 cAMP signaling pathway     7410 (VAV2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7410 (VAV2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7410 (VAV2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     7410 (VAV2)    04660 T cell receptor signaling pathway     7410 (VAV2)    04662 B cell receptor signaling pathway     7410 (VAV2)    04664 Fc epsilon RI signaling pathway     7410 (VAV2)    04666 Fc gamma R-mediated phagocytosis     7410 (VAV2)    04670 Leukocyte transendothelial migration     7410 (VAV2)    04062 Chemokine signaling pathway     7410 (VAV2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     7410 (VAV2)   09171 Infectious disease: bacterial    05135 Yersinia infection     7410 (VAV2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     7410 (VAV2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RhoGEF CAMSAP_CH SH3_2 CH SH3_1 SH3_9 SH2 C1_1 PH CDC24 PLU-1 C1_2 PH_10 PH_16 Zn_ribbon_17 zf-RING-like Motif Other DBs NCBI-GeneID:  7410 NCBI-ProteinID:  NP_001127870 OMIM:  600428 HGNC:  12658 Ensembl:  ENSG00000160293 Vega:  OTTHUMG00000020882 Pharos:  P52735(Tbio) UniProt:  P52735 LinkDB All DBs Structure PDB:  4ROJ 2LNW 2LNX 2DLZ 2DM1 Thumbnails Position 9q34.2 AA seq 878 aa AA seqDB search MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ NT seq 2637 nt NT seq  +upstreamnt  +downstreamnt atggagcagtggcggcagtgcggccgctggctcatcgattgcaaggtcctgccgcccaac caccgggtggtgtggccctcggccgtggtcttcgacctggcgcaggcgctgcgcgacggg gtccttctgtgccagctgctgcacaacctctcccccggctccatcgacctcaaggacatc aacttccggccgcagatgtcccagtttctgtgtttgaagaacatacgcaccttcctgaaa gtctgccacgataaatttggattaaggaacagcgagctgtttgacccctttgacctcttc gatgtgcgagactttggaaaggtcatctccgcggtgtcgaggctctccctgcacagcatc gcgcagaacaaagggatcaggccttttccctcagaggagaccacagagaatgacgatgac gtctaccgcagcctggaggagctggccgacgagcatgacctgggggaggacatctacgac tgcgtcccgtgtgaggatggaggggacgacatctacgaggacatcatcaaggtggaggtg cagcagcccatgattagatacatgcagaaaatgggcatgactgaagatgacaagaggaac tgctgcctgctggagatccaggagaccgaggccaagtactaccgcaccctggaggacatt gagaagaactacatgagccccctgcggctggtgctgagcccggcggacatggcagctgtc ttcattaacctggaggacctgatcaaggtgcatcacagcttcctgagggccatcgacgtg tccgtgatggtggggggcagcacgctggccaaggtcttcctcgatttcaaggaaaggctt ctgatctacggggagtactgcagccacatggagcacgcccagaacacactgaaccagctc ctggccagccgggaggacttcaggcagaaagtcgaggagtgcacactgaaggtccaggat ggaaaatttaagctgcaagacctgctggtggtccccatgcagagggtgctcaaataccac ctgctcttgaaggagcttctgagccattctgcggaacggcctgagaggcagcagctcaaa gaagcactggaagccatgcaggacttggcgatgtacatcaatgaagttaaacgggacaag gagaccttgaggaaaatcagcgaatttcagagttctatagaaaatttgcaagtgaaactg gaggaatttggaagaccaaagattgacggggaactgaaagtccggtccatagtcaaccac accaagcaggacaggtacttgttcctgtttgacaaggtggtcatcgtctgcaagcggaag ggctacagctacgagctcaaggagatcatcgagctgctgttccacaagatgaccgacgac cccatgaacaacaaggacgtcaagaagtctcacgggaaaatgtggtcctacggcttctac ctaattcaccttcaaggaaagcagggcttccagtttttctgcaaaacagaagatatgaag aggaagtggatggagcagtttgagatggccatgtcaaacatcaagccagacaaagccaat gccaaccaccacagtttccagatgtacacgtttgacaagaccaccaactgcaaagcctgc aaaatgttcctcaggggcaccttctaccagggatacatgtgtaccaagtgtggcgtcggg gcacacaaggagtgcctggaagtgatacctccctgcaagttcacttctcctgcagatctg gacgcctccggagcgggaccaggtcccaagatggtggccatgcagaattaccatggcaac ccagcccctcccgggaagcctgtgctgaccttccagacgggcgacgtgcttgagctgctg aggggcgaccctgagtctccgtggtgggagggtcgtctggtacaaaccaggaagtcaggg tatttccccagctcatctgtgaagccctgccctgtggatggaaggccgcccatcagccgg ccgccatcccgggagatcgactacactgcatacccctggtttgcaggtaacatggagagg cagcagacggacaacctgctcaagtcccacgccagcgggacctacctgatcagggagcgg cctgccgaggctgagcgctttgcaataagcatcaagttcaatgatgaggtgaagcacatc aaggtggtggagaaggacaactggatccacatcacagaggccaagaaattcgacagcctc ctggagttggtggagtactaccagtgccactcactgaaggagagcttcaagcagctggac accacactcaagtacccctacaagtcccgggaacgttcggcctccagggcctccagccgg tccccagcttcctgtgcttcctacaacttttcttttctcagtcctcagggcctcagcttt gcttctcagggcccctccgctcccttctggtcagtgttcacgccccgcgtcatcggcaca gctgtggccaggtataactttgccgcccgagatatgagggagctttcgctgcgggagggt gacgtggtgaggatctacagccgcatcggcggagaccagggctggtggaagggcgagacc aacggacggattggctggtttccttcaacgtacgtagaagaggagggcatccagtga

Homo sapiens (human): 10451 Help Entry 10451             CDS       T01001                                  Gene name VAV3 Definition (RefSeq) vav guanine nucleotide exchange factor 3   KO K05730   guanine nucleotide exchange factor VAV Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04662   B cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05135   Yersinia infection hsa05205   Proteoglycans in cancer hsa05417   Lipid and atherosclerosis Network nt06120  Calcium signaling (viruses and bacteria)   Element N01106   TCR-NFAT signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     10451 (VAV3)    04024 cAMP signaling pathway     10451 (VAV3)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     10451 (VAV3)   09142 Cell motility    04810 Regulation of actin cytoskeleton     10451 (VAV3)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     10451 (VAV3)    04660 T cell receptor signaling pathway     10451 (VAV3)    04662 B cell receptor signaling pathway     10451 (VAV3)    04664 Fc epsilon RI signaling pathway     10451 (VAV3)    04666 Fc gamma R-mediated phagocytosis     10451 (VAV3)    04670 Leukocyte transendothelial migration     10451 (VAV3)    04062 Chemokine signaling pathway     10451 (VAV3)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     10451 (VAV3)   09171 Infectious disease: bacterial    05135 Yersinia infection     10451 (VAV3)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     10451 (VAV3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RhoGEF SH3_2 CAMSAP_CH CH SH3_1 SH3_9 SH2 C1_1 PH CDC24 Filamin PH_16 PH_10 LZ3wCH Prok-RING_1 Zn_ribbon_17 C1_2 zf-RING-like Motif Other DBs NCBI-GeneID:  10451 NCBI-ProteinID:  NP_006104 OMIM:  605541 HGNC:  12659 Ensembl:  ENSG00000134215 Vega:  OTTHUMG00000010995 Pharos:  Q9UKW4(Tbio) UniProt:  Q9UKW4 LinkDB All DBs Structure PDB:  2D86 Thumbnails Position 1p13.3 AA seq 847 aa AA seqDB search MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS TYVEEDE NT seq 2544 nt NT seq  +upstreamnt  +downstreamnt atggagccgtggaagcagtgcgcgcagtggctcatccattgcaaggtgctgcccaccaac caccgggtgacctgggactcggctcaggtgttcgaccttgcgcagaccctccgcgatgga gtcctgctctgccagctgcttaacaacctccgggcgcactccatcaacctgaaggagatc aacctgaggccgcagatgtcccagtttctctgtttgaagaacataaggacatttctcacg gcctgttgtgagacgtttggaatgaggaaaagtgaacttttcgaggcatttgacttgttt gatgttcgtgactttggaaaggttatagaaacattatcacgactttctcgaacacctata gcattggccacaggaatcaggcccttcccaacagaagaaagcattaatgatgaagacatc tacaaaggccttcctgatttaatagatgaaacccttgtggaagatgaagaagatctctat gactgtgtttatggggaagatgaaggtggagaagtctatgaggacttaatgaaggcagag gaagcacatcagcccaaatgtccagaaaatgatatacgaagttgttgtctagcagaaatt aagcagacagaagaaaaatatacagaaactttggagtcaatagaaaagtatttcatggca ccactaaaaagatttctgacagcagcagaatttgattcagtattcatcaacattcctgaa cttgtaaaacttcatcggaacctaatgcaagagattcatgattccattgtaaataaaaat gaccagaacttgtaccaagtttttattaactacaaggaaagattggttatttacgggcag tactgcagtggagtggagtcagccatctctagtttagactacatttctaagacaaaagaa gatgtcaaactgaaattagaggaatgttccaaaagagcaaataatgggaaatttactctt cgagacttgcttgtggttcctatgcaacgtgttttaaagtaccaccttctcctccaggaa ctggtcaaacataccactgatccgactgagaaggcaaatctgaaactggctcttgatgcc atgaaggacttggcacaatatgtgaatgaagtgaaaagagataatgagacccttcgtgaa attaaacagtttcagctatctatagagaatttgaaccaaccagttttgctttttggacga cctcagggagatggtgaaattcgaataaccactctagacaagcataccaaacaagaaagg catatcttcttatttgatttggcagtgatcgtatgtaagagaaaaggtgataactatgaa atgaaggaaataatagatcttcagcagtacaagatagccaataatcctacaaccgataaa gaaaacaaaaagtggtcttatggcttctacctcatccatacccaaggacaaaatgggtta gaattttattgcaaaacaaaagatttaaagaagaaatggctagaacagtttgaaatggct ttgtctaacataagaccagactatgcagactccaatttccacgacttcaagatgcatacc ttcactcgagtcacatcctgcaaagtctgccagatgctcctgaggggaacattttatcaa ggctatttatgttttaagtgtggagcgagagcacacaaagaatgtttgggaagagtagac aattgtggcagagttaattctggtgaacaagggacactcaaactaccagagaaacggacc aatggactgcgaagaactcctaaacaggtggatccaggtttaccaaagatgcaggtcatt aggaactattctggaacaccacccccagctctgcatgaaggaccccctttacagctccag gccggggataccgttgaacttctgaaaggagatgcacacagtctgttttggcagggcaga aatttagcatctggagaggttggattttttccaagtgatgcagtcaagccttgcccatgt gtgcccaaaccagtagattattcttgccaaccctggtatgctggagcaatggaaagattg caagcagagaccgaacttattaatagggtaaatagtacttaccttgtgaggcacaggacc aaagagtcaggagaatatgcaattagcattaagtacaataatgaagcaaagcacatcaag attttaacaagagatggcttttttcacattgcagaaaatagaaaatttaaaagtttaatg gaacttgtggagtactacaagcatcattctctcaaggaagggttcagaaccttagataca actctgcagtttccatacaaggagccagaacattcagctggacagaggggtaatagagca ggcaacagcttgttaagtccaaaagtgctgggcattgccatcgctcggtatgacttctgt gcaagagatatgagagagttgtccttgttgaaaggagatgtggtgaagatttacacaaag atgagtgcaaatggctggtggagaggagaagtaaatggcagggtgggctggtttccatcc acatatgtggaagaggatgaataa

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