KEGG   NETWORK: N01307
Entry
N01307                      Network                                

Name
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Definition
S -| ACE2 -| AngII -> AGTR1 -> NOX2 -> ROS -> NFKB -> (TNF,IL6,IL1B,IL12,MMP3,MMP1,CCL2,CXCL8)
  Expanded
K24152 -| 59272 -| C02135 -> 185 -> 1536 -> (C00704+C00027) -> (4790+5970) -> (7124,3569,3553,3592,3593,4314,4312,6347,3576)
Class
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
59272  ACE2; angiotensin I converting enzyme 2
185  AGTR1; angiotensin II receptor type 1
1536  CYBB; cytochrome b-245 beta chain
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
3553  IL1B; interleukin 1 beta
3592  IL12A; interleukin 12A
3593  IL12B; interleukin 12B
4314  MMP3; matrix metallopeptidase 3
4312  MMP1; matrix metallopeptidase 1
6347  CCL2; C-C motif chemokine ligand 2
3576  CXCL8; C-X-C motif chemokine ligand 8
Perturbant
K24152 (S)  S; SARS coronavirus spike glycoprotein
Metabolite
C02135  Angiotensin II
C00704  Superoxide
C00027  Hydrogen peroxide
Reference
  Authors
Gubernatorova EO, Gorshkova EA, Polinova AI, Drutskaya MS
  Title
IL-6: Relevance for immunopathology of SARS-CoV-2.
  Journal
Cytokine Growth Factor Rev 53:13-24 (2020)
DOI:10.1016/j.cytogfr.2020.05.009
Reference
  Authors
Banu N, Panikar SS, Leal LR, Leal AR
  Title
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications.
  Journal
Life Sci 256:117905 (2020)
DOI:10.1016/j.lfs.2020.117905
Reference
  Authors
Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS
  Title
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.
  Journal
Intensive Care Med 46:586-590 (2020)
DOI:10.1007/s00134-020-05985-9
Reference
  Authors
Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A, Laurence J
  Title
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.
  Journal
Transl Res 220:1-13 (2020)
DOI:10.1016/j.trsl.2020.04.007
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