KEGG   NETWORK: N00098
Entry
N00098                      Network                                
Name
Intrinsic apoptotic pathway
Definition
(PMAIP1,BBC3,BAD,BCL2L11) -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
(5366,27113,572,10018) -| (596,598) -| (581,578) -> 54205 == 317 -> 842 -> (836,840)
Class
nt06524 Apoptosis
nt06260 Colorectal cancer
nt06267 Small cell lung cancer
nt06231 Apoptosis (cancer)
nt06463 Parkinson disease
nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06170 Influenza A virus (IAV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06165 Epstein-Barr virus (EBV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04210  Apoptosis
Gene
5366  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113  BBC3; BCL2 binding component 3
572  BAD; BCL2 associated agonist of cell death
10018  BCL2L11; BCL2 like 11
596  BCL2; BCL2, apoptosis regulator
598  BCL2L1; BCL2 like 1
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Reference
PMID:21697901
  Authors
Vucic D, Dixit VM, Wertz IE
  Title
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
  Journal
Nat Rev Mol Cell Biol 12:439-52 (2011)
DOI:10.1038/nrm3143
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:20683470
  Authors
Tait SW, Green DR
  Title
Mitochondria and cell death: outer membrane permeabilization and beyond.
  Journal
Nat Rev Mol Cell Biol 11:621-32 (2010)
DOI:10.1038/nrm2952
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