Entry
Symbol
PPP3CA, ACCIID, CALN, CALNA, CALNA1, CCN1, CNA1, DEE91, IECEE, IECEE1, PPP2B
Name
(RefSeq) protein phosphatase 3 catalytic subunit alpha
KO
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16 ]
Organism
Pathway
hsa04625 C-type lectin receptor signaling pathway
hsa04650 Natural killer cell mediated cytotoxicity
hsa04658 Th1 and Th2 cell differentiation
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa05022 Pathways of neurodegeneration - multiple diseases
hsa05163 Human cytomegalovirus infection
hsa05166 Human T-cell leukemia virus 1 infection
hsa05167 Kaposi sarcoma-associated herpesvirus infection
hsa05170 Human immunodeficiency virus 1 infection
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
nt06167 Human cytomegalovirus (HCMV)
nt06220 Calcium signaling (cancer)
nt06528 Calcium signaling
nt06537 TCR/BCR signaling
Element
N00147 EGF-EGFR-PLCG-calcineurin signaling pathway
N00401 CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
N00487 BCR-PLCG-Calcineurin signaling pathway
N01647 Ca2+/CAM-CN signaling pathway
Disease
H00606 Early infantile epileptic encephalopathy
H02150 Infantile or early childhood epileptic encephalopathy
H02641 Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development
Drug target
Brite
KEGG Orthology (KO) [BR:hsa00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
5530 (PPP3CA)
04022 cGMP-PKG signaling pathway
5530 (PPP3CA)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
5530 (PPP3CA)
04660 T cell receptor signaling pathway
5530 (PPP3CA)
04658 Th1 and Th2 cell differentiation
5530 (PPP3CA)
04659 Th17 cell differentiation
5530 (PPP3CA)
04662 B cell receptor signaling pathway
5530 (PPP3CA)
09152 Endocrine system
04922 Glucagon signaling pathway
5530 (PPP3CA)
04921 Oxytocin signaling pathway
5530 (PPP3CA)
04924 Renin secretion
5530 (PPP3CA)
09156 Nervous system
04724 Glutamatergic synapse
5530 (PPP3CA)
04728 Dopaminergic synapse
5530 (PPP3CA)
04720 Long-term potentiation
5530 (PPP3CA)
09158 Development and regeneration
04360 Axon guidance
5530 (PPP3CA)
04380 Osteoclast differentiation
5530 (PPP3CA)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5530 (PPP3CA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5530 (PPP3CA)
05170 Human immunodeficiency virus 1 infection
5530 (PPP3CA)
05163 Human cytomegalovirus infection
5530 (PPP3CA)
05167 Kaposi sarcoma-associated herpesvirus infection
5530 (PPP3CA)
09171 Infectious disease: bacterial
05152 Tuberculosis
5530 (PPP3CA)
09164 Neurodegenerative disease
05010 Alzheimer disease
5530 (PPP3CA)
05014 Amyotrophic lateral sclerosis
5530 (PPP3CA)
05020 Prion disease
5530 (PPP3CA)
05022 Pathways of neurodegeneration - multiple diseases
5530 (PPP3CA)
09165 Substance dependence
05031 Amphetamine addiction
5530 (PPP3CA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5530 (PPP3CA)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:hsa01009 ]
5530 (PPP3CA)
Enzymes [BR:hsa01000 ]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.16 protein-serine/threonine phosphatase
5530 (PPP3CA)
Protein phosphatases and associated proteins [BR:hsa01009 ]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Calcineurin (PPP3/ PP2B)
Catalytic subunits
5530 (PPP3CA)
BRITE hierarchy
SSDB
Ortholog Paralog Gene cluster GFIT
Motif
Motif
Other DBs
Structure
PDB PDBj
LinkDB
All DBs
Position
4:complement(101023418..101347526)
Genome browser
AA seq
521 aa AA seq DB search
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
NT seq
1566 nt NT seq +upstream nt +downstream nt
atgtccgagcccaaggcaattgatcccaagttgtcgacgaccgacagggtggtgaaagct
gttccatttcctccaagtcaccggcttacagcaaaagaagtgtttgataatgatggaaaa
cctcgtgtggatatcttaaaggcgcatcttatgaaggagggaaggctggaagagagtgtt
gcattgagaataataacagagggtgcatcaattcttcgacaggaaaaaaatttgctggat
attgatgcgccagtcactgtttgtggggacattcatggacaattctttgatttgatgaag
ctctttgaagtcgggggatctcctgccaacactcgctacctcttcttaggggactatgtt
gacagagggtacttcagtattgaatgtgtgctgtatttgtgggccttgaaaattctctac
cccaaaacactgtttttacttcgtggaaatcatgaatgtagacatctaacagagtatttc
acatttaaacaagaatgtaaaataaagtattcagaacgcgtatatgatgcctgtatggat
gcctttgactgccttcccctggctgccctgatgaaccaacagttcctgtgtgtgcatggt
ggtttgtctccagagattaacactttagatgatatcagaaaattagaccgattcaaagaa
ccacctgcatatggacctatgtgtgatatcctgtggtcagaccccctggaagattttgga
aatgagaagactcaggaacatttcactcacaacacagtcagggggtgttcatacttctac
agttacccggctgtatgtgaattcttacagcacaataacttgttatctatactccgagcc
cacgaagcccaagatgcagggtaccgcatgtacaggaaaagccaaacaacaggcttccct
tctctaattacaattttttcagcaccaaattacttagatgtatacaataacaaagctgca
gtattgaagtatgagaacaatgttatgaatatcaggcaattcaactgttctcctcatcca
tactggcttccaaatttcatggatgtttttacttggtcccttccatttgttggggaaaaa
gtgactgagatgctggtaaatgtcctcaacatctgctcagatgatgaactagggtcagaa
gaagatggatttgatggtgcaacagctgcagcccggaaagaggtgataaggaacaagatc
cgagcaataggcaaaatggccagagtgttctcagtgctcagagaagagagtgagagtgtg
ctgacgctgaaaggcttgaccccaactggcatgctccccagcggagtactttctggaggg
aagcaaaccctgcaaagcgctactgttgaggctattgaggctgatgaagctatcaaagga
ttttcaccacaacataagatcactagcttcgaggaagccaagggcttagaccgaattaat
gagaggatgccgcctcgcagagatgccatgccctctgacgccaaccttaactccatcaac
aaggctctcacctcagagactaacggcacggacagcaatggcagtaatagcagcaatatt
cagtga