KEGG   NETWORK: N01471
Entry
N01471                      Network                                
Name
Origin unwinding and elongation
Definition
CMG+POLE+MCM10 == POLA+PRIM == RPA -> CMG+MCM10+CTF4+POLA+POLE == RFC+PCNA
  Expanded
8318+4171+4172+4173+4174+4175+4176+9837+51659+64785+84296+5426+5427+54107+56655+55388 == 5422+23649+5557+5558 == 6117+6118+6119 -> 8318+4171+4172+4173+4174+4175+4176+9837+51659+64785+84296+55388+11169+5422+23649+5557+5558+5426+5427+54107+56655 == 5981+5982+5983+5984+5985+5111
Class
nt06509 DNA replication
Type
Reference
Pathway
hsa04110  Cell cycle
hsa03030  DNA replication
Gene
8318  CDC45; cell division cycle 45
4171  MCM2; minichromosome maintenance complex component 2
4172  MCM3; minichromosome maintenance complex component 3
4173  MCM4; minichromosome maintenance complex component 4
4174  MCM5; minichromosome maintenance complex component 5
4175  MCM6; minichromosome maintenance complex component 6
4176  MCM7; minichromosome maintenance complex component 7
9837  GINS1; GINS complex subunit 1
51659  GINS2; GINS complex subunit 2
64785  GINS3; GINS complex subunit 3
84296  GINS4; GINS complex subunit 4
5426  POLE; DNA polymerase epsilon, catalytic subunit
5427  POLE2; DNA polymerase epsilon 2, accessory subunit
54107  POLE3; DNA polymerase epsilon 3, accessory subunit
56655  POLE4; DNA polymerase epsilon 4, accessory subunit
55388  MCM10; minichromosome maintenance 10 replication initiation factor
5422  POLA1; DNA polymerase alpha 1, catalytic subunit
23649  POLA2; DNA polymerase alpha 2, accessory subunit
5557  PRIM1; DNA primase subunit 1
5558  PRIM2; DNA primase subunit 2
6117  RPA1; replication protein A1
6118  RPA2; replication protein A2
6119  RPA3; replication protein A3
11169  WDHD1; WD repeat and HMG-box DNA binding protein 1
5981  RFC1; replication factor C subunit 1
5982  RFC2; replication factor C subunit 2
5983  RFC3; replication factor C subunit 3
5984  RFC4; replication factor C subunit 4
5985  RFC5; replication factor C subunit 5
5111  PCNA; proliferating cell nuclear antigen
Reference
PMID:35741449
  Authors
Tanaka S, Ogawa S
  Title
Dimerization of Firing Factors for Replication Origin Activation in Eukaryotes: A Crucial Process for Simultaneous Assembly of Bidirectional Replication Forks?
  Journal
Biology (Basel) 11:928 (2022)
DOI:10.3390/biology11060928
Reference
PMID:23332289
  Authors
Thu YM, Bielinsky AK
  Title
Enigmatic roles of Mcm10 in DNA replication.
  Journal
Trends Biochem Sci 38:184-94 (2013)
DOI:10.1016/j.tibs.2012.12.003
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