KEGG T01001: 6500

Homo sapiens (human): 6500

Entry

6500              CDS       T01001

Symbol

SKP1, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A

Name

(RefSeq) S-phase kinase associated protein 1

K03094

S-phase kinase-associated protein 1

Organism

hsa Homo sapiens (human)

Pathway

hsa03083

Polycomb repressive complex

hsa04110

Cell cycle

hsa04114

Oocyte meiosis

hsa04120

Ubiquitin mediated proteolysis

hsa04141

Protein processing in endoplasmic reticulum

hsa04310

Wnt signaling pathway

hsa04350

TGF-beta signaling pathway

hsa04710

Circadian rhythm

hsa05131

Shigellosis

hsa05132

Salmonella infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

Network

nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06181  Salmonella
nt06182  Shigella
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06516  TNF signaling
nt06523  Epigenetic regulation by Polycomb complexes

Element

N00091

p27-Cell cycle G1/S

N00092

Amplified MYC to p27-cell cycle G1/S

N00942

Shigella OspG to TNF-NFKB signaling pathway

N01117

Salmonella GogB to TNF-NFKB signaling pathway

N01586

Activation of PRC2.2 by ubiquitination of H2AK119

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    6500 (SKP1)
   04120 Ubiquitin mediated proteolysis
    6500 (SKP1)
  09126 Chromosome
   03083 Polycomb repressive complex
    6500 (SKP1)
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    6500 (SKP1)
   04350 TGF-beta signaling pathway
    6500 (SKP1)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    6500 (SKP1)
   04114 Oocyte meiosis
    6500 (SKP1)
09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    6500 (SKP1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6500 (SKP1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    6500 (SKP1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    6500 (SKP1)
   05131 Shigellosis
    6500 (SKP1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    6500 (SKP1)
   04121 Ubiquitin system [BR:hsa04121]
    6500 (SKP1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    6500 (SKP1)
Membrane trafficking [BR:hsa04131]
Endosome - Lysosome transport
  Acidification regulators
   RAVE complex
    6500 (SKP1)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   SCF complex
    Adaptor protein
     6500 (SKP1)
   Cul7 complex
     6500 (SKP1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.1)
     6500 (SKP1)
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CBF3 complex
     6500 (SKP1)

SSDB

Motif

Pfam:

Skp1 Skp1_POZ

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

5:complement(134148935..134176950)

AA seq 163 aa
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQ
WCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTC
KTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK

NT seq 492 nt +upstreamnt +downstreamnt
atgccttcaattaagttgcagagttctgatggagagatatttgaagttgatgtggaaatt
gccaaacaatctgtgactattaagaccatgttggaagatttgggaatggatgatgaagga
gatgatgacccagttcctctaccaaatgtgaatgcagcaatattaaaaaaggtcattcag
tggtgcacccaccacaaggatgaccctcctcctcctgaagatgatgagaacaaagaaaag
cgaacagatgatatccctgtttgggaccaagaattcctgaaagttgaccaaggaacactt
tttgaactcattctggctgcaaactacttagacatcaaaggtttgcttgatgttacatgc
aagactgttgccaatatgatcaaggggaaaactcctgaggagattcgcaagaccttcaat
atcaaaaatgactttactgaagaggaggaagcccaggtacgcaaagagaaccagtggtgt
gaagagaagtga

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