KEGG   Homo sapiens (human): 5691
Entry
5691              CDS       T01001                                 
Symbol
PSMB3, HC10-II
Name
(RefSeq) proteasome 20S subunit beta 3
  KO
K02735  20S proteasome subunit beta 3 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5691 (PSMB3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5691 (PSMB3)
   05012 Parkinson disease
    5691 (PSMB3)
   05014 Amyotrophic lateral sclerosis
    5691 (PSMB3)
   05016 Huntington disease
    5691 (PSMB3)
   05017 Spinocerebellar ataxia
    5691 (PSMB3)
   05020 Prion disease
    5691 (PSMB3)
   05022 Pathways of neurodegeneration - multiple diseases
    5691 (PSMB3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5691 (PSMB3)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5691 (PSMB3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5691 (PSMB3)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5691 (PSMB3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5691 (PSMB3)
SSDB
Motif
Pfam: Proteasome
Other DBs
NCBI-GeneID: 5691
NCBI-ProteinID: NP_002786
OMIM: 602176
HGNC: 9540
Ensembl: ENSG00000277791
UniProt: P49720 A0A384NL22
Structure
LinkDB
Position
17:38752741..38764225
AA seq 205 aa
MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
SGMGVIVHIIEKDKITTRTLKARMD
NT seq 618 nt   +upstreamnt  +downstreamnt
atgtctattatgtcctataacggaggggccgtcatggccatgaaggggaagaactgtgtg
gccatcgctgcagacaggcgcttcgggatccaggcccagatggtgaccacggacttccag
aagatctttcccatgggtgaccggctgtacatcggtctggccgggctcgccactgacgtc
cagacagttgcccagcgcctcaagttccggctgaacctgtatgagttgaaggaaggtcgg
cagatcaaaccttataccctcatgagcatggtggccaacctcttgtatgagaaacggttt
ggcccttactacactgagccagtcattgccgggttggacccgaagacctttaagcccttc
atttgctctctagacctcatcggctgccccatggtgactgatgactttgtggtcagtggc
acctgcgccgaacaaatgtacggaatgtgtgagtccctctgggagcccaacatggatccg
gatcacctgtttgaaaccatctcccaagccatgctgaatgctgtggaccgggatgcagtg
tcaggcatgggagtcattgtccacatcatcgagaaggacaaaatcaccaccaggacactg
aaggcccgaatggactaa

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