KEGG   Homo sapiens (human): 5573
Entry
5573              CDS       T01001                                 
Symbol
PRKAR1A, ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, Prkar1alpha, TSE1
Name
(RefSeq) protein kinase cAMP-dependent type I regulatory subunit alpha
  KO
K04739  cAMP-dependent protein kinase regulator
Organism
hsa  Homo sapiens (human)
Pathway
hsa04910  Insulin signaling pathway
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N01542  PKA holoenzyme
Disease
H00260  Pigmented micronodular adrenocortical disease
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01820  Carney complex
H02211  Acrodysostosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    5573 (PRKAR1A)
SSDB
Motif
Pfam: cNMP_binding RIIa
Other DBs
NCBI-GeneID: 5573
NCBI-ProteinID: NP_001263218
OMIM: 188830
HGNC: 9388
Ensembl: ENSG00000108946
UniProt: P10644 B2R5T5
Structure
LinkDB
Position
17:68413623..68551316
AA seq 381 aa
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSDILKRNIQQYNSFVSLSV
NT seq 1146 nt   +upstreamnt  +downstreamnt
atggagtctggcagtaccgccgccagtgaggaggcacgcagccttcgagaatgtgagctc
tacgtccagaagcataacattcaagcgctgctcaaagattctattgtgcagttgtgcact
gctcgacctgagagacccatggcattcctcagggaatactttgagaggttggagaaggag
gaggcaaaacagattcagaatctgcagaaagcaggcactcgtacagactcaagggaggat
gagatttctcctcctccacccaacccagtggttaaaggtaggaggcgacgaggtgctatc
agcgctgaggtctacacggaggaagatgcggcatcctatgttagaaaggttataccaaaa
gattacaagacaatggccgctttagccaaagccattgaaaagaatgtgctgttttcacat
cttgatgataatgagagaagtgatatttttgatgccatgttttcggtctcctttatcgca
ggagagactgtgattcagcaaggtgatgaaggggataacttctatgtgattgatcaagga
gagacggatgtctatgttaacaatgaatgggcaaccagtgttggggaaggagggagcttt
ggagaacttgctttgatttatggaacaccgagagcagccactgtcaaagcaaagacaaat
gtgaaattgtggggcatcgaccgagacagctatagaagaatcctcatgggaagcacactg
agaaagcggaagatgtatgaggaattccttagtaaagtctctattttagagtctctggac
aagtgggaacgtcttacggtagctgatgcattggaaccagtgcagtttgaagatgggcag
aagattgtggtgcagggagaaccaggggatgagttcttcattattttagaggggtcagct
gctgtgctacaacgtcggtcagaaaatgaagagtttgttgaagtgggaagattggggcct
tctgattattttggtgaaattgcactactgatgaatcgtcctcgtgctgccacagttgtt
gctcgtggccccttgaagtgcgttaagctggaccgacctagatttgaacgtgttcttggc
ccatgctcagacatcctcaaacgaaacatccagcagtacaacagttttgtgtcactgtct
gtctga

KEGG   Homo sapiens (human): 5576
Entry
5576              CDS       T01001                                 
Symbol
PRKAR2A, PKR2, PRKAR2
Name
(RefSeq) protein kinase cAMP-dependent type II regulatory subunit alpha
  KO
K04739  cAMP-dependent protein kinase regulator
Organism
hsa  Homo sapiens (human)
Pathway
hsa04910  Insulin signaling pathway
Network
nt06310  CRH-ACTH-cortisol signaling
  Element
N01542  PKA holoenzyme
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    5576 (PRKAR2A)
SSDB
Motif
Pfam: cNMP_binding RIIa
Other DBs
NCBI-GeneID: 5576
NCBI-ProteinID: NP_001308911
OMIM: 176910
HGNC: 9391
Ensembl: ENSG00000114302
UniProt: P13861 A0A024R2W3 A8KAH7
Structure
LinkDB
Position
3:complement(48744591..48847874)
AA seq 404 aa
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLG
HPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIH
PKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIE
RGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI
IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYI
IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCL
VMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ
NT seq 1215 nt   +upstreamnt  +downstreamnt
atgagccacatccagatcccgccggggctcacggagctgctgcagggctacacggtggag
gtgctgcgacagcagccgcctgacctcgtcgaattcgcagtggagtacttcacccgcctg
cgcgaggcccgcgccccagcctcagtcctgcccgccgccaccccacgccagagcctgggc
caccccccgccagaacccggcccggaccgtgtcgccgacgccaaaggggacagcgagtcg
gaggaggacgaggacttggaagttccagttcctagcagatttaatagacgagtatcagtc
tgtgctgagacctataaccctgatgaggaagaggaagatacagatccaagggtgattcat
cctaaaactgatgaacagagatgcagacttcaggaagcttgcaaagatattctccttttc
aaaaatcttgatcaggaacagctttctcaagttctcgatgccatgtttgaaaggatagtc
aaagctgatgagcatgtcattgaccaaggagatgatggagacaacttttatgtcatagaa
cggggaacttatgacattttagtaacaaaagataatcaaacccgctctgttggtcaatat
gacaaccgtggcagttttggagaactagctctgatgtacaacaccccgagagctgctacc
attgttgctacctcagaaggctccctttggggactggaccgggtgacttttagaagaatc
atagtgaaaaataatgcaaagaagaggaagatgtttgaatcatttattgagtctgtgccc
ctccttaaatcactagaggtgtcagaacgaatgaagattgtggatgtaataggagagaag
atctataaggatggagaacgcataatcactcagggtgaaaaggctgatagcttttacatc
atagagtctggcgaagtgagcatcttgattagaagcaggactaaatcaaacaaggatggt
gggaaccaggaggtcgagattgcccgctgccataaggggcagtactttggagagcttgcc
ctggtcaccaacaaacccagagctgcctcagcttatgcagttggagatgtcaaatgctta
gttatggatgtacaagcattcgagaggcttctggggccctgcatggacatcatgaagagg
aacatctcacactatgaggaacagctggtgaagatgtttggctccagcgtggatctgggc
aacctcgggcagtag

KEGG   Homo sapiens (human): 5575
Entry
5575              CDS       T01001                                 
Symbol
PRKAR1B, MASNS, PRKAR1
Name
(RefSeq) protein kinase cAMP-dependent type I regulatory subunit beta
  KO
K04739  cAMP-dependent protein kinase regulator
Organism
hsa  Homo sapiens (human)
Pathway
hsa04910  Insulin signaling pathway
Network
nt06310  CRH-ACTH-cortisol signaling
  Element
N01542  PKA holoenzyme
Disease
H02728  Marbach-Schaaf neurodevelopmental syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    5575 (PRKAR1B)
SSDB
Motif
Pfam: cNMP_binding RIIa
Other DBs
NCBI-GeneID: 5575
NCBI-ProteinID: NP_001158230
OMIM: 176911
HGNC: 9390
Ensembl: ENSG00000188191
UniProt: P31321
Structure
LinkDB
Position
7:complement(549197..728934)
AA seq 381 aa
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE
ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK
DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL
RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA
SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSEILKRNIQRYNSFISLTV
NT seq 1146 nt   +upstreamnt  +downstreamnt
atggcctccccgcccgcctgcccctcggaggaggacgagagcctgaagggctgtgagctg
tacgtgcagctgcacgggatccagcaggtcctcaaagactgtatcgtccacctctgcatc
tccaagcccgaacgccccatgaagttcctccgggagcacttcgagaagctggagaaggaa
gaaaacaggcagattttggcgcggcaaaagtcaaactcacagtcggactcccatgatgag
gaggtgtcgcccacccccccgaaccctgtggtgaaggcccgccgccggcgaggaggcgtg
agtgccgaggtgtacaccgaggaggacgccgtgtcctacgtcaggaaggtgattcccaag
gactacaaaaccatgactgcgctggccaaggccatctccaagaacgtgctcttcgctcac
ctggatgacaacgagaggagtgacatattcgatgccatgttccctgtcactcacatcgct
ggggagactgttatacagcaagggaatgaaggagacaacttctatgtcgttgatcaaggg
gaagtggatgtgtacgtgaacggagagtgggtgaccaacatcagcgagggaggcagcttc
ggggagctggcgctcatctacggcacccccagggctgcgaccgtgaaagccaagacggac
ctcaagctctgggggatcgaccgggacagctaccggcgcatccttatgggcagcacgctg
aggaaacgcaagatgtacgaggagttcctcagcaaggtctccatcctagagtccctggag
aagtgggagcgtctgaccgtggcggatgcgctggagcccgtccagtttgaagatggagag
aaaattgtggtccagggagagcctggggacgacttttacatcatcacggagggcaccgcg
tccgtgctgcagcgccggtcccccaatgaggagtacgtggaggtggggcgcctgggaccc
tctgactacttcggggagattgcactgctgctgaaccggccccgggcggccactgtcgtg
gcccgggggcccctcaagtgtgtgaagctggaccggccccgcttcgagcgtgtgctgggg
ccctgctctgagatcctcaagaggaacattcagcgttacaacagcttcatctccctcacc
gtctga

KEGG   Homo sapiens (human): 5577
Entry
5577              CDS       T01001                                 
Symbol
PRKAR2B, PRKAR2, RII-BETA
Name
(RefSeq) protein kinase cAMP-dependent type II regulatory subunit beta
  KO
K04739  cAMP-dependent protein kinase regulator
Organism
hsa  Homo sapiens (human)
Pathway
hsa04910  Insulin signaling pathway
Network
nt06310  CRH-ACTH-cortisol signaling
  Element
N01542  PKA holoenzyme
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    5577 (PRKAR2B)
SSDB
Motif
Pfam: cNMP_binding RIIa DUF7386
Other DBs
NCBI-GeneID: 5577
NCBI-ProteinID: NP_002727
OMIM: 176912
HGNC: 9392
Ensembl: ENSG00000005249
UniProt: P31323 B3KY43
LinkDB
Position
7:107044705..107161811
AA seq 418 aa
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD
LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY
NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH
VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS
PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG
EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP
RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
NT seq 1257 nt   +upstreamnt  +downstreamnt
atgagcatcgagatcccggcgggactgacggagctgctgcagggcttcacggtggaggtg
ctgaggcaccagcccgcggacctgctggagttcgcgctgcagcacttcacccgcctgcag
caggagaacgagcgcaaaggcaccgcgcgcttcggccatgagggcaggacctggggggac
ctgggcgccgctgccgggggcggcacccccagcaagggggtcaacttcgccgaggagccc
atgcagtccgactccgaggacggggaggaggaggaggcggcgcccgcggacgcaggggcg
ttcaatgctccagtaataaaccgattcacaaggcgtgcctcagtatgtgcagaagcttat
aatcctgatgaagaagaagatgatgcagagtccaggattatacatccaaaaactgatgat
caaagaaataggttgcaagaggcttgcaaagacatcctgctgtttaagaatctggatccg
gagcagatgtctcaagtattagatgccatgtttgaaaaattggtcaaagatggggagcat
gtaattgatcaaggtgacgatggtgacaacttttatgtaattgatagaggcacatttgat
atttatgtgaaatgtgatggtgttggaagatgtgttggtaactatgataatcgtgggagt
ttcggcgaactggccttaatgtacaatacacccagagcagctacaatcactgctacctct
cctggtgctctgtggggtttggacagggtaaccttcaggagaataattgtgaaaaacaat
gccaaaaagagaaaaatgtatgaaagctttattgagtcactgccattccttaaatctttg
gagttttctgaacgcctgaaagtagtagatgtgataggcaccaaagtatacaacgatgga
gaacaaatcattgctcagggagattcggctgattcttttttcattgtagaatctggagaa
gtgaaaattactatgaaaagaaagggtaaatcagaagtggaagagaatggtgcagtagaa
atcgctcgatgctcgcggggacagtactttggagagcttgccctggtaactaacaaacct
cgagcagcttctgcccacgccattgggactgtcaaatgtttagcaatggatgtgcaagca
tttgaaaggcttctgggaccttgcatggaaattatgaaaaggaacatcgctacctatgaa
gaacagttagttgccctgtttggaacgaacatggatattgttgaacccactgcatga

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