KEGG   Homo sapiens (human): 6015
Entry
6015              CDS       T01001                                 
Symbol
RING1, RING1A, RNF1
Name
(RefSeq) ring finger protein 1
  KO
K10695  E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01585  Deubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
N01620  Blocking ubiquitination of H2AK119 by CK2
N01701  Transcriptional activation by acetylation of H3K27
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    6015 (RING1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6015 (RING1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    6015 (RING1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     6015 (RING1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    6015 (RING1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Canonical PRC1 (PRC1.2/1.4)
     6015 (RING1)
    Noncanonical PRC1 (PRC1.1)
     6015 (RING1)
    Noncanonical PRC1 (PRC1.3/1.5)
     6015 (RING1)
    Noncanonical PRC1 (PRC1.6)
     6015 (RING1)
SSDB
Motif
Pfam: RAWUL zf-C3HC4_2 zf-C3HC4 zf-RING_2 zf-C3HC4_3 zf-RING_UBOX zf-Nse zf-C3HC4_4 zf-RING_6 zf-RING_4 zf-RING_5 RING_XB3-XBAT31 zf-rbx1 zf-UDP TRAF3_RING zf-C3HC4_5 Sina_RING zf-ANAPC11
Other DBs
NCBI-GeneID: 6015
NCBI-ProteinID: NP_002922
OMIM: 602045
HGNC: 10018
Ensembl: ENSG00000204227
UniProt: Q06587 A0A1U9X8F2
LinkDB
Position
6:33208500..33212716
AA seq 406 aa
MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMT
TKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAH
QDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGE
GDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLG
GGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLA
LRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQ
YTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
NT seq 1221 nt   +upstreamnt  +downstreamnt
atgacgacgccggcgaatgcccagaatgccagcaaaacgtgggaactgagtctgtatgag
ctgcaccggaccccgcaggaagccataatggatggcacagagattgctgtttcccctcgg
tcactgcattcagaactcatgtgccctatctgcctggacatgctgaagaatacgatgacc
accaaggagtgcctccacagattctgctctgactgcattgtcacagccctacggagcggg
aacaaggagtgtcctacctgccgaaagaagctggtgtccaagcgatccctacggccagac
cccaactttgatgccctgatctctaagatctatcctagccgggaggaatacgaggcccat
caagaccgagtgcttatccgcctgagccgcctgcacaaccagcaggcattgagctccagc
attgaggaggggctacgcatgcaggccatgcacagggcccagcgtgtgaggcggccgata
ccagggtcagatcagaccacaacgatgagtgggggggaaggagagcccggggagggagaa
ggggatggagaagatgtgagctcagactccgcccctgactctgccccaggccctgctccc
aagcgaccccgtggagggggcgcaggggggagcagtgtagggacagggggaggcggcact
ggtggggtgggtgggggtgccggttcggaagactctggtgaccggggagggactctggga
gggggaacgctgggccccccaagccctcctggggcccccagccccccagagccaggtgga
gaaattgagctcgtgttccggccccaccccctgctcgtggagaagggagaatactgccag
acgaggtatgtgaagacaactgggaatgccacagtggaccacctctccaagtacttggcc
ctgcgcattgccctcgagcggaggcaacagcaggaagcaggggagccaggagggcctgga
gggggcgcctctgacaccggaggacctgatgggtgtggcggggagggtgggggtgccgga
ggaggtgacggtcctgaggagcctgctttgcccagcctggagggcgtcagtgaaaagcag
tacaccatctacatcgcacctggaggcggggcgttcacgacgttgaatggctcgctgacc
ctggagctggtgaatgagaaattctggaaggtgtcccggccactggagctgtgctatgct
cccaccaaggatccaaagtga

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