KEGG   Homo sapiens (human): 4293
Entry
4293              CDS       T01001                                 
Symbol
MAP3K9, MEKK9, MLK1, PRKE1
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 9
  KO
K04417  mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4293 (MAP3K9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4293 (MAP3K9)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4293 (MAP3K9)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   4293 (MAP3K9)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr SH3_9 SH3_2 SH3_1 ABC1 Pkinase_fungal OmpH GvpL_GvpF
Other DBs
NCBI-GeneID: 4293
NCBI-ProteinID: NP_001271159
OMIM: 600136
HGNC: 6861
Ensembl: ENSG00000006432
UniProt: P80192 Q8NEB1
Structure
LinkDB
Position
14:complement(70722526..70809513)
AA seq 1104 aa
MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP
RSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEE
PTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPL
EEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSI
SECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH
VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPR
LPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSP
ANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDST
VPLCRAELNTHRPAPYEIQQEFWS
NT seq 3315 nt   +upstreamnt  +downstreamnt
atggagccctccagagcgcttctcggctgcctagcgagcgccgccgctgccgccccgccg
ggggaggatggagcaggggccggggccgaggaggaggaggaggaggaggaggaggcggcg
gcggcggtgggccccggggagctgggctgcgacgcgccgctgccctactggacggccgtg
ttcgagtacgaggcggcgggcgaggacgagctgaccctgcggctgggcgacgtggtggag
gtgctgtccaaggactcgcaggtgtccggcgacgagggctggtggaccgggcagctgaac
cagcgggtgggcatcttccccagcaactacgtgaccccgcgcagcgccttctccagccgc
tgccagcccggcggcgaggaccccagttgctacccgcccattcagttgttagaaattgat
tttgcggagctcaccttggaagagattattggcatcgggggctttgggaaggtctatcgt
gctttctggataggggatgaggttgctgtgaaagcagctcgccacgaccctgatgaggac
atcagccagaccatagagaatgttcgccaagaggccaagctcttcgccatgctgaagcac
cccaacatcattgccctaagaggggtatgtctgaaggagcccaacctctgcttggtcatg
gagtttgctcgtggaggacctttgaatagagtgttatctgggaaaaggattcccccagac
atcctggtgaattgggctgtgcagattgccagagggatgaactacttacatgatgaggca
attgttcccatcatccaccgcgaccttaagtccagcaacatattgatcctccagaaggtg
gagaatggagacctgagcaacaagattctgaagatcactgattttggcctggctcgggaa
tggcaccgaaccaccaagatgagtgcggcagggacgtatgcttggatggcacccgaagtc
atccgggcctccatgttttccaaaggcagtgatgtgtggagctatggggtgctactttgg
gagttgctgactggtgaggtgccctttcgaggcattgatggcttagcagtcgcttatgga
gtggccatgaacaaactcgcccttcctattccttctacgtgcccagaaccttttgccaaa
ctcatggaagactgctggaatcctgatccccactcacgaccatctttcacgaatatcctg
gaccagctaaccaccatagaggagtctggtttctttgaaatgcccaaggactccttccac
tgcctgcaggacaactggaaacacgagattcaggagatgtttgaccaactcagggccaaa
gaaaaggaacttcgcacctgggaggaggagctgacgcgggctgcactgcagcagaagaac
caggaggaactgctgcggcgtcgggagcaggagctggccgagcgggagattgacatcctg
gaacgggagctcaacatcatcatccaccagctgtgccaggagaagccccgggtgaagaaa
cgcaagggcaagttcaggaagagccggctgaagctcaaggatggcaaccgcatcagcctc
ccttctgatttccagcacaagttcacggtgcaggcctcccctaccatggataaaaggaag
agtcttatcaacagccgctccagtcctcctgcaagccccaccatcattcctcgccttcga
gccatccagttgacaccaggtgaaagcagcaaaacctggggcaggagctcagtcgtccca
aaggaggaaggggaggaggaggagaagagggccccaaagaagaagggacggacgtggggg
ccagggacgcttggtcagaaggagcttgcctcgggagatgaaggatcccctcagagacgt
gagaaagctaatggtttaagtaccccatcagaatctccacatttccacttgggcctcaag
tccctggtagatggatataagcagtggtcgtccagtgcccccaacctggtgaagggccca
aggagtagcccggccctgccagggttcaccagccttatggagatggaggatgaggacagt
gaaggcccagggagtggagagagtcgcctacagcattcacccagccagtcctacctctgt
atcccattccctcgtggagaggatggcgatggcccctccagtgatggaatccatgaggag
cccaccccagtcaactcggccacgagtacccctcagctgacgccaaccaacagcctcaag
cggggcggtgcccaccaccgccgctgcgaggtggctctgctcggctgtggggctgttctg
gcagccacaggcctagggtttgacttgctggaagctggcaagtgccagctgcttcccctg
gaggagcctgagccaccagcccgggaggagaagaaaagacgggagggtctttttcagagg
tccagccgtcctcgtcggagcaccagccccccatcccgaaagcttttcaagaaggaggag
cccatgctgttgctaggagacccctctgcctccctgacgctgctctccctctcctccatc
tccgagtgcaactccacacgctccctgctgcgctccgacagcgatgaaattgtcgtgtat
gagatgccagtcagcccagtcgaggcccctcccctgagtccatgtacccacaaccccctg
gtcaatgtccgagtagagcgcttcaaacgagatcctaaccaatctctgactcccacccat
gtcaccctcaccaccccctcgcagcccagcagtcaccggcggactccttctgatggggcc
cttaagccagagactctcctagccagcaggagcccctccagcaatgggttgagccccagt
cctggagcaggaatgttgaaaacccccagtcccagccgagacccaggtgaattcccccgt
ctccctgaccccaatgtggtcttccccccaaccccaaggcgctggaacactcagcaggac
tctaccttggagagacccaagactctggagtttctgcctcggccgcgtccttctgccaac
cggcaacggctggacccttggtggtttgtgtcccccagccatgcccgcagcacctcccca
gccaacagctccagcacagagacgcccagcaacctggactcctgctttgctagcagtagc
agcactgtagaggagcggcctggacttccagccctgctcccgttccaggcagggccgctg
cccccgactgagcggacgctcctggacctggatgcagaggggcagagtcaggacagcacc
gtgccgctgtgcagagcggaactgaacacacacaggcctgccccttatgagatccagcag
gagttctggtcttag

KEGG   Homo sapiens (human): 4294
Entry
4294              CDS       T01001                                 
Symbol
MAP3K10, MEKK10, MLK2, MST
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 10
  KO
K04418  mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06461  Huntington disease
nt06526  MAPK signaling
  Element
N00992  Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4294 (MAP3K10)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    4294 (MAP3K10)
   05022 Pathways of neurodegeneration - multiple diseases
    4294 (MAP3K10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4294 (MAP3K10)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4294 (MAP3K10)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   4294 (MAP3K10)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 Pkinase_fungal RNase_Y_N OmpH
Other DBs
NCBI-GeneID: 4294
NCBI-ProteinID: NP_002437
OMIM: 600137
HGNC: 6849
Ensembl: ENSG00000130758
UniProt: Q02779
Structure
LinkDB
Position
19:40191426..40215575
AA seq 954 aa
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE
EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR
GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT
PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP
ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG
LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP
PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP
EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK
LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
NT seq 2865 nt   +upstreamnt  +downstreamnt
atggaggaggaggagggggcggtggccaaggagtggggcacgacccccgcggggcccgtc
tggaccgcggtgttcgactacgaggcggcgggcgacgaggagctgaccctgcggaggggc
gatcgcgtccaggtgctttcccaagactgtgcggtgtccggcgacgagggctggtggacc
gggcagctccccagcggccgcgtgggcgtcttccccagcaactacgtggcccccggcgcc
cccgctgcacccgcgggcctccagctgccccaggagatccccttccacgagctgcagcta
gaggagatcatcggtgtggggggctttggcaaggtctatcgggccctgtggcgtggcgag
gaggtggcagtcaaggccgcccggctggaccctgagaaggacccggcagtgacagcggag
caggtgtgccaggaagcccggctctttggagccctgcagcaccccaacataattgccctt
aggggcgcctgcctcaaccccccacacctctgcctagtgatggagtatgcccggggtggt
gcactgagcagggtgctggcaggtcgccgggtgccacctcacgtgctggtcaactgggct
gtgcaggtggcccggggcatgaactacctacacaatgatgcccctgtgcccatcatccac
cgggacctcaagtccatcaacatcctgatcctggaggccatcgagaaccacaacctcgca
gacacggtgctcaagatcacggacttcggcctcgcccgcgagtggcacaagaccaccaag
atgagcgctgcggggacctacgcctggatggcgccggaggttatccgtctctccctcttc
tccaaaagcagtgatgtctggagcttcggggtgctgctgtgggagctgctgacgggggag
gtcccctaccgtgagatcgacgccttggccgtggcgtatggcgtggctatgaataagctg
acgctgcccattccctccacgtgccccgagccctttgcccgcctcctggaggaatgctgg
gacccagacccccacgggcggccagatttcggtagcatcttgaagcggcttgaagtcatc
gaacagtcagccctgttccagatgccactggagtccttccactcgctgcaggaagactgg
aagctggagattcagcacatgtttgatgaccttcggaccaaggagaaggagcttcggagc
cgtgaggaggagctgctgcgggcggcacaggagcagcgcttccaggaggagcagctgcgg
cggcgggagcaggagctggcagaacgtgagatggacatcgtggaacgggagctgcacctg
ctcatgtgccagctgagccaggagaagccccgggtccgcaagcgcaagggcaacttcaag
cgcagccgcctgctcaagctgcgggaaggcggcagccacatcagcctgccctctggcttt
gagcataagatcacagtccaggcctctccaactctggataagcggaaaggatccgatggg
gccagcccccctgcaagccccagcatcatcccccggctgagggccattcgcctgactccc
gtggactgtggtggcagcagcagtggcagcagcagtggaggaagtgggacatggagccgc
ggtgggcccccaaagaaggaagaactggtcgggggcaagaagaagggacgaacgtggggg
cccagctccaccctgcagaaggagcgggtgggaggagaggagaggctgaaggggctgggg
gaaggaagcaaacagtggtcatcaagtgcccccaacctgggcaagtcccccaaacacaca
cccatcgcccctggctttgccagcctcaatgagatggaggagttcgcggaggcagaggat
ggaggcagcagcgtgcccccttccccctactcgaccccgtcctacctctcagtgccactg
cctgccgagccctccccgggggcgcgggcgccgtgggagccgacgccgtccgcgcccccc
gctcggtggggacacggcgcccggcggcgctgcgacctggcgctgctaggctgcgccacg
ctgctgggggctgtgggcctgggcgccgacgtggccgaggcgcgcgcggccgacggtgag
gagcagcggcgctggctcgacggcctcttctttccccgcgccggccgcttcccgcggggc
ctcagcccacccgcgcgtccccacggccgccgcgaagacgtgggccccggcctgggcctg
gcgccctcggccaccctcgtgtcgctgtcgtccgtgtccgactgcaactccacgcgttca
ctgctgcgctctgacagtgacgaggccgcaccggccgcgccctccccaccaccctccccg
cccgcgcccacacccacgccctcgcccagcaccaaccccctggtggacctggagctggag
agcttcaagaaggacccccgccagtcgctcacgcccacccacgtcacggctgcatgcgct
gtgagccgcgggcaccggcggacgccatcggacggggcgctggggcagcgggggccgccc
gagcccgcgggccatggccctggccctcgtgaccttctggacttcccccgcctgcccgac
ccccaggccctgttcccagcccgccgccggccccctgagttcccaggccgccccaccacc
ctgacctttgccccgagacctcggccggctgccagtcgcccccgcttggacccctggaaa
ctggtctccttcggccggacactcaccatctcgcctcccagcaggccagacactccggag
agccctgggccccccagcgtgcagcccacactgctggacatggacatggaggggcagaac
caagacagcacagtgcccctgtgcggggcccacggctcccactaa

KEGG   Homo sapiens (human): 4296
Entry
4296              CDS       T01001                                 
Symbol
MAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 11
  KO
K04419  mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04932  Non-alcoholic fatty liver disease
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4296 (MAP3K11)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4296 (MAP3K11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4296 (MAP3K11)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4296 (MAP3K11)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   4296 (MAP3K11)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 Pkinase_fungal Abi_alpha
Other DBs
NCBI-GeneID: 4296
NCBI-ProteinID: NP_002410
OMIM: 600050
HGNC: 6850
Ensembl: ENSG00000173327
UniProt: Q16584
Structure
LinkDB
Position
11:complement(65597757..65614221)
AA seq 847 aa
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP
NT seq 2544 nt   +upstreamnt  +downstreamnt
atggagcccttgaagagcctcttcctcaagagccctctagggtcatggaatggcagtggc
agcgggggtggtgggggcggtggaggaggccggcctgaggggtctccaaaggcagcgggt
tatgccaacccggtgtggacagccctgttcgactacgagcccagtgggcaggatgagctg
gccctgaggaagggtgaccgtgtggaggtgctgtcccgggacgcagccatctcaggagac
gagggctggtgggcgggccaggtgggtggccaggtgggcatcttcccgtccaactatgtg
tctcggggtggcggcccgcccccctgcgaggtggccagcttccaggagctgcggctggag
gaggtgatcggcattggaggctttggcaaggtgtacaggggcagctggcgaggtgagctg
gtggctgtgaaggcagctcgccaggaccccgatgaggacatcagtgtgacagccgagagc
gttcgccaggaggcccggctcttcgccatgctggcacaccccaacatcattgccctcaag
gctgtgtgcctggaggagcccaacctgtgcctggtgatggagtatgcagccggtgggccc
ctcagccgagctctggccgggcggcgcgtgcctccccatgtgctggtcaactgggctgtg
cagattgcccgtgggatgcactacctgcactgcgaggccctggtgcccgtcatccaccgt
gatctcaagtccaacaacattttgctgctgcagcccattgagagtgacgacatggagcac
aagaccctgaagatcaccgactttggcctggcccgagagtggcacaaaaccacacaaatg
agtgccgcgggcacctacgcctggatggctcctgaggttatcaaggcctccaccttctct
aagggcagtgacgtctggagttttggggtgctgctgtgggaactgctgaccggggaggtg
ccataccgtggcattgactgccttgctgtggcctatggcgtagctgttaacaagctcaca
ctgcccatcccatccacctgccccgagcccttcgcacagcttatggccgactgctgggcg
caggacccccaccgcaggcccgacttcgcctccatcctgcagcagttggaggcgctggag
gcacaggtcctacgggaaatgccgcgggactccttccattccatgcaggaaggctggaag
cgcgagatccagggtctcttcgacgagctgcgagccaaggaaaaggaactactgagccgc
gaggaggagctgacgcgagcggcgcgcgagcagcggtcacaggcggagcagctgcggcgg
cgcgagcacctgctggcccagtgggagctagaggtgttcgagcgcgagctgacgctgctg
ctgcagcaggtggaccgcgagcgaccgcacgtgcgccgccgccgcgggacattcaagcgc
agcaagctccgggcgcgcgacggcggcgagcgtatcagcatgccactcgacttcaagcac
cgcatcaccgtgcaggcctcacccggccttgaccggaggagaaacgtcttcgaggtcggg
cctggggattcgcccacctttccccggttccgagccatccagttggagcctgcagagcca
ggccaggcatggggccgccagtccccccgacgtctggaggactcaagcaatggagagcgg
cgagcatgctgggcttggggtcccagttcccccaagcctggggaagcccagaatgggagg
agaaggtcccgcatggacgaagccacatggtacctggattcagatgactcatccccctta
ggatctccttccacacccccagcactcaatggtaaccccccgcggcctagcctggagccc
gaggagcccaagaggcctgtccccgcagagcgcggtagcagctctgggacgcccaagctg
atccagcgggcgctgctgcgcggcaccgccctgctcgcctcgctgggccttggccgcgac
ctgcagccgccgggaggcccaggacgcgagcgcggggagtccccgacaacaccccccacg
ccaacgcccgcgccctgcccgaccgagccgcccccttccccgctcatctgcttctcgctc
aagacgcccgactccccgcccactcctgcacccctgttgctggacctgggtatccctgtg
ggccagcggtcagccaagagcccccgacgtgaggaggagccccgcggaggcactgtctca
cccccaccggggacatcacgctctgctcctggcaccccaggcaccccacgttcaccaccc
ctgggcctcatcagccgacctcggccctcgccccttcgcagccgcattgatccctggagc
tttgtgtcagctgggccacggccttctcccctgccatcaccacagcctgcaccccgccga
gcaccctggaccttgttcccggactcagaccccttctgggactccccacctgccaacccc
ttccaggggggcccccaggactgcagggcacagaccaaagacatgggtgcccaggccccg
tgggtgccggaagcggggccttga

KEGG   Homo sapiens (human): 84451
Entry
84451             CDS       T01001                                 
Symbol
MAP3K21, MLK4, dJ862P8.3
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 21
  KO
K17534  mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    84451 (MAP3K21)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    84451 (MAP3K21)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     84451 (MAP3K21)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   84451 (MAP3K21)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 ABC1 Pkinase_fungal RNase_Y_N
Other DBs
NCBI-GeneID: 84451
NCBI-ProteinID: NP_115811
OMIM: 614793
HGNC: 29798
Ensembl: ENSG00000143674
UniProt: Q5TCX8
Structure
LinkDB
Position
1:233327724..233385148
AA seq 1036 aa
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS
NT seq 3111 nt   +upstreamnt  +downstreamnt
atggctttgcggggcgccgcgggagcgaccgacaccccggtgtcctcggccgggggagcc
cccggcggctcagcgtcctcgtcgtccacctcctcgggcggctcggcctcggcgggcgcg
gggctgtgggccgcgctctatgactacgaggctcgcggcgaggacgagctgagcctgcgg
cgcggccagctggtggaggtgctgtcgcaggacgccgccgtgtcgggcgacgagggctgg
tgggcaggccaggtgcagcggcgcctcggcatcttccccgccaactacgtggctccctgc
cgcccggccgccagccccgcgccgccgccctcgcggcccagctccccggtacacgtcgcc
ttcgagcggctggagctgaaggagctcatcggcgctgggggcttcgggcaggtgtaccgc
gccacctggcagggccaggaggtggccgtgaaggcggcgcgccaggacccggagcaggac
gcggcggcggctgccgagagcgtgcggcgcgaggctcggctcttcgccatgctgcggcac
cccaacatcatcgagctgcgcggcgtgtgcctgcagcagccgcacctctgcctggtgctg
gagttcgcccgcggcggagcgctcaaccgagcgctggccgctgccaacgccgccccggac
ccgcgcgcgcccggcccccgccgcgcgcgccgcatccctccgcacgtgctggtcaactgg
gccgtgcagatagcgcggggcatgctctacctgcatgaggaggccttcgtgcccatcctg
caccgggacctcaagtccagcaacattttgctacttgagaagatagaacatgatgacatc
tgcaataaaactttgaagattacagattttgggttggcgagggaatggcacaggaccacc
aaaatgagcacagcaggcacctatgcctggatggcccccgaagtgatcaagtcttccttg
ttttctaagggaagcgacatctggagctatggagtgctgctgtgggaactgctcaccgga
gaagtcccctatcggggcattgatggcctcgccgtggcttatggggtagcagtcaataaa
ctcactttgcccattccatccacctgccctgagccgtttgccaagctcatgaaagaatgc
tggcaacaagaccctcatattcgtccatcgtttgccttaattctcgaacagttgactgct
attgaaggggcagtgatgactgagatgcctcaagaatcttttcattccatgcaagatgac
tggaaactagaaattcaacaaatgtttgatgagttgagaacaaaggaaaaggagctgcga
tcccgggaagaggagctgactcgggcggctctgcagcagaagtctcaggaggagctgcta
aagcggcgtgagcagcagctggcagagcgcgagatcgacgtgctggagcgggaacttaac
attctgatattccagctaaaccaggagaagcccaaggtaaagaagaggaagggcaagttt
aagagaagtcgtttaaagctcaaagatggacatcgaatcagtttaccttcagatttccag
cacaagataaccgtgcaggcctctcccaacttggacaaacggcggagcctgaacagcagc
agttccagtcccccgagcagccccacaatgatgccccgactccgagccatacagttgact
tcagatgaaagcaataaaacttggggaaggaacacagtctttcgacaagaagaatttgag
gatgtaaaaaggaattttaagaaaaaaggttgtacctggggaccaaattccattcaaatg
aaagatagaacagattgcaaagaaaggataagacctctctccgatggcaacagtccttgg
tcaactatcttaataaaaaatcagaaaaccatgcccttggcttcattgtttgtggaccag
ccagggtcctgtgaagagccaaaactttcccctgatggattagaacacagaaaaccaaaa
caaataaaattgcctagtcaggcctacattgatctacctcttgggaaagatgctcagaga
gagaatcctgcagaagctgaaagctgggaggaggcagcctctgcgaatgctgccacagtc
tccattgagatgactcctacgaatagtctgagtagatccccccagagaaagaaaacggag
tcagctctgtatgggtgcaccgtccttctggcatcggtggctctgggactggacctcaga
gagcttcataaagcacaggctgctgaagaaccgttgcccaaggaagagaagaagaaacga
gagggaatcttccagcgggcttccaagtcccgcagaagcgccagtcctcccacaagcctg
ccatccacctgtggggaggccagcagcccaccctccctgccactgtcaagtgccctgggc
atcctctccacaccttctttctccacaaagtgcctgctgcagatggacagtgaagatcca
ctggtggacagtgcacctgtcacttgtgactctgagatgctcactccggatttttgtccc
actgccccaggaagtggtcgtgagccagccctcatgccaagacttgacactgattgtagt
gtatcaagaaacttgccgtcttccttcctacagcagacatgtgggaatgtaccttactgt
gcttcttcaaaacatagaccgtcacatcacagacggaccatgtctgatggaaatccgacc
ccaactggtgcaactattatctcagccactggagcctctgcactgccactctgcccctca
cctgctcctcacagtcatctgccaagggaggtctcacccaagaagcacagcactgtccac
atcgtgcctcagcgtcgccctgcctccctgagaagccgctcagatctgcctcaggcttac
ccacagacagcagtgtctcagctggcacagactgcctgtgtagtgggtcgcccaggacca
catcccacccaattcctcgctgccaaggagagaactaaatcccatgtgccttcattactg
gatgctgacgtggaaggtcagagcagggactacactgtgccactgtgcagaatgaggagc
aaaaccagccggccatctatatatgaactggagaaagaattcctgtcttaa

KEGG   Homo sapiens (human): 7786
Entry
7786              CDS       T01001                                 
Symbol
MAP3K12, DLK, HP09298, MEKK12, MUK, ZPK, ZPKP1
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 12
  KO
K04423  mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7786 (MAP3K12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7786 (MAP3K12)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     7786 (MAP3K12)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   7786 (MAP3K12)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Pkinase_fungal ABC1
Other DBs
NCBI-GeneID: 7786
NCBI-ProteinID: NP_006292
OMIM: 600447
HGNC: 6851
Ensembl: ENSG00000139625
UniProt: Q12852
Structure
LinkDB
Position
12:complement(53479669..53501539)
AA seq 859 aa
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
NT seq 2580 nt   +upstreamnt  +downstreamnt
atggcttgcctccatgagacccgaacaccctctccttcctttgggggctttgtgtctacc
ctaagtgaggcatccatgcgcaagctggacccagacacttctgactgcactcccgagaag
gacctgacgcctacccatgtcctgcagctacatgagcaggatgcagggggcccaggggga
gcagctgggtcacctgagagtcgggcatccagagttcgagctgacgaggtgcgactgcag
tgccagagtggcagtggcttccttgagggcctctttggctgcctgcgccctgtctggacc
atgattggcaaagcctactccactgagcacaagcagcagcaggaagacctttgggaggtc
ccctttgaggaaatcctggacctgcagtgggtgggctcaggggcccagggtgctgtcttc
ctggggcgcttccacggggaggaggtggctgtgaagaaggtgcgagacctcaaagaaacc
gacatcaagcacttgcgaaagctgaagcaccccaacatcatcactttcaagggtgtgtgc
acccaggctccctgctactgcatcctcatggagttctgcgcccagggccagctgtatgag
gtactgcgggctggccgccctgtcaccccctccttactggttgactggtccatgggcatc
gctggtggcatgaactacctgcacctgcacaagattatccacagggatctcaagtcaccc
aacatgctaatcacctacgacgatgtggtgaagatctcagattttggcacttccaaggag
ctgagtgacaagagcaccaagatgtcctttgcagggacagtagcctggatggcccctgag
gtgatccgcaatgaacctgtgtctgagaaggtcgacatctggtcctttggcgtggtgcta
tgggaactgctgactggtgagatcccctacaaagacgtagattcctcagccattatctgg
ggtgtgggaagcaacagtctccatctgcccgtgccctccagttgcccagatggtttcaag
atcctgcttcgccagtgctggaatagcaaaccacgaaatcgcccatcattccgacagatc
ctgctgcatctggacattgcctcagctgatgtactctccacaccccaggagacttacttt
aagtcccaggcagagtggcgggaagaagtaaaactgcactttgaaaagattaagtcagaa
gggacctgtctgcaccgcctagaagaggaactggtgatgaggaggagggaggagctcaga
cacgccctggacatcagggagcactatgaaaggaagctggagagagccaacaacctgtat
atggaacttaatgccctcatgttgcagctggaactcaaggagagggagctgctcaggcga
gagcaagctttagagcggaggtgcccaggcctgctgaagccacacccttcccggggcctc
ctgcatggaaacacaatggagaagcttatcaagaagaggaatgtgccacagaagctgtca
ccccatagcaaaaggccagatatcctcaagacggagtctttgctccctaaactagatgca
gccctgagtggggtggggcttcctgggtgtcctaagggccccccctcaccaggacggagt
cgccgtggcaagacccgtcaccgcaaggccagcgccaaggggagctgtggggacctgcct
gggcttcgtacagctgtgccaccccatgaacctggaggaccaggaagcccagggggccta
ggagggggaccctcagcctgggaggcctgccctcccgccctccgtgggcttcatcatgac
ctcctgctccgcaaaatgtcttcatcgtccccagacctgctgtcagcagcactagggtcc
cggggccggggggccacaggcggagctggggatcctggctcaccacctccggcccggggt
gacaccccaccaagtgagggctcagcccctggctccaccagcccagattcacctggggga
gccaaaggggaaccacctcctccagtagggcctggtgaaggtgtggggcttctgggaact
ggaagggaagggacctcaggccggggaggaagccgggctgggtcccagcacttgacccca
gctgcactgctgtacagggctgccgtcacccgaagtcagaaacgtggcatctcatcggaa
gaggaggaaggagaggtagacagtgaagtagagctgacatcaagccagaggtggcctcag
agcctgaacatgcgccagtcactatctaccttcagctcagagaatccatcagatggggag
gaaggcacagctagtgaaccttcccccagtggcacacctgaagttggcagcaccaacact
gatgagcggccagatgagcggtctgatgacatgtgctcccagggctcagaaatcccactg
gacccacctccttcagaggtcatccctggccctgaacccagctccctgcccattccacac
caggaacttctcagagagcggggccctcccaattctgaggactcagactgtgacagcact
gaattggacaactccaacagcgttgatgccttgcggcccccagcttccctccctccatga

KEGG   Homo sapiens (human): 9175
Entry
9175              CDS       T01001                                 
Symbol
MAP3K13, LZK, MEKK13, MLK
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 13
  KO
K04422  mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    9175 (MAP3K13)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9175 (MAP3K13)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     9175 (MAP3K13)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   9175 (MAP3K13)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase ABC1 Pkinase_fungal
Other DBs
NCBI-GeneID: 9175
NCBI-ProteinID: NP_001229243
OMIM: 604915
HGNC: 6852
Ensembl: ENSG00000073803
UniProt: O43283
LinkDB
Position
3:185282961..185489094
AA seq 966 aa
MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
YSSATW
NT seq 2901 nt   +upstreamnt  +downstreamnt
atggccaactttcaggagcacctgagctgctcctcttctccacacttacccttcagtgaa
agcaaaaccttcaatggactacaagatgagctcacagctatggggaaccacccttctccc
aagctgctcgaggaccagcaggaaaaggggatggtacgaacagagctaatcgagagcgtg
cacagccccgtcaccacaacagtgttgacgagcgtaagtgaggattccagggaccagttt
gagaacagcgttcttcagctaagggaacacgatgaatcagagacggcggtgtctcagggg
aacagcaacacggtggacggagagagcacaagcggaactgaagacataaagattcagttc
agcaggtcaggcagtggcagtggtgggtttcttgaaggactatttggatgcttaaggcct
gtatggaatatcattgggaaggcatattccactgattacaaattgcagcagcaagatact
tgggaagtgccatttgaggagatctcagagctgcagtggctgggtagtggagcccaagga
gcggtcttcttgggcaagttccgggcggaagaggtggccatcaagaaagtgagagaacag
aatgagacggatatcaagcatttgaggaagttgaagcaccctaacatcatcgcattcaag
ggtgtttgtactcaggccccatgttattgtattatcatggaatactgtgcccatggacaa
ctctacgaggtcttacgagctggcaggaagatcacacctcgattgctagtagactggtcc
acaggaattgcaagtggaatgaattatttgcacctccataaaattattcatcgtgatctc
aaatcacctaatgttttagtgacccacacagatgcggtaaaaatttcagattttggtaca
tctaaggaactcagtgacaaaagtaccaagatgtcatttgctggcacggtcgcatggatg
gcgccagaggtgatacggaatgaacctgtctctgaaaaagttgatatatggtcttttgga
gtggtgctttgggagctgctgacaggagagatcccttacaaagatgtagattcttcagcc
attatctggggtgttggaagcaacagcctccaccttccagttccttccacttgccctgat
ggattcaaaatccttatgaaacagacgtggcagagtaaacctcgaaaccgaccttctttt
cggcagacactcatgcatttagacattgcctctgcagatgtacttgccaccccacaagaa
acttacttcaagtctcaggctgaatggagagaagaagtgaaaaaacattttgagaagatc
aaaagtgaaggaacttgtatacaccggttagatgaagaactgattcgaaggcgcagagaa
gagctcaggcatgcgctggatattcgtgaacactatgagcggaagcttgagcgggcgaat
aatttatacatggaattgagtgccatcatgctgcagctagaaatgcgggagaaggagctc
attaagcgtgagcaagcagtggaaaagaagtatcctgggacctacaaacgacaccctgtt
cgtcctatcatccatcccaatgccatggagaaactcatgaaaaggaaaggagtgcctcac
aaatctgggatgcagaccaaacggccagacttgttgagatcagaagggatccccaccaca
gaagtggctcccactgcatcccctttgtccggaagtcccaaaatgtccacttctagcagc
aagagccgatatcgaagcaaaccacgccaccgccgagggaatagcagaggcagccatagt
gactttgccgcaatcttgaaaaaccagccagcccaggaaaattcaccccatcccacttac
ctgcaccaagctcaatcccaatacccttctcttcatcaccataattctctgcagcagcaa
taccagcagccccctcctgccatgtcccagagtcaccatcccagactcaatatgcacgga
caggacatagcaacctgcgccaacaacctgaggtatttcggcccagcagcagccctgcgg
agcccactcagcaaccatgctcagagacagctgcccggctcgagccctgacctcatctcc
acagccatggctgcagactgctggagaagttctgagcctgacaagggccaagctggtccc
tggggctgttgccaggctgacgcttatgacccctgccttcagtgcaggccagaacagtat
gggtccttagacataccctctgctgagccagtggggaggagccctgacctttccaagtca
ccagcacataatcctctcttggaaaacgcccagagttctgagaaaacggaagaaaatgaa
ttcagcggctgtaggtctgagtcatccctcggcacctctcatctcggcacccctccagcg
ctacctcgaaaaacaaggcctctgcagaagagtggagatgactcctcagaagaggaagaa
ggggaagtagatagtgaagttgaatttccacgaagacagaggccccatcgctgtatcagc
agctgccagtcatattcaacctttagctctgagaatttctctgtgtctgatggagaagag
ggaaataccagtgaccactcaaacagtcctgatgagttagctgataaacttgaagaccgc
ttggcagagaagctagacgacctgctgtcccagacgccagagattcccattgacatatcc
tcacactcggatgggctctctgacaaggagtgtgccgtgcgccgtgtgaagactcagatg
tctctgggcaagctgtgtgtggaggaacgtggctatgagaaccccatgcagtttgaagaa
tcggactgtgactcttcagatggggagtgttctgatgccacagttaggaccaataaacac
tacagctctgctacctggtaa

KEGG   Homo sapiens (human): 51776
Entry
51776             CDS       T01001                                 
Symbol
MAP3K20, AZK, CNM6, MLK7, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, SFMMP, ZAK, mlklak, pk
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 20
  KO
K04424  sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Disease
H00471  Split-hand/foot malformation
H00700  Centronuclear myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    51776 (MAP3K20)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    51776 (MAP3K20)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     51776 (MAP3K20)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   51776 (MAP3K20)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SAM_1 SAM_2 SAM_PNT ABC1 SAM_Ste50p SAM_4
Other DBs
NCBI-GeneID: 51776
NCBI-ProteinID: NP_057737
OMIM: 609479
HGNC: 17797
Ensembl: ENSG00000091436
UniProt: Q9NYL2
Structure
LinkDB
Position
2:173075517..173268015
AA seq 800 aa
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
SPAKTNKERARGDHRGWRNF
NT seq 2403 nt   +upstreamnt  +downstreamnt
atgtcgtctctcggtgcctcctttgtgcaaattaaatttgatgacttgcagttttttgaa
aactgcggtggaggaagttttgggagtgtttatcgagccaaatggatatcacaggacaag
gaggtggctgtaaagaagctcctcaaaatagagaaagaggcagaaatactcagtgtcctc
agtcacagaaacatcatccagttttatggagtaattcttgaacctcccaactatggcatt
gtcacagaatatgcttctctgggatcactctatgattacattaacagtaacagaagtgag
gagatggatatggatcacattatgacctgggccactgatgtagccaaaggaatgcattat
ttacatatggaggctcctgtcaaggtgattcacagagacctcaagtcaagaaacgttgtt
atagctgctgatggagtattgaagatctgtgactttggtgcctctcggttccataaccat
acaacacacatgtccttggttggaactttcccatggatggctccagaagttatccagagt
ctccctgtgtcagaaacttgtgacacatattcctatggtgtggttctctgggagatgcta
acaagggaggtcccctttaaaggtttggaaggattacaagtagcttggcttgtagtggaa
aaaaacgagagattaaccattccaagcagttgccccagaagttttgctgaactgttacat
cagtgttgggaagctgatgccaagaaacggccatcattcaagcaaatcatttcaatcctg
gagtccatgtcaaatgacacgagccttcctgacaagtgtaactcattcctacacaacaag
gcggagtggaggtgcgaaattgaggcaactcttgagaggctaaagaaactagagcgtgat
ctcagctttaaggagcaggagcttaaagaacgagaaagacgtttaaagatgtgggagcaa
aagctgacagagcagtccaacaccccgctgctgccttcctttgagattggtgcatggacg
gaagacgatgtgtattgttgggttcagcagctcgtcagaaaaggtgactcttcagcagag
atgagtgtatatgcaagcttgtttaaagaaaacaacattacagggaagcggctgctgctg
ctggaggaagaagacctgaaagacatgggcattgtctccaaggggcatatcattcacttc
aagtcagccattgagaaattaacccatgattacataaatttgtttcacttcccaccacta
attaaggactcaggaggtgaacctgaagaaaatgaggaaaaaatagtgaacctggaactg
gtttttggttttcacttgaaaccaggaactggcccacaggattgtaagtggaaaatgtat
atggagatggatggggatgaaattgcaataacctacataaaagatgtgacattcaacact
aacctacctgatgcggagattttaaagatgacaaagccaccatttgtaatggagaagtgg
attgtaggaatagcaaaaagtcagactgtggagtgcactgtcacatatgagagtgatgtt
agaactccaaaaagcactaaacatgtccattcgattcagtggagtagaacaaaacctcag
gatgaagtgaaagcagtccaacttgccattcagacattattcaccaattcagatggcaac
cctggaagcaggtccgactcaagtgctgattgccagtggttagatactctgaggatgcgg
cagattgcatccaacacttctttacagcgttcccagagcaatcctattctggggtcaccg
ttcttctcacactttgatggccaggattcctacgctgctgctgtgagacggccccaggtg
cccattaagtatcaacagattacacctgtgaaccagtccagaagctcgtctcctactcag
tatggactgaccaaaaacttctcttccctacatctcaactctagggacagtggcttttcc
agtggcaatactgacacctcttcagagaggggtcgatactcagacagaagcaggaacaaa
tatggacgtggtagtatatcactcaattcttctcctagaggaagatacagtggaaagagt
cagcattccactccttcaagaggaagataccctggaaagttctacagggtttctcagtca
gcactcaatcctcaccagtcgcctgacttcaagagaagccccagggacctccaccaaccc
aacaccataccagggatgcctttgcaccctgagactgactcaagagccagtgaagaggac
agcaaagtcagcgaagggggctggacaaaagtggaataccggaaaaagccccacaggcca
tctcccgccaaaaccaataaagagagagccagaggggaccaccgtggatggagaaacttt
tga

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