KEGG T01001: 6921

Homo sapiens (human): 6921

Entry

6921              CDS       T01001

Symbol

ELOC, SIII, TCEB1

Name

(RefSeq) elongin C

K03872

elongin-C

Organism

hsa Homo sapiens (human)

Pathway

hsa04066

HIF-1 signaling pathway

hsa04120

Ubiquitin mediated proteolysis

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

hsa05211

Renal cell carcinoma

Network

nt06225  HIF-1 signaling (cancer)
nt06264  Renal cell carcinoma
nt06509  DNA replication
nt06523  Epigenetic regulation by Polycomb complexes
nt06542  HIF signaling

Element

N00080

Loss of VHL to HIF-1 signaling pathway

N00081

Mutation-inactivated VHL to HIF-1 signaling pathway

N01473

DNA replication termination

N01577

Gene silencing by methylation of H3K27 and ubiquitination of H2AK119

N01872

Proteasomal degradation of HIF by VHL complex

N01873

VHL mutation to HIF-2 signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    6921 (ELOC)
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    6921 (ELOC)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6921 (ELOC)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    6921 (ELOC)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    6921 (ELOC)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6921 (ELOC)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    6921 (ELOC)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul2 complex
    Adoptor protein
     6921 (ELOC)
   Cul5 complex
     6921 (ELOC)
DNA repair and recombination proteins [BR:hsa03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    Other NER factors
     6921 (ELOC)

SSDB

Motif

Pfam:

Skp1_POZ

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

8:complement(73945119..73972287)

AA seq 112 aa
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEV
NFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

NT seq 339 nt +upstreamnt +downstreamnt
atggatggagaggagaaaacctatggtggctgtgaaggacctgatgccatgtatgtcaaa
ttgatatcatctgatggccatgaatttattgtaaaaagagaacatgcattaacatcaggc
acgataaaagccatgttgagtggcccaggtcagtttgctgagaacgaaaccaatgaggtc
aattttagagagataccttcacatgtgctatcgaaagtatgcatgtattttacgtacaag
gttcgctacactaacagctccaccgagattcctgaattcccaattgcacctgaaattgca
ctggaactgctgatggctgcgaacttcttagattgttaa

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