Homo sapiens (human): 4846 Help Entry 4846              CDS       T01001                                  Symbol NOS3, ECNOS, eNOS Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism hsa  Homo sapiens (human) Pathway hsa00220   Arginine biosynthesis hsa00330   Arginine and proline metabolism hsa01100   Metabolic pathways hsa04020   Calcium signaling pathway hsa04022   cGMP-PKG signaling pathway hsa04066   HIF-1 signaling pathway hsa04071   Sphingolipid signaling pathway hsa04151   PI3K-Akt signaling pathway hsa04370   VEGF signaling pathway hsa04371   Apelin signaling pathway hsa04611   Platelet activation hsa04915   Estrogen signaling pathway hsa04921   Oxytocin signaling pathway hsa04926   Relaxin signaling pathway hsa04931   Insulin resistance hsa04933   AGE-RAGE signaling pathway in diabetic complications hsa05415   Diabetic cardiomyopathy hsa05417   Lipid and atherosclerosis hsa05418   Fluid shear stress and atherosclerosis Disease H01529   Avascular necrosis of femoral head H01633   High blood pressure Drug target Pimagedine hydrochloride:  D05479 Tilarginine acetate:  D09018 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     4846 (NOS3)    00330 Arginine and proline metabolism     4846 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     4846 (NOS3)    04071 Sphingolipid signaling pathway     4846 (NOS3)    04022 cGMP-PKG signaling pathway     4846 (NOS3)    04151 PI3K-Akt signaling pathway     4846 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     4846 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     4846 (NOS3)    04921 Oxytocin signaling pathway     4846 (NOS3)    04926 Relaxin signaling pathway     4846 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     4846 (NOS3)    05418 Fluid shear stress and atherosclerosis     4846 (NOS3)    05415 Diabetic cardiomyopathy     4846 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     4846 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     4846 (NOS3) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      4846 (NOS3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  4846 NCBI-ProteinID:  NP_000594 OMIM:  163729 HGNC:  7876 Ensembl:  ENSG00000164867 UniProt:  P29474 Structure PDBPDBj LinkDB All DBs Position 7:150991017..151014588 Genome browser AA seq 1203 aa AA seqDB search MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPP ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT NSP NT seq 3612 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagcgtggcccaggagcctgggccaccctgcggcctggggctgggg ctgggccttgggctgtgcggcaagcagggcccagccaccccggcccctgagcccagccgg gccccagcatccctactcccaccagcgccagaacacagccccccgagctccccgctaacc cagcccccagaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcacc tatgacaccctcagcgcccaggcgcagcaggatgggccctgcaccccaagacgctgcctg ggctccctggtatttccacggaaactacagggccggccctcccccggccccccggcccct gagcagctgctgagtcaggcccgggacttcatcaaccagtactacagctccattaagagg agcggctcccaggcccacgaacagcggcttcaagaggtggaagccgaggtggcagccaca ggcacctaccagcttagggagagcgagctggtgttcggggctaagcaggcctggcgcaac gctccccgctgcgtgggccggatccagtgggggaagctgcaggtgttcgatgcccgggac tgcaggtctgcacaggaaatgttcacctacatctgcaaccacatcaagtatgccaccaac cggggcaaccttcgctcggccatcacagtgttcccgcagcgctgccctggccgaggagac ttccgaatctggaacagccagctggtgcgctacgcgggctaccggcagcaggatggctct gtgcggggggacccagccaacgtggagatcaccgagctctgcattcagcacggctggacc ccaggaaacggtcgcttcgacgtgctgcccctgctgctgcaggccccagatgatccccca gaactcttccttctgccccccgagctggtccttgaggtgcccctggagcaccccacgctg gagtggtttgcagccctgggcctgcgctggtacgccctcccggcagtgtccaacatgctg ctggaaattgggggcctggagttccccgcagcccccttcagtggctggtacatgagcact gagatcggcacgaggaacctgtgtgaccctcaccgctacaacatcctggaggatgtggct gtctgcatggacctggatacccggaccacctcgtccctgtggaaagacaaggcagcagtg gaaatcaacgtggccgtgctgcacagttaccagctagccaaagtcaccatcgtggaccac cacgccgccacggcctctttcatgaagcacctggagaatgagcagaaggccagggggggc tgccctgcagactgggcctggatcgtgccccccatctcgggcagcctcactcctgttttc catcaggagatggtcaactatttcctgtccccggccttccgctaccagccagacccctgg aaggggagtgccgccaagggcaccggcatcaccaggaagaagacctttaaagaagtggcc aacgccgtgaagatctccgcctcgctcatgggcacggtgatggcgaagcgagtgaaggcg acaatcctgtatggctccgagaccggccgggcccagagctacgcacagcagctggggaga ctcttccggaaggcttttgatccccgggtcctgtgtatggatgagtatgacgtggtgtcc ctcgaacacgagacgctggtgctggtggtaaccagcacatttgggaatggggatcccccg gagaatggagagagctttgcagctgccctgatggagatgtccggcccctacaacagctcc cctcggccggaacagcacaagagttataagatccgcttcaacagcatctcctgctcagac ccactggtgtcctcttggcggcggaagaggaaggagtccagtaacacagacagtgcaggg gccctgggcaccctcaggttctgtgtgttcgggctcggctcccgggcatacccccacttc tgcgcctttgctcgtgccgtggacacacggctggaggaactgggcggggagcggctgctg cagctgggccagggcgacgagctgtgcggccaggaggaggccttccgaggctgggcccag gctgccttccaggccgcctgtgagaccttctgtgtgggagaggatgccaaggccgccgcc cgagacatcttcagccccaaacggagctggaagcgccagaggtaccggctgagcgcccag gccgagggcctgcagttgctgccaggtctgatccacgtgcacaggcggaagatgttccag gctacaatccgctcagtggaaaacctgcaaagcagcaagtccacgagggccaccatcctg gtgcgcctggacaccggaggccaggaggggctgcagtaccagccgggggaccacataggt gtctgcccgcccaaccggcccggccttgtggaggcgctgctgagccgcgtggaggacccg ccggcgcccactgagcccgtggcagtagagcagctggagaagggcagccctggtggccct ccccccggctgggtgcgggacccccggctgcccccgtgcacgctgcgccaggctctcacc ttcttcctggacatcacctccccacccagccctcagctcttgcggctgctcagcaccttg gcagaagagcccagggaacagcaggagctggaggccctcagccaggatccccgacgctac gaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccgtcg gtggcgctgcctgccccactgctcctcacccagctgcctctgctccagccccggtactac tcagtcagctcggcacccagcacccacccaggagagatccacctcactgtagctgtgctg gcatacaggactcaggatgggctgggccccctgcactatggagtctgctccacgtggcta agccagctcaagcccggagaccctgtgccctgcttcatccggggggctccctccttccgg ctgccacccgatcccagcttgccctgcatcctggtgggtccaggcactggcattgccccc ttccggggattctggcaggagcggctgcatgacattgagagcaaagggctgcagcccact cccatgactttggtgttcggctgccgatgctcccaacttgaccatctctaccgcgacgag gtgcagaacgcccagcagcgcggggtgtttggccgagtcctcaccgccttctcccgggaa cctgacaaccccaagacctacgtgcaggacatcctgaggacggagctggctgcggaggtg caccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgttaccatggca accaacgtcctgcagaccgtgcagcgcatcctggcgacggagggcgacatggagctggac gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaagacattttc gggctcacgctgcgcacccaggaggtgacaagccgcatacgcacccagagcttttccttg caggagcgtcagttgcggggcgcagtgccctgggcgttcgaccctcccggctcagacacc aacagcccctga

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