| Entry |
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| Name |
EGF-EGFR-PLCG-calcineurin signaling pathway
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| Definition |
EGF -> EGFR -> PLCG -> IP3 -> Ca2+ -> CALM == CN -> NFAT |
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| Expanded |
1950 -> 1956 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) == (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776) |
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| Class |
nt06220 Calcium signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
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| Type |
Reference
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| Pathway |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 1956 | EGFR; epidermal growth factor receptor |
| 5335 | PLCG1; phospholipase C gamma 1 |
| 5336 | PLCG2; phospholipase C gamma 2 |
| 5530 | PPP3CA; protein phosphatase 3 catalytic subunit alpha |
| 5532 | PPP3CB; protein phosphatase 3 catalytic subunit beta |
| 5533 | PPP3CC; protein phosphatase 3 catalytic subunit gamma |
| 5534 | PPP3R1; protein phosphatase 3 regulatory subunit B, alpha |
| 5535 | PPP3R2; protein phosphatase 3 regulatory subunit B, beta |
| 4772 | NFATC1; nuclear factor of activated T-cells 1 |
| 4773 | NFATC2; nuclear factor of activated T-cells 2 |
| 4775 | NFATC3; nuclear factor of activated T-cells 3 |
| 4776 | NFATC4; nuclear factor of activated T-cells 4 |
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| Metabolite |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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| Reference |
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| Authors |
Roderick HL, Cook SJ |
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| Title |
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. |
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| Journal |
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| Reference |
|
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| Authors |
Slusarski DC, Pelegri F |
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| Title |
Calcium signaling in vertebrate embryonic patterning and morphogenesis. |
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| Journal |
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| LinkDB |
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