Homo sapiens (human): 6790
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Entry
6790 CDS
T01001
Symbol
AURKA, AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7
Name
(RefSeq) aurora kinase A isoform 1
KO
K11481
aurora kinase A [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04114
Oocyte meiosis
hsa04914
Progesterone-mediated oocyte maturation
Network
nt06515
Regulation of kinetochore-microtubule interactions
Element
N01531
CENPE interaction with NDC80 complex
N01547
Kinetochore fiber organization
N01561
Microtubule depolymerization
N01563
Inhibition of Kif2A
Disease
H00020
Colorectal cancer
Drug target
Alisertib (
DG01855
):
D10085
D10086
Ilorasertib:
D10423
Tinengotinib:
D12545
Tozasertib (
DG01365
):
D08279
D08344
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04114 Oocyte meiosis
6790 (AURKA)
09150 Organismal Systems
09152 Endocrine system
04914 Progesterone-mediated oocyte maturation
6790 (AURKA)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6790 (AURKA)
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
6790 (AURKA)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
6790 (AURKA)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
6790 (AURKA)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
AUR family [OT]
6790 (AURKA)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
6790 (AURKA)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
6790 (AURKA)
Spindle formation proteins
6790 (AURKA)
Sister chromatid separation proteins
Aurora kinases
6790 (AURKA)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
ABC1
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
6790
NCBI-ProteinID:
NP_001310232
OMIM:
603072
HGNC:
11393
UniProt:
O14965
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:complement(56369390..56392215)
Genome browser
AA seq
403 aa
AA seq
DB search
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
NT seq
1212 nt
NT seq
+upstream
nt +downstream
nt
atggaccgatctaaagaaaactgcatttcaggacctgttaaggctacagctccagttgga
ggtccaaaacgtgttctcgtgactcagcaatttccttgtcagaatccattacctgtaaat
agtggccaggctcagcgggtcttgtgtccttcaaattcttcccagcgcattcctttgcaa
gcacaaaagcttgtctccagtcacaagccggttcagaatcagaagcagaagcaattgcag
gcaaccagtgtacctcatcctgtctccaggccactgaataacacccaaaagagcaagcag
cccctgccatcggcacctgaaaataatcctgaggaggaactggcatcaaaacagaaaaat
gaagaatcaaaaaagaggcagtgggctttggaagactttgaaattggtcgccctctgggt
aaaggaaagtttggtaatgtttatttggcaagagaaaagcaaagcaagtttattctggct
cttaaagtgttatttaaagctcagctggagaaagccggagtggagcatcagctcagaaga
gaagtagaaatacagtcccaccttcggcatcctaatattcttagactgtatggttatttc
catgatgctaccagagtctacctaattctggaatatgcaccacttggaacagtttataga
gaacttcagaaactttcaaagtttgatgagcagagaactgctacttatataacagaattg
gcaaatgccctgtcttactgtcattcgaagagagttattcatagagacattaagccagag
aacttacttcttggatcagctggagagcttaaaattgcagattttgggtggtcagtacat
gctccatcttccaggaggaccactctctgtggcaccctggactacctgccccctgaaatg
attgaaggtcggatgcatgatgagaaggtggatctctggagccttggagttctttgctat
gaatttttagttgggaagcctccttttgaggcaaacacataccaagagacctacaaaaga
atatcacgggttgaattcacattccctgactttgtaacagagggagccagggacctcatt
tcaagactgttgaagcataatcccagccagaggccaatgctcagagaagtacttgaacac
ccctggatcacagcaaattcatcaaaaccatcaaattgccaaaacaaagaatcagctagc
aaacagtcttag
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