KEGG   Homo sapiens (human): 5347
Entry
5347              CDS       T01001                                 
Symbol
PLK1, PLK, STPK13
Name
(RefSeq) polo like kinase 1
  KO
K06631  polo-like kinase 1 [EC:2.7.11.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
Network
nt06512  Chromosome cohesion and segregation
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01562  Microtubule depolymerization at the minus ends
Drug target
Onvansertib (DG03017): D11458 D11459
Rigosertib (DG01416): D10154 D10155
Volasertib (DG01417): D10182 D10183
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    5347 (PLK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    5347 (PLK1)
   04114 Oocyte meiosis
    5347 (PLK1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    5347 (PLK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5347 (PLK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5347 (PLK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.21  polo kinase
     5347 (PLK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PLK family [OT]
   5347 (PLK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     5347 (PLK1)
  Centrosome formation proteins
   Kinases and associated factors
    5347 (PLK1)
  Sister chromatid separation proteins
   Polo kinases
    5347 (PLK1)
SSDB
Motif
Pfam: Pkinase POLO_box PK_Tyr_Ser-Thr Kinase-like Pkinase_fungal ABC1 APH
Other DBs
NCBI-GeneID: 5347
NCBI-ProteinID: NP_005021
OMIM: 602098
HGNC: 9077
Ensembl: ENSG00000166851
UniProt: P53350
Structure
LinkDB
Position
16:23678889..23690367
AA seq 603 aa
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
NT seq 1812 nt   +upstreamnt  +downstreamnt
atgagtgctgcagtgactgcagggaagctggcacgggcaccggccgaccctgggaaagcc
ggggtccccggagttgcagctcccggagctccggcggcggctccaccggcgaaagagatc
ccggaggtcctagtggacccacgcagccggcggcgctatgtgcggggccgctttttgggc
aagggcggctttgccaagtgcttcgagatctcggacgcggacaccaaggaggtgttcgcg
ggcaagattgtgcctaagtctctgctgctcaagccgcaccagagggagaagatgtccatg
gaaatatccattcaccgcagcctcgcccaccagcacgtcgtaggattccacggctttttc
gaggacaacgacttcgtgttcgtggtgttggagctctgccgccggaggtctctcctggag
ctgcacaagaggaggaaagccctgactgagcctgaggcccgatactacctacggcaaatt
gtgcttggctgccagtacctgcaccgaaaccgagttattcatcgagacctcaagctgggc
aaccttttcctgaatgaagatctggaggtgaaaataggggattttggactggcaaccaaa
gtcgaatatgacggggagaggaagaagaccctgtgtgggactcctaattacatagctccc
gaggtgctgagcaagaaagggcacagtttcgaggtggatgtgtggtccattgggtgtatc
atgtataccttgttagtgggcaaaccaccttttgagacttcttgcctaaaagagacctac
ctccggatcaagaagaatgaatacagtattcccaagcacatcaaccccgtggccgcctcc
ctcatccagaagatgcttcagacagatcccactgcccgcccaaccattaacgagctgctt
aatgacgagttctttacttctggctatatccctgcccgtctccccatcacctgcctgacc
attccaccaaggttttcgattgctcccagcagcctggaccccagcaaccggaagcccctc
acagtcctcaataaaggcttggagaaccccctgcctgagcgtccccgggaaaaagaagaa
ccagtggttcgagagacaggtgaggtggtcgactgccacctcagtgacatgctgcagcag
ctgcacagtgtcaatgcctccaagccctcggagcgtgggctggtcaggcaagaggaggct
gaggatcctgcctgcatccccatcttctgggtcagcaagtgggtggactattcggacaag
tacggccttgggtatcagctctgtgataacagcgtgggggtgctcttcaatgactcaaca
cgcctcatcctctacaatgatggtgacagcctgcagtacatagagcgtgacggcactgag
tcctacctcaccgtgagttcccatcccaactccttgatgaagaagatcaccctccttaaa
tatttccgcaattacatgagcgagcacttgctgaaggcaggtgccaacatcacgccgcgc
gaaggtgatgagctcgcccggctgccctacctacggacctggttccgcacccgcagcgcc
atcatcctgcacctcagcaacggcagcgtgcagatcaacttcttccaggatcacaccaag
ctcatcttgtgcccactgatggcagccgtgacctacatcgacgagaagcgggacttccgc
acataccgcctgagtctcctggaggagtacggctgctgcaaggagctggccagccggctc
cgctacgcccgcactatggtggacaagctgctgagctcacgctcggccagcaaccgtctc
aaggcctcctaa

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