KEGG   NETWORK: N01561
Entry
N01561                      Network                                
Name
Microtubule depolymerization
Definition
(AURKA,AURKB) -| (MCAK+KIF18B) == EB1,EB3 == microtubule
  Expanded
(6790,9212) -| (11004+146909) == 22919,22924 == (7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688)
Class
nt06515 Regulation of kinetochore-microtubule interactions
Type
Reference
Gene
6790  AURKA; aurora kinase A
9212  AURKB; aurora kinase B
11004  KIF2C; kinesin family member 2C
146909  KIF18B; kinesin family member 18B
22919  MAPRE1; microtubule associated protein RP/EB family member 1
22924  MAPRE3; microtubule associated protein RP/EB family member 3
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Reference
PMID:35502670
  Authors
McHugh T, Welburn JPI
  Title
Potent microtubule-depolymerizing activity of a mitotic Kif18b-MCAK-EB network.
  Journal
J Cell Sci 136:jcs260144 (2023)
DOI:10.1242/jcs.260144
Reference
PMID:21737685
  Authors
Stout JR, Yount AL, Powers JA, Leblanc C, Ems-McClung SC, Walczak CE
  Title
Kif18B interacts with EB1 and controls astral microtubule length during mitosis.
  Journal
Mol Biol Cell 22:3070-80 (2011)
DOI:10.1091/mbc.E11-04-0363
Reference
PMID:21820309
  Authors
Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH
  Title
A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.
  Journal
Curr Biol 21:1356-65 (2011)
DOI:10.1016/j.cub.2011.07.017
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