KEGG   NETWORK: N00487
Entry
N00487                      Network                                
Name
BCR-PLCG-Calcineurin signaling pathway
Definition
IGH -> (LYN,SYK) -> (BTK,BLNK) -> PLCG2 -> IP3 -> Ca2+ -> CALM == CN -> NFAT
  Expanded
102723407 -> (4067,6850) -> (695,29760) -> 5336 -> C01245 -> C00076 -> (801,805,808) == (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06537 TCR/BCR signaling
nt06220 Calcium signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04662  B cell receptor signaling pathway
Gene
102723407  IGH; immunoglobulin heavy variable 4-38-2-like
4067  LYN; LYN proto-oncogene, Src family tyrosine kinase
6850  SYK; spleen associated tyrosine kinase
695  BTK; Bruton tyrosine kinase
29760  BLNK; B cell linker
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T cells 1
4773  NFATC2; nuclear factor of activated T cells 2
4775  NFATC3; nuclear factor of activated T cells 3
4776  NFATC4; nuclear factor of activated T cells 4
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:27101923
  Authors
Moens L, Kane A, Tangye SG
  Title
Naive and memory B cells exhibit distinct biochemical responses following BCR engagement.
  Journal
Immunol Cell Biol 94:774-86 (2016)
DOI:10.1038/icb.2016.41
Reference
PMID:26227856
  Authors
Bojarczuk K, Bobrowicz M, Dwojak M, Miazek N, Zapala P, Bunes A, Siernicka M, Rozanska M, Winiarska M
  Title
B-cell receptor signaling in the pathogenesis of lymphoid malignancies.
  Journal
Blood Cells Mol Dis 55:255-65 (2015)
DOI:10.1016/j.bcmd.2015.06.016
Reference
PMID:23886342
  Authors
Puri KD, Di Paolo JA, Gold MR
  Title
B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.
  Journal
Int Rev Immunol 32:397-427 (2013)
DOI:10.3109/08830185.2013.818140
Reference
PMID:22000665
  Authors
Baba Y, Kurosaki T
  Title
Impact of Ca2+ signaling on B cell function.
  Journal
Trends Immunol 32:589-94 (2011)
DOI:10.1016/j.it.2011.09.004
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