KEGG ORTHOLOGY: K09355

ORTHOLOGY: K09355

Entry

K09355                      KO

Symbol

PBX1

Name

pre-B-cell leukemia transcription factor 1

Pathway

map04148

Efferocytosis

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

map05202

Transcriptional misregulation in cancer

Disease

H00001

B-cell acute lymphoblastic leukemia

H01867

Congenital anomalies of kidney and urinary tract

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K09355  PBX1; pre-B-cell leukemia transcription factor 1
09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K09355  PBX1; pre-B-cell leukemia transcription factor 1
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09355  PBX1; pre-B-cell leukemia transcription factor 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09355  PBX1; pre-B-cell leukemia transcription factor 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09355  PBX1; pre-B-cell leukemia transcription factor 1
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain TALE
    K09355  PBX1; pre-B-cell leukemia transcription factor 1

Genes

HSA:	5087(PBX1)

PTR:	457474(PBX1)

PPS:	100990886(PBX1)

GGO:	101150155(PBX1)

PON:	100440755(PBX1)

PPYG:

129033674(PBX1)

NLE:	100591595(PBX1)

HMH:	116473306(PBX1)

SSYN:

134733975(PBX1)

MCC:	694416(PBX1)

MCF:	102132310(PBX1)

MTHB:

126941807

MNI:	105492953(PBX1)

CSAB:

103230699(PBX1)

CATY:

105598271(PBX1)

PANU:

101012778(PBX1)

TGE:	112620982(PBX1)

MLEU:

105552452(PBX1)

RRO:	104670173(PBX1)

RBB:	108538376(PBX1)

TFN:	117076703(PBX1)

PTEH:

111539276(PBX1)

CANG:

105505508(PBX1)

CJC:	100387577(PBX1)

SBQ:	101050091(PBX1)

CIMI:

108308288(PBX1)

ANAN:

105728497(PBX1)

CSYR:

103263561

MMUR:

105868051(PBX1)

LCAT:

123634923(PBX1)

PCOQ:

105806461(PBX1)

OGA:	100942162(PBX1)

MMU:	18514(Pbx1)

MCAL:

110291639(Pbx1)

MPAH:

110321169(Pbx1)

RNO:	304947(Pbx1)

MCOC:

116103106(Pbx1)

ANU:	117716262(Pbx1)

MUN:	110563863(Pbx1)

CGE:	100772263(Pbx1)

MAUA:

101839999(Pbx1)

PROB:

127223541(Pbx1)

PLEU:

114689907(Pbx1)

MORG:

121454881(Pbx1)

MFOT:

126511268

AAMP:

119828025(Pbx1)

NGI:	103746118(Pbx1)

HGL:	101714961(Pbx1)

CPOC:

100723723(Pbx1)

DORD:

105989664(Pbx1)

DSP:	122106064(Pbx1)

PLOP:

125359649(Pbx1)

NCAR:

124961053

MMMA:

107147252(Pbx1)

OCU:

100341186

OPI:	101521634(PBX1)

TUP:	102476678(PBX1)

GVR:	103610237(PBX1)

CFA:	488669(PBX1)

CLUD:

112643068(PBX1)

VVP:	112914311(PBX1)

VLG:	121501740(PBX1)

NPO:	129515224(PBX1)

AML:	100474783(PBX1)

UMR:	103658284(PBX1)

UAH:	113268685(PBX1)

UAR:	123800145(PBX1)

ELK:

111151184

LLV:

125085427

MPUF:

101692430(PBX1)

MNP:	132025736(PBX1)

MLK:	131814516(PBX1)

NVS:	122918397(PBX1)

ORO:	101370420(PBX1)

EJU:	114210504(PBX1)

ZCA:	113932145(PBX1)

MLX:	118014044(PBX1)

NSU:	110588125(PBX1)

LWW:	102728882(PBX1)

FCA:	101081781(PBX1)

PYU:	121020871(PBX1)

PCOO:

112864767(PBX1)

PBG:	122476368(PBX1)

PVIV:

125155009(PBX1)

LRUF:

124509918

PTG:	102968400(PBX1)

PPAD:

109276638(PBX1)

PUC:

125925551

AJU:

106965568

HHV:	120224582(PBX1)

BTA:	540688(PBX1)

BOM:	102275855(PBX1)

BIU:	109577841(PBX1)

BBUB:

102389977(PBX1)

BBIS:

104997300(PBX1)

CHX:	102170836(PBX1)

OAS:	101108880(PBX1)

BTAX:

128044510(PBX1)

ODA:	120855497(PBX1)

CCAD:

122429894(PBX1)

MBEZ:

129541686(PBX1)

SSC:	100154639(PBX1)

CFR:	102517981(PBX1)

CBAI:

105068090(PBX1)

CDK:	105092708(PBX1)

VPC:	102542558(PBX1)

BACU:

103016479(PBX1)

BMUS:

118899060(PBX1)

LVE:	103082318(PBX1)

OOR:	101288266(PBX1)

DLE:	111169236(PBX1)

PCAD:

102983198(PBX1)

PSIU:

116762754(PBX1)

NASI:

112397716(PBX1)

ECB:	100058426(PBX1)

EPZ:	103547337(PBX1)

EAI:	106831135(PBX1)

MYB:	102241711(PBX1)

MYD:	102766693(PBX1)

MMYO:

118672883(PBX1)

MLF:

102436527

MDT:	132220760(PBX1)

PKL:	118721742(PBX1)

EFUS:

103296497(PBX1)

MNA:	107537943(PBX1)

DRO:	112298807(PBX1)

SHON:

118979173(PBX1)

AJM:	119065381(PBX1)

PHAS:

123818382(PBX1)

MMF:	118637565(PBX1)

PPAM:

129082074(PBX1)

HAI:	109392313(PBX1)

RFQ:	117014423(PBX1)

PALE:

102898077(PBX1)

PGIG:

120617498(PBX1)

PVP:	105306027(PBX1)

RAY:	107512725(PBX1)

MJV:	108391167(PBX1)

TOD:	119241352(PBX1)

SARA:

101553756 101555478(PBX1)

SETR:

126013428(PBX1)

LAV:	100658312(PBX1)

TMU:

101356255

ETF:	101661942(PBX1)

DNM:	101425861(PBX1)

MDO:	100016502(PBX1)

GAS:	123247668(PBX1)

SHR:	100928718(PBX1)

AFZ:

127562970

PCW:	110209883(PBX1)

TVP:	118845929(PBX1)

OAA:	100077375(PBX1)

GGA:	395505(PBX1)

PCOC:

116230473(PBX1)

MGP:	100548499(PBX1)

CJO:	107317263(PBX1)

TPAI:

128072142(PBX1)

LMUT:

125693049(PBX1)

NMEL:

110402957(PBX1)

APLA:

101793117(PBX1)

ACYG:

106041605(PBX1)

CATA:

118243540(PBX1)

AFUL:

116491993(PBX1)

TGU:	100231384(PBX1)

LSR:	110478966(PBX1)

SCAN:

103823400(PBX1)

PMOA:

120512179(PBX1)

OTC:	121344234(PBX1)

PRUF:

121359779(PBX1)

GFR:	102033563(PBX1)

FAB:	101809800(PBX1)

OMA:	130255957(PBX1)

PHI:	102114683(PBX1)

PMAJ:

107208314(PBX1)

CCAE:

111932639(PBX1)

CCW:	104695465(PBX1)

CBRC:

103612706(PBX1)

ETL:	114063528(PBX1)

ZAB:	102063324(PBX1)

ZLE:	135450794(PBX1)

ACHL:

103805499

SVG:	106852248(PBX1)

MMEA:

130583565(PBX1)

HRT:	120756447(PBX1)

SATI:

136364751(PBX1)

FPG:	101924009(PBX1)

FCH:	102049171(PBX1)

CCRI:

104161851

NNT:

104412529

SHAB:

115611978(PBX1)

ACUN:

113482945(PBX1)

TALA:

104366673(PBX1)

ACHC:

115348955(PBX1)

HALD:

104318513

HLE:	104840610(PBX1)

AGEN:

GCL:

CSTI:

LDI:

MNB:

DPUB:

104301539(PBX1)

AVIT:

104276874

EGZ:	104132099(PBX1)

NNI:	104010430(PBX1)

PCRI:

104036650

PCAO:

104043310

PADL:

103914110(PBX1)

AFOR:

103893985(PBX1)

FGA:

104073711

GSTE:

104257200(PBX1)

CLV:	102086514(PBX1)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104058354(PBX1)

TEO:

104373484

BREG:

104637979

OHA:	104333744(PBX1)

ACAR:

104526893

CPEA:

104392906(PBX1)

CVF:	104293411(PBX1)

RTD:	128913383(PBX1)

AAM:	106493870(PBX1)

AROW:

112975061(PBX1)

NPD:

112951232

TGT:

104574603

DNE:	112997383(PBX1)

SCAM:

104142737(PBX1)

ASN:	102368257(PBX1)

AMJ:	106737223(PBX1)

CPOO:

109307132(PBX1)

GGN:	109287006(PBX1)

PSS:	102458432(PBX1)

CMY:	102934185(PBX1)

CCAY:

125640942(PBX1)

DCC:	119859978(PBX1)

CPIC:

101948421(PBX2) 101949430(PBX1)

TST:	117882016(PBX1)

CABI:

116839869(PBX1)

MRV:	120370041(PBX1)

ACS:	100567807(pbx1)

ASAO:

132774315(PBX1)

PVT:	110087589(PBX1)

SUND:

121928436(PBX1)

PBI:	103057331(PBX1)

PMUR:

107286310

CTIG:

120299322(PBX1)

TSR:

106556047

PGUT:

117661236(PBX1)

APRI:

131196335(PBX1)

PTEX:

113438155(PBX1)

NSS:

113421682

VKO:	123027977(PBX1)

PMUA:

114598609(PBX1)

PRAF:

128415307(PBX1)

ZVI:	118088715(PBX1)

HCG:	128322615(PBX1)

GJA:

107107275

STOW:

125433747(PBX1)

EMC:	129330024(PBX1)

XLA:	108714419(pbx1.L) 399184(pbx1.S)

XTR:	100216094(pbx1)

NPR:

108789127

RTEM:

120945771

BBUF:

120978675(PBX1)

BGAR:

122943293(PBX1)

MUO:	115471940(PBX1)

GSH:	117367515(PBX1)

DRE:	570960(pbx1b) 58138(pbx1a)

SRX:	107708575 107732204 107745027

SANH:

107677498 107686770 107690813 107700547

SGH:	107554884 107563289 107564502 107567240 107582343 107587951

CCAR:

109048869 109048970 109055794 109063252 109086007 109100678

CAUA:

113045629 113050992 113091272 113115311

CGIB:

127951029 127959880 128015260 128026720

PTET:

122326733(pbx1a) 122347257(pbx1b)

LROH:

127153227(pbx1a) 127167036(pbx1b)

OMC:	131542424(pbx1b) 131553125(pbx1a)

PPRM:

120467947(pbx1b) 120482729(pbx1a)

RKG:	130094474(pbx1a) 130100580(pbx1b)

MAMB:

125250209(pbx1a) 125274088(pbx1b)

CIDE:

127500156 127514529

CERY:

137002751(pbx1a) 137010754(pbx1b)

MASI:

127441403 127442439 127445906 127448679

TROS:

130554695(pbx1a) 130557131(pbx1b)

TDW:	130418073(pbx1a) 130424325(pbx1b)

MANU:

129442466(pbx1a) 129450590(pbx1b)

IPU:	108272157(pbx1b) 108280905(pbx1a)

IFU:	128614673 128623989(pbx1a)

PHYP:

113528896 113546201 113546468

SMEO:

124384629(pbx1b) 124402903(pbx1a)

TFD:	113642970(pbx1b) 113650163(pbx1a)

TVC:	132843948(pbx1a) 132844412(pbx1b)

TRN:	134302307(pbx1a) 134316211(pbx1b)

AMEX:

103025536(pbx1a) 103038228(pbx1b)

CMAO:

118797218(pbx1a) 118808631(pbx1b)

EEE:	113590141 113591044

CHAR:

105895199(pbx1b)

TRU:

101069707

TFS:	130539424(pbx1a)

TNG:	GSTEN00012474G001 GSTEN00028358G001 GSTEN00028359G001

LCO:	104918287 104921741

NCC:	104941252 104964292

TBEN:

117488957 117490970

CGOB:

115006882(pbx1) 115021984

PGEO:

117445417 117463009(pbx1a)

GACU:

117558376(pbx1a) 117559034

EMAC:

134866459(pbx1a) 134870136

ELY:	117253845 117263613(pbx1a)

EFO:	125895551 125902175(pbx1a)

PLEP:

121941021 121951823(pbx1a)

SLUC:

116046074(pbx1a) 116063339(pbx1b)

ECRA:

117949874 117954276(pbx1a)

ESP:	116695584 116699155

PFLV:

114561744 114564779

GAT:	120815770 120823518(pbx1b)

PPUG:

119209376(pbx1a) 119216295

AFB:	129094153 129113423(pbx1a)

CLUM:

117730085(pbx1b) 117746532

PSWI:

130193899 130198050(pbx1a)

MSAM:

119901222 119902085(pbx1a)

SCHU:

122877749 122887045(pbx1a)

CUD:	121512354 121520519(pbx1a)

ALAT:

119010968 119029045(pbx1b)

MZE:	101464457 101471971

ONL:	100695908 100699739 100704482

OAU:	116316977(pbx1a) 116334437(pbx1b)

OLA:	101156808(pbx1) 101160104

OML:	112147407(pbx1a) 112150672

CSAI:

133452729(pbx1a)

XMA:	102217435 102222068

XCO:	114146713 114150981

XHE:	116721813 116726384

PRET:

103463997(pbx1) 103479586

PFOR:

103139833(pbx1) 103143038 103143064

PLAI:

106936233(pbx1) 106962266

PMEI:

106928203(pbx1) 106929027

GAF:	122838489 122841222(pbx1a)

PPRL:

129361897(pbx1a) 129379696

CVG:	107083372 107091547(pbx1)

CTUL:

119786148(pbx1a) 119787696(pbx1b)

GMU:	124869980(pbx1a) 124873835

NFU:	107383950 107387365(pbx1)

KMR:	108239658(pbx1a) 108246256

ALIM:

106529305(pbx1) 106534379

NWH:	119415091(pbx1a) 119430680

AOCE:

111569913 111570137 111579959

MCEP:

125009296 125010753(pbx1a)

CSEM:

103396165

POV:	109625243 109640132

SSEN:

122759906(pbx1b) 122766815(pbx1a)

HHIP:

117759771 117778802(pbx1a)

HSP:	118117285(pbx1a) 118120805

PPLT:

128448522 128455033(pbx1a)

SMAU:

118311493(pbx1a) 118318377

LCF:	108878920 108883449(pbx1a)

SDU:	111231978 111239007

SLAL:

111653533 111662587

XGL:	120790844 120798852(pbx1a)

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

109957687 109965731(pbx1)

BSPL:

114844734(pbx1a) 114853505(pbx1b)

SJO:	128361443 128368598(pbx1a)

SASA:

106560332 106569198 106584178 106599262

STRU:

115157098 115158599 115169676 115192319

OTW:	112226864 112249900(pbx1b) 112251267 112260542

OMY:	110508658 110520992 110524620 110530398

OGO:	123996754 124009514 124037904 124041799

ONE:	115103020 115108583 115114485 115145192

OKI:	109871867 109874941 109898075 109902767

OKE:	118358980 118372991 118394736 118402036

SALP:

111956757 111972375 111979232 112070953

SNH:	120020404 120052622(pbx1b) 120054545 120055906

CCLU:

121533909 121535286 121540504 121580977

ELS:	105011758 105019125

SFM:

108923829

PKI:	111846477 111849160

AANG:

118225863(pbx1b) 118229784

LOC:

PSPA:

ARUT:

PSEX:

LCM:	102366427(PBX1)

CMK:

103184810

RTP:

109931724

CPLA:

122548313 122552150

HOC:	132818645 132836048(pbx4)

LERI:

129701058 129714446(pbx4)

PMRN:

116945009 116953203 116955290

LRJ:	133341875 133354652

BBEL:

109482458

CIN:	778982(pbx)

APLC:

110988573

AJC:

117118600

DME:	Dmel_CG8933(exd)

DER:

6550664

DSE:

6620724

DSI:	Dsimw501_GD17261(Dsim_GD17261)

DYA:	Dyak_GE17244

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16078

DAZ:

108619333

DNV:

108656832

DHE:

111604917

DVI:	6634793 6634831

CCAT:

BOD:

BDR:

AOQ:

TDA:	119666461 119669400

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008038 CpipJ_CPIJ008039 CpipJ_CPIJ018733

CPII:

120428352

CNS:	116341578 116342309

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100121307 100123119

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	641540(Exd)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:	108913142 108915832

LDC:

111502025

DVV:

114342549

NVL:	108568946 108569069 108569572

DCOR:

135801355(exd)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208840

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103509532 103519393

CLEC:

106668149

HHAL:

106687148(exd)

NLU:

111058456

MQU:

128991608

PHU:	Phum_PHUM213170

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_347218(EXD)

DMK:

116927944

DPZ:

124315361

PVM:	113805165 113805566

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111696094 111696095 111709486

LSM:	121128534 121130403

TCF:	131877047 131889105 131889638

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136973753 136979666

PTEP:

107439046 107449226

ABRU:

129980579 129983799

UDV:	129222359 129224319

SDM:	118188222 118189019

LPOL:

106456992 106457186 106466577 106468114 106475489

PMEO:

129584143 129589412

CEL:	CELE_F17A2.5(ceh-40) CELE_F31E3.1(ceh-20)

CBR:	CBG_05292 CBG_16494(Cbr-ceh-20)

CRQ:	GCK72_009939 GCK72_025423

NAI:	NECAME_04423

BMY:	BM_BM3730(Bm3730)

LOA:	LOAG_05520

TSP:

Tsp_00508

HRO:	HELRODRAFT_185992 HELRODRAFT_195013 HELRODRAFT_87471

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_126030

SHX:	MS3_00009842(PBX3)

OVI:	T265_00694

LLON:

135501120

NVE:

5515299

EPA:	110244789 110244790

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130612065 130612214

TAD:	TRIADDRAFT_21171

ACAN:

ACA1_117000

» show all

Reference

PMID:18033668

Authors

Laurent A, Bihan R, Omilli F, Deschamps S, Pellerin I

Title

PBX proteins: much more than Hox cofactors.

Journal

Int J Dev Biol 52:9-20 (2008)
DOI:10.1387/ijdb.072304al

Reference

PMID:11267683

Authors

Thameem F, Wolford JK, Bogardus C, Prochazka M

Title

Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians.

Journal

Biochim Biophys Acta 1518:215-20 (2001)
DOI:10.1016/S0167-4781(01)00189-0

Sequence

[hsa:5087]

LinkDB

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