KEGG ORTHOLOGY: K12473

ORTHOLOGY: K12473

Entry

K12473                      KO

Symbol

LDLR

Name

low-density lipoprotein receptor

Pathway

map03272

Virion - Hepatitis viruses

map04144

Endocytosis

map04913

Ovarian steroidogenesis

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

map04976

Bile secretion

map04979

Cholesterol metabolism

map05145

Toxoplasmosis

map05160

Hepatitis C

map05417

Lipid and atherosclerosis

Disease

H00155

Familial hypercholesterolemia

H01383

Hyperlipoproteinemia type IIa

H01635

Hyperlipidemia

H02505

Atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    K12473  LDLR; low-density lipoprotein receptor
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K12473  LDLR; low-density lipoprotein receptor
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K12473  LDLR; low-density lipoprotein receptor
   04925 Aldosterone synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
   04927 Cortisol synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
  09154 Digestive system
   04976 Bile secretion
    K12473  LDLR; low-density lipoprotein receptor
   04979 Cholesterol metabolism
    K12473  LDLR; low-density lipoprotein receptor
09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K12473  LDLR; low-density lipoprotein receptor
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K12473  LDLR; low-density lipoprotein receptor
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K12473  LDLR; low-density lipoprotein receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K12473  LDLR; low-density lipoprotein receptor
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12473  LDLR; low-density lipoprotein receptor
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    K12473  LDLR; low-density lipoprotein receptor

Other DBs

GO:

0005041

Genes

HSA:	3949(LDLR)

PTR:	455722(LDLR)

PPS:	100974202(LDLR)

GGO:	101124590(LDLR)

PON:	100447659(LDLR)

PPYG:

129020095(LDLR)

NLE:	100591481(LDLR)

HMH:	116478469(LDLR)

SSYN:

129460541(LDLR)

MCC:	574283(LDLR)

MCF:	102127361(LDLR)

MTHB:

126942505

MNI:	105486920(LDLR)

CSAB:

103234364(LDLR)

CATY:

105571287(LDLR)

PANU:

101016912(LDLR)

TGE:	112612219(LDLR)

MLEU:

105549976(LDLR)

RRO:	104670517(LDLR)

RBB:	108527932(LDLR)

TFN:	117076836(LDLR)

PTEH:

111527714(LDLR)

CANG:

105520939(LDLR)

CJC:	100385319(LDLR)

SBQ:	101052112(LDLR)

CIMI:

108282022(LDLR)

ANAN:

105705784(LDLR)

CSYR:

103271413(LDLR)

MMUR:

105885441(LDLR)

LCAT:

123634498(LDLR)

PCOQ:

105807852(LDLR)

OGA:	100961250(LDLR)

MMU:	16835(Ldlr)

MCAL:

110301054(Ldlr)

MPAH:

110327206(Ldlr)

RNO:	300438(Ldlr)

MCOC:

116072569(Ldlr)

ANU:	117713690(Ldlr)

MUN:	110552462(Ldlr)

CGE:	100689399(Ldlr)

MAUA:

101828208(Ldlr)

PROB:

127231291(Ldlr)

PLEU:

114695236(Ldlr)

MORG:

121451746(Ldlr)

MFOT:

126490519

AAMP:

119809008(Ldlr)

NGI:	103734567(Ldlr)

HGL:	101703463(Ldlr)

CPOC:

100724238(Ldlr)

CCAN:

109692527(Ldlr)

DORD:

105999060(Ldlr)

DSP:	122119822(Ldlr)

PLOP:

125348726(Ldlr)

NCAR:

124968885

MMMA:

107145197(Ldlr)

OCU:	100009086(LDLR)

OPI:	101522903(LDLR)

TUP:	102484417(LDLR)

GVR:	103591348(LDLR)

CFA:	100683160(LDLR)

CLUD:

112666525(LDLR)

VVP:	112908094(LDLR)

VLG:	121495036(LDLR)

NPO:	129521725(LDLR)

AML:	100473450(LDLR)

UMR:	103678713(LDLR)

UAH:	113243010(LDLR)

UAR:	123777712(LDLR)

ELK:

111162438

LLV:

125084611

MPUF:

101671487(LDLR)

MNP:	132010994(LDLR)

MLK:	131823540(LDLR)

NVS:	122909717(LDLR)

ORO:	101367933(LDLR)

EJU:	114197654(LDLR)

ZCA:	113917152(LDLR)

MLX:	118005983(LDLR)

NSU:	110593753(LDLR)

LWW:	102726532(LDLR)

FCA:	101080362(LDLR)

PYU:	121013997(LDLR)

PCOO:

112852277(LDLR)

PBG:	122486884(LDLR)

PVIV:

125160845(LDLR)

LRUF:

124524451

PTG:	102949981(LDLR)

PPAD:

109254084(LDLR)

PUC:

125928994

AJU:

106983922

HHV:	120244466(LDLR)

BTA:	281276(LDLR)

BOM:	102268224(LDLR)

BIU:	109561609(LDLR)

BBUB:

102391004(LDLR)

BBIS:

104979804(LDLR)

CHX:	102186579(LDLR)

OAS:	443535(LDLR)

BTAX:

128050700(LDLR)

ODA:	120863950(LDLR)

CCAD:

122440398(LDLR)

MBEZ:

129558071(LDLR)

SSC:	396801(LDLR)

CFR:	102506814(LDLR)

CBAI:

105078333(LDLR)

CDK:	105087617(LDLR)

VPC:	102533667(LDLR)

BACU:

103002602(LDLR)

BMUS:

118892230(LDLR)

LVE:	103088391(LDLR)

OOR:	101283356(LDLR)

DLE:	111165995(LDLR)

PCAD:

102984457(LDLR)

PSIU:

116750909(LDLR)

NASI:

112400246(LDLR)

ECB:	100057389(LDLR)

EPZ:	103564902(LDLR)

EAI:	106846613(LDLR)

MYB:	102246709(LDLR)

MYD:	102771350(LDLR)

MMYO:

118658815(LDLR)

MLF:	102432506(LDLR)

MDT:	132235040(LDLR)

PKL:	118731453(LDLR)

EFUS:

103301164(LDLR)

MNA:	107533280(LDLR)

DRO:	112301407(LDLR)

AJM:	119038836(LDLR)

PDIC:

114503660(LDLR)

PHAS:

123828240(LDLR)

MMF:	118615655(LDLR)

PPAM:

129061362(LDLR)

HAI:	109391592(LDLR)

RFQ:	117037787(LDLR)

PALE:

102888790(LDLR)

PGIG:

120610833(LDLR)

PVP:	105305615(LDLR)

RAY:	107515081(LDLR)

MJV:	108398211(LDLR)

TOD:	119240964(LDLR)

SARA:

101552750(LDLR)

SETR:

126030169(LDLR)

LAV:	100669109(LDLR)

TMU:

101342003

ETF:	101646129(LDLR)

DNM:	101411649(LDLR)

MDO:	654363(LDLR)

GAS:	123242434(LDLR)

SHR:	100923750(LDLR)

AFZ:

127544754

PCW:	110214144(LDLR)

TVP:	118843539(LDLR)

OAA:	100079454(LDLR)

ACYG:

125181563(LDLR)

CATA:

118261515

TGU:	115491721(LDLR)

OMA:

130263035

MMEA:

130586278

SHAB:

115603576

ACHC:

115348083(LDLR)

AGEN:

126043050

ASN:	102370878(LDLR)

AMJ:	102574674(LDLR)

CMY:	102937401(LDLR)

CCAY:

125627557(LDLR)

DCC:	119845849(LDLR)

CPIC:

101932535(LDLR)

TST:	117888675(LDLR)

CABI:

116824825(LDLR)

MRV:	120391077(LDLR)

ACS:	100554150(ldlr)

ASAO:

132768007(LDLR)

PVT:	110077953(LDLR)

SUND:

121920600(LDLR)

PBI:	103053965(LDLR)

PMUR:

107287119(LDLR)

CTIG:

120305085(LDLR)

TSR:	106556718(LDLR)

PGUT:

117677541(LDLR)

APRI:

131190825(LDLR)

PTEX:

113446918(LDLR)

NSS:	113419970(LDLR)

VKO:	123019423(LDLR)

PMUA:

114587524(LDLR)

PRAF:

128404740(LDLR)

ZVI:	118097714(LDLR)

HCG:	128345297(LDLR)

GJA:	107105423(LDLR)

STOW:

125429179(LDLR)

EMC:	129346023(LDLR)

XLA:	373644(ldlr.S) 397757(ldlr.L)

XTR:	100495826(ldlr)

NPR:	108798866(LDLR)

RTEM:

120933319(LDLR)

BBUF:

120986415(LDLR)

BGAR:

122927204(LDLR)

MUO:	115466042(LDLR)

GSH:	117350266(LDLR)

DRE:	387529(ldlra)

SRX:	107705878 107728491(ldlr) 107743998 107758126

SANH:

107658701 107666656 107694575 107703887(ldlr)

SGH:	107568242(ldlr) 107568383

CCAR:

109059958 109063875 109091286

CAUA:

113046672 113051942 113072329 113090206

CGIB:

127945080 127951980

PTET:

122341672(ldlra)

LROH:

127155434(ldlra)

OMC:

131536059

PPRM:

120467911(ldlrb) 120489183

RKG:	130105725(ldlra)

MAMB:

125247578(ldlra) 125274052(ldlrb)

CIDE:

127508081

CERY:

137017349

MASI:

127450015 127451742

TROS:

130561616(ldlra)

TDW:	130426019(ldlra)

MANU:

129436506(ldlra)

IPU:	108273208(ldlrb) 108278865(ldlra)

IFU:	128599541(ldlra) 128615870(ldlrb)

PHYP:

113527861(ldlr) 113538289

SMEO:

124396571(ldlra) 124403629(ldlrb)

TFD:	113634480(ldlrb) 113639611(ldlra)

TVC:	132844890(ldlrb) 132860909(ldlra)

TRN:	134316543(ldlrb) 134335796(ldlra)

AMEX:

103022705(ldlra) 103043840(ldlrb)

CMAO:

118807908(ldlrb) 118821516(ldlra)

EEE:	113573232 113579405

CHAR:

105898779(ldlra) 105910160(ldlrb)

TRU:	101072134(ldlr)

TFS:	130526781(ldlrb)

TNG:	GSTEN00007886G001

LCO:	104926679 104932223

NCC:	104943331(ldlr)

TBEN:

117480011(ldlra) 117481637(ldlrb)

CGOB:

115011422 115012519(ldlr)

PGEO:

117444886 117446187(ldlrb)

GACU:

117537967(ldlrb) 117543146(ldlra)

EMAC:

134864802(ldlrb) 134877896(ldlra)

ELY:	117255578(ldlrb) 117268821(ldlra)

EFO:	125879063(ldlra) 125885721(ldlrb)

PLEP:

121941881(ldlrb) 121956263(ldlra)

SLUC:

116040497(ldlrb) 116065316(ldlra)

ECRA:

117951346(ldlrb) 117958244(ldlra)

ESP:	116694965 116702263

PFLV:

114569597(ldlr) 114569648

GAT:	120825223(ldlrb) 120828278(ldlra)

PPUG:

119218472(ldlrb) 119219920(ldlra)

AFB:	129095220(ldlrb) 129097931(ldlra)

CLUM:

117731396(ldlrb) 117735286(ldlra)

PSWI:

130188801(ldlra) 130190505(ldlrb)

MSAM:

119883456(ldlra) 119899188(ldlrb)

SCHU:

122869435(ldlra) 122872853(ldlrb)

CUD:	121503365(ldlra) 121508634(ldlrb)

ALAT:

119014578(ldlra) 119025068(ldlrb)

MZE:	101464283 101484625(ldlr) 106675973

ONL:	100711286(ldlr) 100711575

OAU:	116321393(ldlrb) 116326860(ldlra)

OLA:	100125501 101156979 101157458 101161779 101166361 101170487

OML:	112146091(ldlra) 112157423(ldlrb)

CSAI:

133421452(ldlra) 133428759(ldlrb)

XMA:	102236051 102238173(ldlr)

XCO:	114143993 114159915(ldlr)

XHE:	116720159 116735825(ldlr)

PRET:

103468275 103468516(ldlr)

PFOR:

103137717 103143695(ldlr)

PLAI:

106954811(ldlr) 106959286

PMEI:

106914624 106927660(ldlr)

GAF:	122822093(ldlra) 122830044(ldlrb)

PPRL:

129363436(ldlra)

CVG:	107080755 107082788

CTUL:

119786850(ldlra) 119788236(ldlrb)

GMU:	124862759 124863881 124869091(ldlrb)

NFU:	107376229(ldlr) 107382301

KMR:	108236227(ldlra) 108244362(ldlrb)

ALIM:

106515245 106517861(ldlr) 106535174

NWH:	119407592(ldlrb) 119421499(ldlra)

AOCE:

111566387(ldlr) 111570157

MCEP:

124997883(ldlra) 125004322(ldlrb)

CSEM:

103383992 103393733

POV:	109627633 109643259(ldlr) 109645966

SSEN:

122771337 122785707(ldlra)

HHIP:

117760340(ldlrb) 117766491(ldlra)

HSP:	118123702(ldlra) 118125515(ldlrb)

PPLT:

128436706(ldlrb) 128458711(ldlra)

SMAU:

118288551(ldlra) 118312196(ldlrb)

LCF:	108875926(ldlrb) 108898678

SDU:	111231510 111238052(ldlr)

SLAL:

111664553 111673794(ldlr)

XGL:	120786685(ldlra) 120800441(ldlrb)

HCQ:	109508411(ldlr) 109511383

SSCV:

125969213 125984104

SBIA:

133506224(ldlrb) 133514832(ldlra)

PEE:	133403698(ldlrb) 133414476(ldlra)

PTAO:

133465659(ldlra) 133477114(ldlrb)

BPEC:

110171504(ldlr) 110172564

MALB:

109958485 109973478

BSPL:

114859075(ldlrb) 114860155(ldlra)

SJO:	128368322(ldlrb) 128379153(ldlra)

SASA:

106564497 106590115 106601326 106607045

STRU:

115147372 115171355 115178268 115201570

OTW:	112230198 112234511 112247004

OMY:	100135849 110485635 110485636 110538486

OGO:	123998650 124015623 124016185

ONE:	115110608 115110609

OKI:	109865323 109883088 109886714 109893512

OKE:	118365561 118384659 127919499

SALP:

111981132 112069617

SNH:	120032515(ldlrb) 120034148 120038853

CCLU:

121551043 121553824(ldlrb) 121569456

ELS:	105012136 105013183(ldlr)

SFM:	108926163(ldlr) 108940142

PKI:	111833450 111856344(ldlr)

AANG:

118217039 118221621(ldlrb)

LOC:	102688974(ldlr)

PSPA:

121309152

ARUT:

117402032 117966839

PSEX:

120541191

LCM:	102359035(LDLR)

CMK:	103187554(ldlra)

RTP:	109924140(ldlra)

CPLA:

122552209(ldlra)

HOC:	132836051(ldlra)

LERI:

129714498(ldlra)

SOY:

TPAL:

PTRU:

HRF:

PMAX:

Reference

PMID:24447298

Authors

Martinez-Olivan J, Arias-Moreno X, Velazquez-Campoy A, Millet O, Sancho J

Title

LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.

Journal

FEBS J 281:1534-46 (2014)
DOI:10.1111/febs.12721

Sequence

[hsa:3949]

Reference

PMID:8466528

Authors

Hoffer MJ, van Eck MM, Petrij F, van der Zee A, de Wit E, Meijer D, Grosveld G, Havekes LM, Hofker MH, Frants RR

Title

The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.

Journal

Biochem Biophys Res Commun 191:880-6 (1993)
DOI:10.1006/bbrc.1993.1299

Sequence

[mmu:16835]

LinkDB

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