Entry |
|
Symbol |
PPP3CA, ACCIID, CALN, CALNA, CALNA1, CCN1, CNA1, DEE91, IECEE, IECEE1, PPP2B
|
Name |
(RefSeq) protein phosphatase 3 catalytic subunit alpha
|
KO |
K04348 | serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] |
|
Organism |
|
Pathway |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04660 | T cell receptor signaling pathway |
hsa04662 | B cell receptor signaling pathway |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05163 | Human cytomegalovirus infection |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Network |
nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus 1 (HIV-1) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06167 Human cytomegalovirus (HCMV) nt06220 Calcium signaling (cancer) nt06528 Calcium signaling nt06537 TCR/BCR signaling |
Element |
N00147 | EGF-EGFR-PLCG-calcineurin signaling pathway |
N00401 | CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway |
N00487 | BCR-PLCG-Calcineurin signaling pathway |
N01647 | Ca2+/CAM-CN signaling pathway |
|
Disease |
H00606 | Early infantile epileptic encephalopathy |
H02150 | Infantile or early childhood epileptic encephalopathy |
H02641 | Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5530 (PPP3CA)
04310 Wnt signaling pathway
5530 (PPP3CA)
04370 VEGF signaling pathway
5530 (PPP3CA)
04020 Calcium signaling pathway
5530 (PPP3CA)
04022 cGMP-PKG signaling pathway
5530 (PPP3CA)
09140 Cellular Processes
09143 Cell growth and death
04114 Oocyte meiosis
5530 (PPP3CA)
04218 Cellular senescence
5530 (PPP3CA)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
5530 (PPP3CA)
04650 Natural killer cell mediated cytotoxicity
5530 (PPP3CA)
04660 T cell receptor signaling pathway
5530 (PPP3CA)
04658 Th1 and Th2 cell differentiation
5530 (PPP3CA)
04659 Th17 cell differentiation
5530 (PPP3CA)
04662 B cell receptor signaling pathway
5530 (PPP3CA)
09152 Endocrine system
04922 Glucagon signaling pathway
5530 (PPP3CA)
04921 Oxytocin signaling pathway
5530 (PPP3CA)
04924 Renin secretion
5530 (PPP3CA)
09156 Nervous system
04724 Glutamatergic synapse
5530 (PPP3CA)
04728 Dopaminergic synapse
5530 (PPP3CA)
04720 Long-term potentiation
5530 (PPP3CA)
09158 Development and regeneration
04360 Axon guidance
5530 (PPP3CA)
04380 Osteoclast differentiation
5530 (PPP3CA)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5530 (PPP3CA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5530 (PPP3CA)
05170 Human immunodeficiency virus 1 infection
5530 (PPP3CA)
05163 Human cytomegalovirus infection
5530 (PPP3CA)
05167 Kaposi sarcoma-associated herpesvirus infection
5530 (PPP3CA)
09171 Infectious disease: bacterial
05152 Tuberculosis
5530 (PPP3CA)
09164 Neurodegenerative disease
05010 Alzheimer disease
5530 (PPP3CA)
05014 Amyotrophic lateral sclerosis
5530 (PPP3CA)
05020 Prion disease
5530 (PPP3CA)
05022 Pathways of neurodegeneration - multiple diseases
5530 (PPP3CA)
09165 Substance dependence
05031 Amphetamine addiction
5530 (PPP3CA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5530 (PPP3CA)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5530 (PPP3CA)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.16 protein-serine/threonine phosphatase
5530 (PPP3CA)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Calcineurin (PPP3/ PP2B)
Catalytic subunits
5530 (PPP3CA)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
4:complement(101023418..101347526)
|
AA seq |
521 aa
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ |
NT seq |
1566 nt +upstreamnt +downstreamnt
atgtccgagcccaaggcaattgatcccaagttgtcgacgaccgacagggtggtgaaagct
gttccatttcctccaagtcaccggcttacagcaaaagaagtgtttgataatgatggaaaa
cctcgtgtggatatcttaaaggcgcatcttatgaaggagggaaggctggaagagagtgtt
gcattgagaataataacagagggtgcatcaattcttcgacaggaaaaaaatttgctggat
attgatgcgccagtcactgtttgtggggacattcatggacaattctttgatttgatgaag
ctctttgaagtcgggggatctcctgccaacactcgctacctcttcttaggggactatgtt
gacagagggtacttcagtattgaatgtgtgctgtatttgtgggccttgaaaattctctac
cccaaaacactgtttttacttcgtggaaatcatgaatgtagacatctaacagagtatttc
acatttaaacaagaatgtaaaataaagtattcagaacgcgtatatgatgcctgtatggat
gcctttgactgccttcccctggctgccctgatgaaccaacagttcctgtgtgtgcatggt
ggtttgtctccagagattaacactttagatgatatcagaaaattagaccgattcaaagaa
ccacctgcatatggacctatgtgtgatatcctgtggtcagaccccctggaagattttgga
aatgagaagactcaggaacatttcactcacaacacagtcagggggtgttcatacttctac
agttacccggctgtatgtgaattcttacagcacaataacttgttatctatactccgagcc
cacgaagcccaagatgcagggtaccgcatgtacaggaaaagccaaacaacaggcttccct
tctctaattacaattttttcagcaccaaattacttagatgtatacaataacaaagctgca
gtattgaagtatgagaacaatgttatgaatatcaggcaattcaactgttctcctcatcca
tactggcttccaaatttcatggatgtttttacttggtcccttccatttgttggggaaaaa
gtgactgagatgctggtaaatgtcctcaacatctgctcagatgatgaactagggtcagaa
gaagatggatttgatggtgcaacagctgcagcccggaaagaggtgataaggaacaagatc
cgagcaataggcaaaatggccagagtgttctcagtgctcagagaagagagtgagagtgtg
ctgacgctgaaaggcttgaccccaactggcatgctccccagcggagtactttctggaggg
aagcaaaccctgcaaagcgctactgttgaggctattgaggctgatgaagctatcaaagga
ttttcaccacaacataagatcactagcttcgaggaagccaagggcttagaccgaattaat
gagaggatgccgcctcgcagagatgccatgccctctgacgccaaccttaactccatcaac
aaggctctcacctcagagactaacggcacggacagcaatggcagtaatagcagcaatatt
cagtga |