Homo sapiens (human): 4722
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Entry
4722 CDS
T01001
Symbol
NDUFS3, CI-30, MC1DN8
Name
(RefSeq) NADH:ubiquinone oxidoreductase core subunit S3
KO
K03936
NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:
7.1.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00190
Oxidative phosphorylation
hsa01100
Metabolic pathways
hsa04714
Thermogenesis
hsa04723
Retrograde endocannabinoid signaling
hsa04932
Non-alcoholic fatty liver disease
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05415
Diabetic cardiomyopathy
Module
hsa_M00143
NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
Network
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06529
Thermogenesis
Element
N00995
Electron transfer in Complex I
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01042
Mutation-caused aberrant SNCA to electron transfer in Complex I
N01043
Mutation-inactivated PINK1 to electron transfer in Complex I
N01044
MPP+ to electron transfer in Complex I
N01045
Rotenone to electron transfer in Complex I
N01136
Mutation-caused aberrant TDP43 to electron transfer in Complex I
N01691
mitochondrial complex - UCP1 in Thermogenesis
Disease
H00473
Mitochondrial complex I deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09102 Energy metabolism
00190 Oxidative phosphorylation
4722 (NDUFS3)
09150 Organismal Systems
09156 Nervous system
04723 Retrograde endocannabinoid signaling
4722 (NDUFS3)
09159 Environmental adaptation
04714 Thermogenesis
4722 (NDUFS3)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
4722 (NDUFS3)
09164 Neurodegenerative disease
05010 Alzheimer disease
4722 (NDUFS3)
05012 Parkinson disease
4722 (NDUFS3)
05014 Amyotrophic lateral sclerosis
4722 (NDUFS3)
05016 Huntington disease
4722 (NDUFS3)
05020 Prion disease
4722 (NDUFS3)
05022 Pathways of neurodegeneration - multiple diseases
4722 (NDUFS3)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
4722 (NDUFS3)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
4722 (NDUFS3)
Enzymes [BR:
hsa01000
]
7. Translocases
7.1 Catalysing the translocation of protons
7.1.1 Linked to oxidoreductase reactions
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
4722 (NDUFS3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Complex1_30kDa
Motif
Other DBs
NCBI-GeneID:
4722
NCBI-ProteinID:
NP_004542
OMIM:
603846
HGNC:
7710
Ensembl:
ENSG00000213619
UniProt:
O75489
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:47579074..47584562
Genome browser
AA seq
264 aa
AA seq
DB search
MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSA
FGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVP
TRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFAN
HPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWE
AFPVYRQPPESLKLEAGDKKPDAK
NT seq
795 nt
NT seq
+upstream
nt +downstream
nt
atggcggcggcggcggtagccaggctgtggtggcgcgggatcttgggggcctcggcgctg
accagggggactgggcgaccctccgttctgttgctgccggtgaggcgggagagcgccggg
gccgacacgcgccccactgtcagaccacggaatgatgtggcccacaagcagctctcagct
tttggagagtatgtggctgaaatcttgcccaagtatgtccaacaagttcaggtgtcctgc
ttcaatgagttagaggtctgtatccatcctgatggcgtcatcccagtgctgactttcctc
agggatcacaccaatgcacagttcaaatctctggttgacttgacagcagtggacgtccca
actcggcaaaaccgttttgagattgtctacaacctgttgtctctgcgcttcaactcacgg
atccgtgtgaagacctacacagatgagctgacgcccattgagtctgctgtctctgtgttc
aaggcagccaactggtatgaaagggagatctgggacatgtttggagtcttctttgctaac
caccctgatctaagaaggatcctgacagattatggcttcgagggacatcctttccggaaa
gactttcctctatctggctatgttgagttacgttatgatgatgaagtgaagcgggtggtg
gcagagccggtggagttggcccaagagttccgcaaatttgacctgaacagcccctgggag
gctttcccagtctatcgccaacccccggagagtctcaagcttgaagccggagacaagaag
cctgatgccaagtag
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