Homo sapiens (human): 3949 Help Entry 3949              CDS       T01001                                  Symbol LDLR, FH, FHC, FHCL1, LDLCQ2 Name (RefSeq) low density lipoprotein receptor   KO K12473   low-density lipoprotein receptor Organism hsa  Homo sapiens (human) Pathway hsa04144   Endocytosis hsa04913   Ovarian steroidogenesis hsa04925   Aldosterone synthesis and secretion hsa04927   Cortisol synthesis and secretion hsa04934   Cushing syndrome hsa04976   Bile secretion hsa04979   Cholesterol metabolism hsa05145   Toxoplasmosis hsa05160   Hepatitis C hsa05417   Lipid and atherosclerosis Network nt06320  APOB-LDLR signaling   Element N00332   Vesicular uptake of lipoproteins N00336   PCSK9-mediated LDLR degradation Disease H00155   Familial hypercholesterolemia H01383   Hyperlipoproteinemia type IIa H01635   Hyperlipidemia H02505   Atherosclerosis Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     3949 (LDLR)  09150 Organismal Systems   09152 Endocrine system    04913 Ovarian steroidogenesis     3949 (LDLR)    04925 Aldosterone synthesis and secretion     3949 (LDLR)    04927 Cortisol synthesis and secretion     3949 (LDLR)   09154 Digestive system    04976 Bile secretion     3949 (LDLR)    04979 Cholesterol metabolism     3949 (LDLR)  09160 Human Diseases   09172 Infectious disease: viral    05160 Hepatitis C     3949 (LDLR)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     3949 (LDLR)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     3949 (LDLR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     3949 (LDLR)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hsa04131]     3949 (LDLR) Membrane trafficking [BR:hsa04131]  Endocytosis   Clathrin-mediated endocytosis    Low-density lipoprotein receptor (LDLR) family proteins     3949 (LDLR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Ldl_recept_a Ldl_recept_b FXa_inhibition cEGF EGF_CA SGL EGF hEGF Gag_p24 Motif Other DBs NCBI-GeneID:  3949 NCBI-ProteinID:  NP_000518 OMIM:  606945 HGNC:  6547 Ensembl:  ENSG00000130164 UniProt:  P01130 A0A024R7D5 Structure PDB LinkDB All DBs Position 19:11089463..11133820 Genome browser AA seq 860 aa AA seqDB search MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH NQDGYSYPSRQMVSLEDDVA NT seq 2583 nt NT seq  +upstreamnt  +downstreamnt atggggccctggggctggaaattgcgctggaccgtcgccttgctcctcgccgcggcgggg actgcagtgggcgacagatgcgaaagaaacgagttccagtgccaagacgggaaatgcatc tcctacaagtgggtctgcgatggcagcgctgagtgccaggatggctctgatgagtcccag gagacgtgcttgtctgtcacctgcaaatccggggacttcagctgtgggggccgtgtcaac cgctgcattcctcagttctggaggtgcgatggccaagtggactgcgacaacggctcagac gagcaaggctgtccccccaagacgtgctcccaggacgagtttcgctgccacgatgggaag tgcatctctcggcagttcgtctgtgactcagaccgggactgcttggacggctcagacgag gcctcctgcccggtgctcacctgtggtcccgccagcttccagtgcaacagctccacctgc atcccccagctgtgggcctgcgacaacgaccccgactgcgaagatggctcggatgagtgg ccgcagcgctgtaggggtctttacgtgttccaaggggacagtagcccctgctcggccttc gagttccactgcctaagtggcgagtgcatccactccagctggcgctgtgatggtggcccc gactgcaaggacaaatctgacgaggaaaactgcgctgtggccacctgtcgccctgacgaa ttccagtgctctgatggaaactgcatccatggcagccggcagtgtgaccgggaatatgac tgcaaggacatgagcgatgaagttggctgcgttaatgtgacactctgcgagggacccaac aagttcaagtgtcacagcggcgaatgcatcaccctggacaaagtctgcaacatggctaga gactgccgggactggtcagatgaacccatcaaagagtgcgggaccaacgaatgcttggac aacaacggcggctgttcccacgtctgcaatgaccttaagatcggctacgagtgcctgtgc cccgacggcttccagctggtggcccagcgaagatgcgaagatatcgatgagtgtcaggat cccgacacctgcagccagctctgcgtgaacctggagggtggctacaagtgccagtgtgag gaaggcttccagctggacccccacacgaaggcctgcaaggctgtgggctccatcgcctac ctcttcttcaccaaccggcacgaggtcaggaagatgacgctggaccggagcgagtacacc agcctcatccccaacctgaggaacgtggtcgctctggacacggaggtggccagcaataga atctactggtctgacctgtcccagagaatgatctgcagcacccagcttgacagagcccac ggcgtctcttcctatgacaccgtcatcagcagagacatccaggcccccgacgggctggct gtggactggatccacagcaacatctactggaccgactctgtcctgggcactgtctctgtt gcggataccaagggcgtgaagaggaaaacgttattcagggagaacggctccaagccaagg gccatcgtggtggatcctgttcatggcttcatgtactggactgactggggaactcccgcc aagatcaagaaagggggcctgaatggtgtggacatctactcgctggtgactgaaaacatt cagtggcccaatggcatcaccctagatctcctcagtggccgcctctactgggttgactcc aaacttcactccatctcaagcatcgatgtcaacgggggcaaccggaagaccatcttggag gatgaaaagaggctggcccaccccttctccttggccgtctttgaggacaaagtattttgg acagatatcatcaacgaagccattttcagtgccaaccgcctcacaggttccgatgtcaac ttgttggctgaaaacctactgtccccagaggatatggttctcttccacaacctcacccag ccaagaggagtgaactggtgtgagaggaccaccctgagcaatggcggctgccagtatctg tgcctccctgccccgcagatcaacccccactcgcccaagtttacctgcgcctgcccggac ggcatgctgctggccagggacatgaggagctgcctcacagaggctgaggctgcagtggcc acccaggagacatccaccgtcaggctaaaggtcagctccacagccgtaaggacacagcac acaaccacccgacctgttcccgacacctcccggctgcctggggccacccctgggctcacc acggtggagatagtgacaatgtctcaccaagctctgggcgacgttgctggcagaggaaat gagaagaagcccagtagcgtgagggctctgtccattgtcctccccatcgtgctcctcgtc ttcctttgcctgggggtcttccttctatggaagaactggcggcttaagaacatcaacagc atcaactttgacaaccccgtctatcagaagaccacagaggatgaggtccacatttgccac aaccaggacggctacagctacccctcgagacagatggtcagtctggaggatgacgtggcg tga

DBGET integrated database retrieval system