Homo sapiens (human): 4720
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Entry
4720 CDS
T01001
Symbol
NDUFS2, CI-49, LHONAR2, MC1DN6
Name
(RefSeq) NADH:ubiquinone oxidoreductase core subunit S2
KO
K03935
NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:
7.1.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00190
Oxidative phosphorylation
hsa01100
Metabolic pathways
hsa04714
Thermogenesis
hsa04723
Retrograde endocannabinoid signaling
hsa04932
Non-alcoholic fatty liver disease
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05415
Diabetic cardiomyopathy
Module
hsa_M00143
NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
Network
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06529
Thermogenesis
Element
N00995
Electron transfer in Complex I
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01042
Mutation-caused aberrant SNCA to electron transfer in Complex I
N01043
Mutation-inactivated PINK1 to electron transfer in Complex I
N01044
MPP+ to electron transfer in Complex I
N01045
Rotenone to electron transfer in Complex I
N01136
Mutation-caused aberrant TDP43 to electron transfer in Complex I
N01691
mitochondrial complex - UCP1 in Thermogenesis
Disease
H00473
Mitochondrial complex I deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09102 Energy metabolism
00190 Oxidative phosphorylation
4720 (NDUFS2)
09150 Organismal Systems
09156 Nervous system
04723 Retrograde endocannabinoid signaling
4720 (NDUFS2)
09159 Environmental adaptation
04714 Thermogenesis
4720 (NDUFS2)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
4720 (NDUFS2)
09164 Neurodegenerative disease
05010 Alzheimer disease
4720 (NDUFS2)
05012 Parkinson disease
4720 (NDUFS2)
05014 Amyotrophic lateral sclerosis
4720 (NDUFS2)
05016 Huntington disease
4720 (NDUFS2)
05020 Prion disease
4720 (NDUFS2)
05022 Pathways of neurodegeneration - multiple diseases
4720 (NDUFS2)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
4720 (NDUFS2)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
4720 (NDUFS2)
Enzymes [BR:
hsa01000
]
7. Translocases
7.1 Catalysing the translocation of protons
7.1.1 Linked to oxidoreductase reactions
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
4720 (NDUFS2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Complex1_49kDa
NiFeSe_Hases
Motif
Other DBs
NCBI-GeneID:
4720
NCBI-ProteinID:
NP_004541
OMIM:
602985
HGNC:
7708
Ensembl:
ENSG00000158864
UniProt:
O75306
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:161197417..161214395
Genome browser
AA seq
463 aa
AA seq
DB search
MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAH
WKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGT
EKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRL
LNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGL
MDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQW
DLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDD
AKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPY
RCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
NT seq
1392 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagggctttgtgcggcttccggggcgtcgcggcccaggtgctgcggcct
ggggctggagtccgattgccgattcagcccagcagaggtgttcggcagtggcagccagat
gtggaatgggcacagcagtttgggggagctgttatgtacccaagcaaagaaacagcccac
tggaagcctccaccttggaatgatgtggaccctccaaaggacacaattgtgaagaacatt
accctgaactttgggccccaacacccagcagcgcatggtgtcctgcgactagtgatggaa
ttgagtggggagatggtgcggaagtgtgatcctcacatcgggctcctgcaccgaggcact
gagaagctcattgaatacaagacctatcttcaggcccttccatactttgaccggctagac
tatgtgtccatgatgtgtaacgaacaggcctattctctagctgtggagaagttgctaaac
atccggcctcctcctcgggcacagtggatccgagtgctgtttggagaaatcacacgtttg
ttgaaccacatcatggctgtgaccacacatgccctggaccttggggccatgacccctttc
ttctggctgtttgaagaaagggagaagatgtttgagttctacgagcgagtgtctggagcc
cgaatgcatgctgcttatatccggccaggaggagtgcaccaggacctaccccttgggctt
atggatgacatttatcagttttctaagaacttctctcttcggcttgatgagttggaggag
ttgctgaccaacaataggatctggcgaaatcggacaattgacattggggttgtaacagca
gaagaagcacttaactatggttttagtggagtgatgcttcggggctcaggcatccagtgg
gacctgcggaagacccagccctatgatgtttacgaccaggttgagtttgatgttcctgtt
ggttctcgaggggactgctatgataggtacctgtgccgggtggaggagatgcgccagtcc
ctgagaattatcgcacagtgtctaaacaagatgcctcctggggagatcaaggttgatgat
gccaaagtgtctccacctaagcgagcagagatgaagacttccatggagtcactgattcat
cactttaagttgtatactgagggctaccaagttcctccaggagccacatatactgccatt
gaggctcccaagggagagtttggggtgtacctggtgtctgatggcagcagccgcccttat
cgatgcaagatcaaggctcctggttttgcccatctggctggtttggacaagatgtctaag
ggacacatgttggcagatgtcgttgccatcataggtacccaagatattgtatttggagaa
gtagatcggtga
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